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prgB

Victor ID 4789
Gene Name prgB
Sequence Strain (Species/Organism) Enterococcus faecalis
NCBI Gene ID 3267210
NCBI Protein GI 58616135
Locus Tag pCF10_16
Genbank Accession AY855841
Protein Accession YP_195774
Taxonomy ID 1351
Plasmid No pCF10
Gene Starting Position 12882
Gene Ending Position 16799
Gene Strand (Orientation) +
Protein Name PrgB
Protein pI 6.09
Protein Weight 130097.25
Protein Length 1305
DNA Sequence 
>gi|113706804:12882-16799 Enterococcus faecalis plasmid pCF10, complete sequence
CATGAATCAACAGACTGAAGTAAAAAAACGTTTTAAAATGTATAAGGCAAAGAAGCATTGGATCGTAGCT
CCTATTCTTTTTCTAGGCGTGTTAGGAGTTGTAGGATTAGCTACTGATAATGTACAAGCAGCGGAATTAG
ATACGCAACCAGGATCAACGACAGTGCACCCCGATAACCCCGATCCGCAGTTAGGTAGTGCAACGCCTAA
TACGGCAGTATCTGAAGAATCTGCAGTACAAAAAGACACTACTTCTCAACCGACCAAAGCAGAAGAAGTA
GCGTCTGAAAAAAATGGAGCTGAACAGAGTTCAGCTACCCCAAATGATACCACAAACGTCCAACAACCAA
CAGTAGGAGCTGAAAAATCAGCACAAGAACAACCAGTAGTAAGCCCTGAAACAACCAATGAACCTCTAGG
GCAGCCAACAGAAGTTGCACCAGCTGAAAATGAAGCGAATAAATCAACGTCCATTCTTAAAGAATTTGAA
ACACCAGACGTTGATAAAGCAGTTGATGAAGCAAAAAAAGATCCAAACATTACCGTTGTTGAAAAACCAG
CAGAAGACTTAGGCAACGTTTCTTCTAAAGATTTAGCTGCAAAAGAAAAAGAAGTAGACCAACTACAAAA
AGAACAAGCGAAAAAGATTGCCCAACAAGCAGCTGAATTAAAAGCCAAAAATGAAAAAATTGCCAAAGAA
AATGCAGAAATTGCGGCAAAAAACAAAGCGGAAAAAGAGCCGTACGAGAAAGAAGTCGCGGAATACAACA
AGCATAAGAACGAAAACAGCTATGTCAATGAAGCGATTAGTAAAAACCTAGTGTTCGATCAATCTGTCGT
GACGAAAGACACTAAAATTTCGTCGATTAAAGGCGGAAAATTTATCAAAGCAACTGATTTTAATAAAGTA
AATGCAGGGGATTCAAAAGATATCTTTACAAAATTACGGAAAGATATGGGTGGGAAAGCTACTGGCAACT
TCCAGAATTCCTTTGTAAAAGAGGCAAATCTTGGGTCTAATGGTGGGTATGCGGTTCTTTTAGAAAAAAA
TAAACCAGTGACAGTGACCTATACAGGACTAAACGCTAGTTATTTAGGACGTAAAATTACAAAAGCAGAA
TTTGTTTATGAACTACAATCCTCACCAAGCCAAAGTGGAACGTTAAATGCAGTATTTTCAAACGATCCGA
TTATCACAGCTTTTATTGGTACAAACAGAGTCAATGGTAAGGATGTTAAAACACGCTTAACGATTAAGTT
CTTTGATGCGTCAGGTAAAGAAGTACTACCAGATAAAGATAGTCCATTTGCGTATGCGCTGTCTTCTTTA
AATTCAAGTTTAACGAATAAAGGTGGCCATGCGGAATTTGTTTCTGATTTTGGGGCCAACAATGCGTTCA
AATACATTAATGGCTCATATGTGAAAAAACAAGCGGATGGAAAATTTTACTCACCGGAAGATATTGACTA
TGGCACAGGACCTTCTGGATTGAAAAATAGTGATTGGGACGCTGTAGGGCACAAGAATGCGTACTTTGGT
