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asa1 |
| Victor ID |
4785 |
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Gene Name |
asa1 |
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Sequence Strain (Species/Organism) |
Enterococcus faecalis V583 |
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NCBI Gene ID |
1202219
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NCBI Protein GI |
29377844
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Locus Tag |
EFA0047 |
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Genbank Accession |
AE016833 |
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Protein Accession |
NP_816972 |
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Taxonomy ID |
226185
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Plasmid No |
pTEF1 |
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Gene Starting Position |
35116 |
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Gene Ending Position |
39006 |
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Gene Strand (Orientation) |
- |
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Protein Name |
aggregation substance Asa1 |
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Protein pI |
6.21 |
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Protein Weight |
129983.83 |
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Protein Length |
1296 |
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Protein Note |
similar to GB:J03600, GB:J03571, SP:P09917, PID:187167, PID:187169, PID:187193, PID:388525, GB:J03600, GB:J03571, SP:P09917, PID:187167, PID:187169, PID:187193, and PID:388525; identified by sequence similarity; putative |
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DNA Sequence |
>gi|29377803:35116-39006 Enterococcus faecalis V583 plasmid pTEF1, complete sequence
ATTATTTTGTTTCTTTTCTACGTTTAAAGCCTAAGCCTGCTAAGCCAAGCATTGCGGCTAAACTACCAGC
TACCGTTAATAAGACATTTTGTTTTTCGCCTGTTTGCGGCAATTCTGGCACCACACTTGCCTTTTCTACC
ACTAATGGCTCTACTGGTGCTTGCGGTGTTTTTGGTGTTGGTGGTACAATCACTGTTTTTTCTGGTGGCG
TTTGTGGTTTTTCTGGCGTATGCGTCACTACCGTATTAGTTTTAATCTTCTCATTGTTGAAAGATTCTTC
GATTGTGTTGTAAACGTCTCCTGCCGCAATTCGTTCTACACCAATGAACGCTTTCCATGAGTGTGCAACG
TTTTTGTTTTCTTTTAGATTCATCGCATCTAAAAAGGCTTGACTGGCTGTGATTTTCACTACCCCTTGTT
CAAAGGTCATCGTGAATAGTTTCGAAATGTCGTCCCCTTTATTCACTTTGGTTCCGTCTGCTAAGACAAA
CGTAGAATTGGCAAACACAGACCATTGGCCACTAAATTTGTCATGTTTGACGTCTAGTTTATCGCTAATC
GACCATTCTTCCACAATACCAGCGTATTCTGCAGGAATGTCACTACTTGTAAATTCATAGAAGAATTTCT
CCCCTAATTTGATTGTGGCACCATTTTGACTTTGTTTATCACCGACTTTAATAACCACGTCTTTTTTAGG
GTTCACTTTTGGAATATGGTTGACAACGGTATTGGTTTTAATTCGTTGACCAAATGTATTTTGTTCCGCT
AAATTATACACATCACCAGAAACATTGGCTTTAACTTTTGTTGGTAAAGTTACACGTAATTCTTGCCCAC
