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purL

Victor ID 4781
Gene Name purL
Sequence Strain (Species/Organism) Enterococcus faecalis V583
NCBI Gene ID 1200671
NCBI Protein GI 29376329
Locus Tag EF1782
Genbank Accession AE016830
Protein Accession NP_815483
Taxonomy ID 226185
Gene Starting Position 1726260
Gene Ending Position 1728479
Gene Strand (Orientation) -
Protein Name phosphoribosylformylglycinamidine synthase II
Protein pI 4.51
Protein Weight 75176.22
Protein Length 739
Protein Note catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
DNA Sequence 
>gi|29374661:1726260-1728479 Enterococcus faecalis V583 chromosome, complete genome
TTTAAGCTTTTTGCTTCATAAGACATGGAATCGCATCCTCCCATAAGGCTTTGGCTTCTTTTGTTGAGCA
ATTGATCACATCATCTAACGCATGAATGACCAAACCAGTTTCAGTCACTTTCCCAATATGTTGAGCTTTT
CTTCCGATAAGTGTTTCAAATGCTTCTTGATGCTGGGGACTAACTGAAAGAATAAAACGGGATTGCGTCT
CCGCAAATAGATATTCTTTTTTTAATGGCAGTGTCACCTGTAACCCCAGTTCGTTAGCAAAAGCCGACTC
GGCTAAAGCAACGGCAACGCCACCTTCAGCGCAATCATGCGCGCTAGCAACTAGGCCTACTTGAATTGCT
TTTAAAACTAATTCTTGGTTTGCTTTTTCCTCTTTTAAATCAAATGAGCGTAATTGCCCTTCAATTCGAC
CCAGTTGTATTTTTTGAATTTCTGAGCCGTTAAAATCTGCGTGGGTTTCACCGATGAGATAAATTAAGTC
ATCAACTTGTTTAAACGCTTGTGTGGTAATTTGTGAAACATCTTCAATCACTCCCACCATGCCAATCATT
GGCGTTGGATAAATGGCTTGACCATCTGTTTCATTGTAAAGAGAGACGTTCCCTGAAATCACGGGTGTTC
CTAGCTGACGGCAGGCGGCGGCGATTCCATCCGCCGACGTCCATAATTCCCAAAAACTTTCTGGTTTATC
TGGGGAACCATAATTCAAGCAATCAGTGATAGCCAAAGGTTGTGCTCCACTCGCTACAATATTACGGGCT
GCTTCTGCAACCGCAATTTGCCCACCAATTTCAGGATTTAAATACAAATAACGGCTATTACAATCTGTCG
TCATCGCTAAGGCTTTATTGGTGCCCCGCACTCTTAAAACAGCTGCATCACTTCCTGGTTGCACCACTGT
ATTCGTTTGTACTTGACTATCATAGGTTTCGTAAACTGATTTTTTCGATGCAATCGTTGGCTGTTGCAAT
AGGCGTTTTAATAATTCCGTACTATTCGTAATTTCTGGAATGAAGGGCGCTAATTTTTTAAAAGCACGCA
TCCGCTCTGGTTCTTGATAGGCTTTCTGGTAGACAGGGGCTTCTTCTGCCAAAGCATCTACTGGTACATC
TGCGACTATTTTGCCACCGTGAAAGACACGATACTGTCCATCATCTGTTACGGAGCCAATCGCTACCGCT
TCTAAGTCATACGTTTGAAACAATTCACAAACTTGCTGTTCTGCTCCTTTTTCCACACAGATTAACATCC
GTTCTTGGGACTCAGACAAGAGCATTTCATAGGGGCTCATCTGCGTCTCTCTCTGCGGAACTTTATCTAG
CTCTAGAATCAAGCCTGAACCTGCTTTTGATGCCATTTCAGCACTTGAAGAAACCAAGCCAGCCGCCCCC