TCAGGTGTAGGTCTAGCTAATGGACGTATTTCCTTTTCTTTTGGTATGACAACAAAAGGAAAAAGTAATG
TGCCTGTATCTAGTGCGCAATGGTTTGCCTTTAGCACTAACTTAAATGCGCAATCAGTGAAGCCTATTTT
CAATTATGGGAATCCAAAAGAACCAGAAAAAGCAACGATTGAATTTAATGGATACAAAGCCAATGTCGTT
CCTGTTCTTGTTCCGAACAAAGAAGTCACTGATGGTCAGAAAAATATCAATGATTTAAATGTGAAACGTG
GCGACTCTTTACAATACATTGTGACAGGGGATACAACAGAACTTGCTAAAGTAGATCCAAAAACAGTAAC
AAAACAAGGGATTCGAGATACATTTGATGCAGAAAAAGTGACGATTGATTTATCCAAAGTGAAAGTTTAT
CAAGCAGACGCAAGTCTGAACGAAAAAGACTTAAAAGCAGTTGCTGCAGCGATTAATTCAGGAAAAGCGA
AAGACGTGACTGCTTCTTATGACCTCAATTTAGATCAAAACACCGTCACAGCAATGATGAAAACCAACGC
GGACGGCTCTGTTGTTTTAGCAATGGGGTATAAATATTTACTTGTCTTGCCGTTTGTAGTGAAAAATGTA
GAAGGCGATTTTGAAAATACAGCTGTTCAGCTGACAAATGATGGGGAAACGGTAACAAACACAGTTATCA
ATCATGTGCCAAGTAGCAACCCTTCCAAAGACGTAAAAGCAGATAAAAACGGTACAGTTGGCAGTGTCTC
TCTACATGATAAAGATATTCCGTTACAAACAAAAATTTATTATGAAGTGAAATCTTCCGAACGTCCAGCC
AACTATGGCGGAATCACAGAAGAATGGGGCATGAATGATGTGTTGGACACGACCCATGATCGTTTCACAG
GGAAATGGCACGCTATTACGAATTATGACCTTAAAGTAGGGGACAAAACGCTAAAAGCAGGAACAGATAT
TTCTGCCTACATTCTTTTAGAAAATAAAGACAATAAAGACTTGACGTTTACGATGAATCAAGCATTATTG
GCCGCCTTAAATGAAGGAAGCAATAAAGTAGGCAAACAAGCTTGGTCTGTGTATCTGGAAGTCGAACGGA
TTAAAACAGGTGACGTAGAAAACACGCAAACAGAAAACTACAACAAAGAGCTTGTTCGTTCTAATACGGT
GGTGACGCATACACCTGATGATCCAAAACCAACCAAAGCCGTTCATAACAAGAAAGGGGAAGACATTAAT
CATGGAAAAGTGGCTCGTGGTGATGTTCTTTCTTATGAAATGACTTGGGACTTAAAAGGGTACGATAAAG
ACTTTGCCTTTGATACAGTCGATCTTGCGACAGGCGTTTCTTTCTTCGATGATTACGATGAAACGAAAGT
GACACCAATTAAAGACTTACTTCGTGTCAAAGATTCTAAAGGGGTAGACATTACGAACCAGTTCACGATC
TCATGGGACGATGCCAAAGGCACGGTGACGATTTCTGCCAAAGACCCACAAGCCTTTATTCTAGCGTATG
GTGGGCAAGAATTGCGTGTAACACTCCCTACAAAAGTCAAAGCTGATGTTTCTGGGGATGTTTATAATTC
AGCGGAACAAAATACATTTGGCCAACGAATTAAAACCAATACTGTTGTCAACCATATTCCAAAAGTGAAT
CCTAAAAAGGATGTGGTCATTAAAGTTGGTGACAAACAAAGTCAAAATGGTGCCACAATCAAATTAGGGG
AGAAGTTCTTCTATGAATTTACAAGTAGTGACATTCCTGCAGAATACGCTGGAGTTGTGGAAGAATGGTC
GATTAGCGATAAACTAGACGTCAAACATGACAAATTTAGTGGACAATGGTCTGTGTTTGCCAATTCTAAT
TTTGTTTTAGCAGATGGAACCAAAGTGAATAAAGGGGACGACATTTCGAAACTATTCACGATGACCTTTG
ACAAAGGGGTAGTGAAAATCACGGCCAGTCAAGCCTTTTTGGATGCGATGAATCTAAAAGAAAACAAAAA
CGTTGCACACTCATGGAAAGCGTTCATTGGTGTAGAACGAATTGCGGCAGGAGACGTTTACAACACAATC