CATGCGCCAAAATAAAGGCTTGTGGGTCTTTGGCAGAAATCGTCACCGTGCCTTTGGCATCATCCCAAGA
GATCGTGAACTGGTTCGTAATGTCTTCCCCTTTAGAATCTTTGACACGAAGTAAGTCTTTGATTGGTGTC
ACCTTCGTTTCATCGTAATCATCGAAGAAAGAAACGCCTGTCGCAAGATCGACTGTATCAAAGGCAAAGT
CCTTATCGTACCCTTTTAAGTCCCAAGTCATTTCATAAGAAAGAACATCACCACGAGCCACTTTTCCATG
ATTAATGTCTTCCCCTTTTTTGTTATGAACGGCTTTGGTTGGTTTTGGATCATCAGGCGTATGTGTCACC
ACCGTATTAGAACGAACAAGCTCTTTGTTGTAGTTTTCTGTTTGCGTGTTTTCTACGTCACCTGTTTTGA
TCCGTTCGACTTCCAGATACACAGACCAAGCTTGTTTGCCTACTTTATTGCTTCCTTCATTTAACGCTGC
CAATAATGCTTGATTCATTGTAAACGTCAAGTCTTTATTGTCTTTGTTTTCTAAAAGAATGTAGGCAGAA
ATATCTGTTCCTGCTTTTAACGTTTTATCCCCTACTTTAAGGTCATAGTTCGTAATAGCGTGCCATTTTC
CTGTGAAACGATCATGGGTCGTGTCCAAGACATCATTCATGCCCCATTCTTCTGTGATTCCGCCATAGTT
GGCTGGACGTTCGGAAGATTTCACTTCATAATAAATTTTTGTTTGTAACGGAATATCTTTATCATGTAGA
GAAACACTGCCAACTGTACCGTTTTTATCTGCTTTTACATCTTTGGAAGGATTACTACCTGGCACATGGT
TAATCACTGTATTTGTTACCGTTTCCCCATCGTTTGTTAATTGAACAGCTGTATTTTCAAAATCGCCTTC
TACATTTTTCACTACAAATGGCAAGACAAGTAAATATTTATACCCCATTGCTAAAACAACAGAGTCGTCT
GCGTTGGTTTTCATCATTGCTGTAACGGTGTTTTGGTCTAAATGAAGGTCATAAGAAGCGGTCACGTCTT
TAGCTTTTCCTGAATTAATTGCTGCAGCAACAGCTTTTAAGTCTTTTTCGTTTAGACTTGCGTCTGCTTG
ATAAACTTTCACTTTGGATAAATCAATCGTCACTTTTTCTGCATCAAAGGTATCTCGAATCCCTTGTTTT
GTTACTGTTTTTGGATCTACTTTGGCAAGTTCTGTCGTATCCCCTGTCACAATGTATTGTAAAGAATCGC
CACGTTTCACATTTAAATCATTGATATTTTTCTGGCCATCAGTGACTTCTTTATTCGGAACAAGAACAGG
AACCACATTGGCTTTGTATCGATTGAATTCAATCGTTGCTTTTTCTGGTTGCTTTGGACGTCCTTTTTCT
TGATAAGGCGTAATTGATTTTGCTTTTAAATCCGTATTAAATGCGAACCACATCGAATTTCCGTCATACC
CTGGATTGTTAACAATTTCATTCCCGAAAGTGAATTTAATTCTATTTGGTGTTGAAATAACAGTTGCGCC
AATATATTCTTTGCCTTGAACTGCTTCCCAGTCACTTATTGAAATCCCATTCGTCCCTACATCAATATCC
GTTTTAGAATAAACTTTATTTCCATGACGAGCTACTTTTGATCCATTAATTTCATGAACAGTATCCGTGT
TTCCTACTTTTACGAACTCATACGTAATGTTTTCACCACGTGAATTTAATGAAGCACCTGAAAATACAAA
TGGATTCTCTTTCGTTGGCAAGATTTCTTTGCCATCTTCTCCAAAGAAGCGAACGAGCATTTCAATCTCA
GCACCAGCCTTCTTTGTACGAGGGTCAATGTTAATTCCATAGACAATTGTGGCCACTGGATCATCATGTA
AGAAAGCATTCAATCGACCTTTTGAATCAGGTGTGGCCTTCACTGTATATTGGAATTCAGCACTAGCAAT
TTTTTTACCCAAATAACTAGCATTCAAATTGCCATAGGTAATAGTTACTGGTTGATTTTTGTGAAGAACA
ACCAATGTTCCTCCTGCACCGTTATTATAATAAAAATGTGCTTTTTTCGAGTCTTTAGTTGTTAACCCGC
TTGAATCTACACTAAGCATACTGATAAGTAATTTTTTATCTTTATGTTTATCAGTTAGTTTTTTAGCGTC
TATATATTCTGCAGCTTTTACAGAAACAACTTTGGAATTTTTTGTTGCTTCACGATCGAAAATTAGCGTT
TTATTTACTGGTTTTGCTACATAGCCATTTTCATTTTTATGTTTGTTGTATTCCGCGACTTCTTTCTCGT
AGCGTTCTTTTTCCGCTTTGTTTTTTGCCGCAATTTCTGCATTTTCTTTGGCAATTTTTTCATTTTTGGC
TTTTAATTCAGCTGCTTGTTGCGCAATCTTTTTCGCTTGTTCTTTTTGTAGTTGGTCTACTTCTTTTTCT
TTTGCAGCTAAATCTTTAGAAGAAACGTTGCCTAAGTCTTCTGCTGGTTTTTCAACAACGGTAATGTTTG
GATCTTTTTTTGCTTCATCAACTGCTTTGTCAACGTCTGGTGTTTCAAATTCTTTAGGAATGGACGTTGA
TTTATTCGCTTCATTTTCAGCTGGTGCAACTTCTGTTGGCTGCCCTAGAGGTTCATTGGTTGTTTCAGGG
