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scrB-1

Victor ID 4780
Gene Name scrB-1
Sequence Strain (Species/Organism) Enterococcus faecalis V583
NCBI Gene ID 1200501
NCBI Protein GI 29376163
Locus Tag EF1603
Genbank Accession AE016830
Protein Accession NP_815317
Taxonomy ID 226185
Gene Starting Position 1557237
Gene Ending Position 1558697
Gene Strand (Orientation) +
Protein Name sucrose-6-phosphate dehydrogenase
Protein pI 5.04
Protein Weight 52789.17
Protein Length 486
Protein Note similar to PIR: S68598; identified by sequence similarity; putative
DNA Sequence 
>gi|29374661:1557237-1558697 Enterococcus faecalis V583 chromosome, complete genome
CATGAACCAATGGACGGATGAATTACGTTATGCGCCTTATTCTTCTTGGACATCTGCTCACCTCGAAAAT
CTAACTTCTATTATCGCGCAATCTAGTTGGCGTTTTAAGTATCATATTCAACCACAGACAGGACTACTAA
ATGATCCCAACGGTTTTTCGTATTTCAATAACCAGTGGCATTTATTTTATCAAGCGTTTCCTTTCGGGAG
TGTTCACGGACTAAAAAGTTGGGCCCACTTAACTTCCTCCGACTTAATTCACTGGGATTATGAAGGAATT
GCCCTTTATCCCGACTCTGAATATGATTCTCATGGCGTCTATTCAGGCTCAGCTTTAACAATAGATAACC
AACTATGTTTATTTTATACAGGAAATGTTCGTGATCAAACTTGGCAACGATTTGCATATCAAAATATTGC
ATGGCTGAATTCTTTAGGTGCGATCACAAAGGAATCAACACCATTCCTACCTATTGACCCCAATTATTCT
TCCCATTTTCGTGATCCGATGGTATTTCCTTATCAAGAAGGACTTGTTTTATTAATTGGTGCTAGTGATT
TAAATGGACAAGGAAAAATTGTGGTCTATTTTTCTAAAGATCGAAATGTACACAATTTTCATCAACTTGG
CGAATTGACGTTCACCAACCAAGAATTAGGCTACATGGTTGAATGCCCCAATTTGGTATTTATTGATGGC
CAGCCTGTCTTATTATTTTGCCCACAAGGTCTATCTCCATCTGTAAAAAGTTATCAGAATATCTATCCGA
ATATGTACACATTGGCCGAAACGTTTGATTTGGAGAATCTTTCTTTAGTTCAGGCTGGGCCTTTTGAAAA
TTTAGATGAAGGATTTGATGTCTACGCCACTCAAGCCTTTAATGCGCCAGATGGTCGTGCACTTGCGGTC
AGTTGGATTGGGTTGCCAGAAATCACTTACCCAAGTGATGTGGAGGGTTGGGCAAATGGCTTAAGTCTGG
TTAAAGAACTCACAATTCACAACGGGAAACTATTTCAATATCCAGTTTCTGAAACAGAAATGCTTCGTCA
ATCCGCTACTACTTTATCAAATGGCTGCCATTTCTTATCTACTGCTTCTTTTGAATTAGAAGTGGATATT
CCCAAAAATGAGATTGCTTTTATTCGGCTTTTAGCGAACGAAACGGGTTCAAAAGGACTTTTAATTACAA
TTGATACGATTCATGGTAAAATAACCCTTGATCGAACATTTGCTGGCCAATCTTTTGCTGAAAAGTATGG
CACAATTCGTGAAACTAAAATTAGGAAAAATAAGTCAGTTCAGTTAACTATTTTTGTTGATTGCTCTGTT
GCAGAAATCTATGTAAATAAAGGTGAAAAAACGATGACTGGTCGCTTCTTTCCAGATAAAGCGCAACAGT
ATCTTCATCTATCCAAGACGGCAAAAGCTTGTTTTTATGAGCTGGAAAATACGAATAATTA
Protein Sequence 
>gi|29376163|ref|NP_815317.1| sucrose-6-phosphate dehydrogenase [Enterococcus faecalis V583]
MNQWTDELRYAPYSSWTSAHLENLTSIIAQSSWRFKYHIQPQTGLLNDPNGFSYFNNQWHLFYQAFPFGS
VHGLKSWAHLTSSDLIHWDYEGIALYPDSEYDSHGVYSGSALTIDNQLCLFYTGNVRDQTWQRFAYQNIA
WLNSLGAITKESTPFLPIDPNYSSHFRDPMVFPYQEGLVLLIGASDLNGQGKIVVYFSKDRNVHNFHQLG
ELTFTNQELGYMVECPNLVFIDGQPVLLFCPQGLSPSVKSYQNIYPNMYTLAETFDLENLSLVQAGPFEN
LDEGFDVYATQAFNAPDGRALAVSWIGLPEITYPSDVEGWANGLSLVKELTIHNGKLFQYPVSETEMLRQ
SATTLSNGCHFLSTASFELEVDIPKNEIAFIRLLANETGSKGLLITIDTIHGKITLDRTFAGQSFAEKYG
TIRETKIRKNKSVQLTIFVDCSVAEIYVNKGEKTMTGRFFPDKAQQYLHLSKTAKACFYELENTNN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: scrB mutant is avirulent in C. elegans and attenuated in mice (Garsin et al., 2001).
MUTATION: scrB-1 mutant is attenuated in killing C. elegans and is attenuated in mice (Maadani et al., 2007).
References
Garsin et al., 2001: Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, Calderwood SB, Ausubel FM. A simple model host for identifying Gram-positive virulence factors. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(19); 10892-10897. [PubMed: 11535834].
Maadani et al., 2007: Maadani A, Fox KA, Mylonakis E, Garsin DA. Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host. Infection and immunity. 2007; 75(5); 2634-2637. [PubMed: 17307944].