GAAGAATCTTTCAACAATGAGAAGATTAAAACGAATACGGTAGTGACACATACGCCAGAAAAACCACAAA
CACCACCAGAAAAAACAGTGATTGTACCACCAACACCAAAAACACCGCAAGCACCAGTAGAGCCATTAGT
GGTAGAAAAGGCAAGTGTAGTGCCAGAATTGCCGAAAACAGGCGAAAAACAAAATGTCTTATTAACGGTA
GTTGGTAGTTTAGCCGCAATGCTTGGCTTAGCAGGCTTAGGCTTTAAACGTAGAAAAGAAACAAAATA
Protein Sequence 
>gi|58616135|ref|YP_195774.1| PrgB [Enterococcus faecalis]
MNQQTEVKKRFKMYKAKKHWIVAPILFLGVLGVVGLATDNVQAAELDTQPGSTTVHPDNPDPQLGSATPN
TAVSEESAVQKDTTSQPTKAEEVASEKNGAEQSSATPNDTTNVQQPTVGAEKSAQEQPVVSPETTNEPLG
QPTEVAPAENEANKSTSILKEFETPDVDKAVDEAKKDPNITVVEKPAEDLGNVSSKDLAAKEKEVDQLQK
EQAKKIAQQAAELKAKNEKIAKENAEIAAKNKAEKEPYEKEVAEYNKHKNENSYVNEAISKNLVFDQSVV
TKDTKISSIKGGKFIKATDFNKVNAGDSKDIFTKLRKDMGGKATGNFQNSFVKEANLGSNGGYAVLLEKN
KPVTVTYTGLNASYLGRKITKAEFVYELQSSPSQSGTLNAVFSNDPIITAFIGTNRVNGKDVKTRLTIKF
FDASGKEVLPDKDSPFAYALSSLNSSLTNKGGHAEFVSDFGANNAFKYINGSYVKKQADGKFYSPEDIDY
GTGPSGLKNSDWDAVGHKNAYFGSGVGLANGRISFSFGMTTKGKSNVPVSSAQWFAFSTNLNAQSVKPIF
NYGNPKEPEKATIEFNGYKANVVPVLVPNKEVTDGQKNINDLNVKRGDSLQYIVTGDTTELAKVDPKTVT
KQGIRDTFDAEKVTIDLSKVKVYQADASLNEKDLKAVAAAINSGKAKDVTASYDLNLDQNTVTAMMKTNA
DGSVVLAMGYKYLLVLPFVVKNVEGDFENTAVQLTNDGETVTNTVINHVPSSNPSKDVKADKNGTVGSVS
LHDKDIPLQTKIYYEVKSSERPANYGGITEEWGMNDVLDTTHDRFTGKWHAITNYDLKVGDKTLKAGTDI
SAYILLENKDNKDLTFTMNQALLAALNEGSNKVGKQAWSVYLEVERIKTGDVENTQTENYNKELVRSNTV
VTHTPDDPKPTKAVHNKKGEDINHGKVARGDVLSYEMTWDLKGYDKDFAFDTVDLATGVSFFDDYDETKV
TPIKDLLRVKDSKGVDITNQFTISWDDAKGTVTISAKDPQAFILAYGGQELRVTLPTKVKADVSGDVYNS
AEQNTFGQRIKTNTVVNHIPKVNPKKDVVIKVGDKQSQNGATIKLGEKFFYEFTSSDIPAEYAGVVEEWS
ISDKLDVKHDKFSGQWSVFANSNFVLADGTKVNKGDDISKLFTMTFDKGVVKITASQAFLDAMNLKENKN
VAHSWKAFIGVERIAAGDVYNTIEESFNNEKIKTNTVVTHTPEKPQTPPEKTVIVPPTPKTPQAPVEPLV
VEKASVVPELPKTGEKQNVLLTVVGSLAAMLGLAGLGFKRRKETK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: prgB mutant is attenuated in rabbit model of endocarditis (Chuang et al., 2009).
References
Chuang et al., 2009: Chuang ON, Schlievert PM, Wells CL, Manias DA, Tripp TJ, Dunny GM. Multiple functional domains of Enterococcus faecalis aggregation substance Asc10 contribute to endocarditis virulence. Infection and immunity. 2009; 77(1); 539-548. [PubMed: 18955479].