ATATCTTGGATGCCGATTAAAATATCTTGATGATTTTTGATTAAATCAAGACAAGCTTCCAATAATAATT
TTTCCATAAACGGATCACCTACTTGTACCGCAGATCGTTGCTGTTCTTCACCTTCACTAAATTCTTCTGA
AGCAAAGGTCGCACCATGAATTCCATCTCGTCCTGTTTTCGCACCTACGTAAAGAATGCTATTTCCGACG
CCTTTTGCTTGGCCTTTTTGAATCTCATCATGACGAATCAATCCCACACACATAGCATTAACAAGTGGGT
TTCCTTGATAACATGGCTCAAAAGCAATTTCGCCGCCAACGGTTGGAATACCAATACAATTTCCATAACC
GCTAATCCCCGCCACAACTTCTTGAAACAAATAACGTGTTCGTGCATCCGTCAGTTCGCCAAATCTTAGC
GAATCCAGTAAAGCAATCGGCCGCGCCCCCATACTGAAAATATCGCGAATAATTCCACCAACGCCTGTAG
CTGCTCCTTCGTAAGGTTCTACTGCAGAAGGATGATTATGGCTCTCTGCTTTAAAAACAACAGCTAATCC
GTCACCAATATCGACAATCCCAGCTCCTTCACCAGGGCCTTGAAGCACTTGTGGCCCTTCCGTCGGAAAC
TTTTTTAAAACGGGCTTGGAATTTTTGTAAGAGCAATGTTCACTCCACATCACGGAGAATAAGCCAGTTT
CTGTATAATTAGGTTCTCTTTGCAAAATGGTCTCAATCTGATGATATTCTTCATCTGTTAGTCCCCATTC
TGCATACAACCGTGTTTCCTTGATTTCTTTTGGTGTTGGTTCATTCATCA
Protein Sequence 
>gi|29376329|ref|NP_815483.1| phosphoribosylformylglycinamidine synthase II [Enterococcus faecalis V583]
MMNEPTPKEIKETRLYAEWGLTDEEYHQIETILQREPNYTETGLFSVMWSEHCSYKNSKPVLKKFPTEGP
QVLQGPGEGAGIVDIGDGLAVVFKAESHNHPSAVEPYEGAATGVGGIIRDIFSMGARPIALLDSLRFGEL
TDARTRYLFQEVVAGISGYGNCIGIPTVGGEIAFEPCYQGNPLVNAMCVGLIRHDEIQKGQAKGVGNSIL
YVGAKTGRDGIHGATFASEEFSEGEEQQRSAVQVGDPFMEKLLLEACLDLIKNHQDILIGIQDMGAAGLV
SSSAEMASKAGSGLILELDKVPQRETQMSPYEMLLSESQERMLICVEKGAEQQVCELFQTYDLEAVAIGS
VTDDGQYRVFHGGKIVADVPVDALAEEAPVYQKAYQEPERMRAFKKLAPFIPEITNSTELLKRLLQQPTI
ASKKSVYETYDSQVQTNTVVQPGSDAAVLRVRGTNKALAMTTDCNSRYLYLNPEIGGQIAVAEAARNIVA
SGAQPLAITDCLNYGSPDKPESFWELWTSADGIAAACRQLGTPVISGNVSLYNETDGQAIYPTPMIGMVG
VIEDVSQITTQAFKQVDDLIYLIGETHADFNGSEIQKIQLGRIEGQLRSFDLKEEKANQELVLKAIQVGL
VASAHDCAEGGVAVALAESAFANELGLQVTLPLKKEYLFAETQSRFILSVSPQHQEAFETLIGRKAQHIG
KVTETGLVIHALDDVINCSTKEAKALWEDAIPCLMKQKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in mice (Singh et al., 1998).
References
Singh et al., 1998: Singh KV, Qin X, Weinstock GM, Murray BE. Generation and testing of mutants of Enterococcus faecalis in a mouse peritonitis model. The Journal of infectious diseases. 1998; 178(5); 1416-1420. [PubMed: 9780263].