CTTACTACTGGTTGTTCTTGTGCTGATTTTTCTGCTCCTACTGTTGGTTGTTGCGCGTTTGTGGTATCAT
TTGGAGTAGCTGAACTCTGTTCAGCTCCATTTTTTTCAGACGCTACTTCTTCTACTTTGGTCGGTTGAGA
AGTAGTGTCTTTTTGTACTGTTGCTTCTTCAGTTACTGCTGTCTTAGGTGTTGTACTACCTACCTGCGGA
TCGGGGTTATCGGGTTGCACCGTCGTTGTTCCTGGTTGCGTATCTAATTCCGCAGCTTGTACATCATCAG
TAGCTAATCCTACAACTCCTAACACACCTATAAAAAGAATAGGGGCTACCACCCAATGCTTCTTTGCCTT
ATACATTTTAAAACGTTTCTTTACTTCTGTTTGTTGCTTCA
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Protein Sequence |
>gi|29377844|ref|NP_816972.1| aggregation substance Asa1 [Enterococcus faecalis V583]
MKQQTEVKKRFKMYKAKKHWVVAPILFIGVLGVVGLATDDVQAAELDTQPGTTTVQPDNPDPQVGSTTPK
TAVTEEATVQKDTTSQPTKVEEVASEKNGAEQSSATPNDTTNAQQPTVGAEKSAQEQPVVSPETTNEPLG
QPTEVAPAENEANKSTSIPKEFETPDVDKAVDEAKKDPNITVVEKPAEDLGNVSSKDLAAKEKEVDQLQK
EQAKKIAQQAAELKAKNEKIAKENAEIAAKNKAEKERYEKEVAEYNKHKNENGYVAKPVNKTLIFDREAT
KNSKVVSVKAAEYIDAKKLTDKHKDKKLLISMLSVDSSGLTTKDSKKAHFYYNNGAGGTLVVLHKNQPVT
ITYGNLNASYLGKKIASAEFQYTVKATPDSKGRLNAFLHDDPVATIVYGINIDPRTKKAGAEIEMLVRFF
GEDGKEILPTKENPFVFSGASLNSRGENITYEFVKVGNTDTVHEINGSKVARHGNKVYSKTDIDVGTNGI
SISDWEAVQGKEYIGATVISTPNRIKFTFGNEIVNNPGYDGNSMWFAFNTDLKAKSITPYQEKGRPKQPE
KATIEFNRYKANVVPVLVPNKEVTDGQKNINDLNVKRGDSLQYIVTGDTTELAKVDPKTVTKQGIRDTFD
AEKVTIDLSKVKVYQADASLNEKDLKAVAAAINSGKAKDVTASYDLHLDQNTVTAMMKTNADDSVVLAMG
YKYLLVLPFVVKNVEGDFENTAVQLTNDGETVTNTVINHVPGSNPSKDVKADKNGTVGSVSLHDKDIPLQ
TKIYYEVKSSERPANYGGITEEWGMNDVLDTTHDRFTGKWHAITNYDLKVGDKTLKAGTDISAYILLENK
DNKDLTFTMNQALLAALNEGSNKVGKQAWSVYLEVERIKTGDVENTQTENYNKELVRSNTVVTHTPDDPK
PTKAVHNKKGEDINHGKVARGDVLSYEMTWDLKGYDKDFAFDTVDLATGVSFFDDYDETKVTPIKDLLRV
KDSKGEDITNQFTISWDDAKGTVTISAKDPQAFILAHGGQELRVTLPTKVKANVSGDVYNLAEQNTFGQR
IKTNTVVNHIPKVNPKKDVVIKVGDKQSQNGATIKLGEKFFYEFTSSDIPAEYAGIVEEWSISDKLDVKH
DKFSGQWSVFANSTFVLADGTKVNKGDDISKLFTMTFEQGVVKITASQAFLDAMNLKENKNVAHSWKAFI
GVERIAAGDVYNTIEESFNNEKIKTNTVVTHTPEKPQTPPEKTVIVPPTPKTPQAPVEPLVVEKASVVPE
LPQTGEKQNVLLTVAGSLAAMLGLAGLGFKRRKETK
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Molecule Role |
Virulence factor |
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Molecule Role Annotation |
MUTATION: asa1 deletion mutant has reduced adherence to macrophages, and an AS negative strain had decreased survival in macrophages compared to a AS positive strain (Süssmuth et al., 2000).
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| References |
Süssmuth et al., 2000: Süssmuth SD, Muscholl-Silberhorn A, Wirth R, Susa M, Marre R, Rozdzinski E. Aggregation substance promotes adherence, phagocytosis, and intracellular survival of Enterococcus faecalis within human macrophages and suppresses respiratory burst. Infection and immunity. 2000; 68(9); 4900-4906. [PubMed: 10948103].
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