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thyA

Victor ID 4805
Gene Name thyA
Sequence Strain (Species/Organism) Enterococcus faecalis V583
NCBI Gene ID 1200476
NCBI Protein GI 29376139
Locus Tag EF1576
Genbank Accession AE016830
Protein Accession NP_815293
Taxonomy ID 226185
Gene Starting Position 1529047
Gene Ending Position 1529994
Gene Strand (Orientation) +
Protein Name thymidylate synthase
Protein pI 4.85
Protein Weight 34656.66
Protein Length 315
Protein Note ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
DNA Sequence 
>gi|29374661:1529047-1529994 Enterococcus faecalis V583 chromosome, complete genome
GATGGAAGAAGCATACTTAGCGCTAGGAAAAAAGATTTTAGAAGAAGGTCATTTTAAAGAAGACCGTACA
GGAACTGGGACGTATAGTTTATTTGGCTATCAAATGCGTTTTGATTTGGCCAAAGGATTTCCCTTACTAA
CAACCAAACGAGTACCGTTTGGCTTGATTAAAAGTGAGTTATTGTGGTTTTTAAAAGGCGACACGAATAT
TCGCTATTTGTTAGAGCGAAATAATCATATTTGGGATGAATGGGCGTTCGAACGTTACGTAAAAAGCGCA
GATTATCAAGGACCAGACATGACGGATTTTGGGCATCGTGTCTTACAAGATCCAGCGTTTGCAGAACAAT
ACAAAGAAGAACATCAAAAATTCTGTGATGCCATTTTAAATGATGCAGAGTTTGCAGAAAAATATGGTGA
ATTAGGGAATATTTATGGTGCACAATGGCGTCACTGGGAAACCAAAGATGGTAGCTTTATCGATCAATTA
GCTAATGTGATTGAAATGATTAAAACCAATCCTGATTCTCGCCGTTTAATTGTTTCCGCTTGGAATCCAG
AAGATGTGCCTTCAATGGCGTTGCCGCCTTGTCACACTATGTTTCAATTTTATGTAAATGAAGGAAAATT
AAGCTGTCAACTTTATCAGCGCAGTGCCGATGTTTTTTTAGGTGTTCCTTTTAACATTGCAAGCTATGCT
TTATTGACACATCTGATTGCGCATGAAACAGGTTTAGAAGTGGGGGAGTTTGTACACACGCTAGGAGATG
CCCACTTATATCAAAATCATGTGGAACAAATGCAAGAACAATTATCACGAGAAGTTCGTTCTTTCCCAAC
GCTCGTTTTGAATCCAGACAAGGCTTCTGTTTTTGATTTTGATATGGAAGATATTAAAGTAGAAGGCTAT
GACCCACATCCAACGATTAAAGCGCCGATTGCCGTATA
Protein Sequence 
>gi|29376139|ref|NP_815293.1| thymidylate synthase [Enterococcus faecalis V583]
MEEAYLALGKKILEEGHFKEDRTGTGTYSLFGYQMRFDLAKGFPLLTTKRVPFGLIKSELLWFLKGDTNI
RYLLERNNHIWDEWAFERYVKSADYQGPDMTDFGHRVLQDPAFAEQYKEEHQKFCDAILNDAEFAEKYGE
LGNIYGAQWRHWETKDGSFIDQLANVIEMIKTNPDSRRLIVSAWNPEDVPSMALPPCHTMFQFYVNEGKL
SCQLYQRSADVFLGVPFNIASYALLTHLIAHETGLEVGEFVHTLGDAHLYQNHVEQMQEQLSREVRSFPT
LVLNPDKASVFDFDMEDIKVEGYDPHPTIKAPIAV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: thyA mutant is attenuated in killing C. elegans (Maadani et al., 2007).
References
Maadani et al., 2007: Maadani A, Fox KA, Mylonakis E, Garsin DA. Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host. Infection and immunity. 2007; 75(5); 2634-2637. [PubMed: 17307944].