| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
oppF |
Staphylococcus aureus subsp. aureus N315 |
1122975
|
|
15925909
|
SA0198 |
|
NP_373442.1 |
oligopeptide transport ATP-binding protein |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
oppD |
Staphylococcus aureus subsp. aureus N315 |
1123664
|
|
15926577
|
SA0847 |
|
NP_374110.1 |
oligopeptide transport system ATP-binding protein OppD homologue |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
purL |
Staphylococcus aureus subsp. aureus N315 |
1123744
|
|
15926655
|
SA0921 |
|
NP_374188.1 |
phosphoribosylformylglycinamidine synthase II |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
SA1062 |
Staphylococcus aureus subsp. aureus N315 |
1123893
|
|
15926802
|
SA1062 |
|
NP_374335.1 |
hypothetical protein |
Virulence factor |
MUTATION: SA1062 (stp1) mutant is attenuated in mice [Ref6945:Burnside et al., 2010]. |
20552019
|
|
|
SA1063 |
Staphylococcus aureus subsp. aureus N315 |
1123894
|
|
15926803
|
SA1063 |
|
NP_374336.1 |
protein kinase |
Virulence factor |
MUTATION: stk1 (SA1063) mutant is attenuated in mice [Ref6946:Débarbouillé et al., 2009]. |
19395491
|
|
|
recA from Staphylococcus aureus subsp. aureus N315 |
Staphylococcus aureus subsp. aureus N315 |
1123959
|
|
15926868
|
SA1128 |
|
NP_374401.1 |
recombinase A |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
thrB |
Staphylococcus aureus subsp. aureus N315 |
1124002
|
|
15926911
|
SA1166 |
|
NP_374444.1 |
homoserine kinase homolog |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
citB |
Staphylococcus aureus subsp. aureus N315 |
1124021
|
|
15926930
|
SA1184 |
|
NP_374463.1 |
aconitate hydratase |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
msrA |
Staphylococcus aureus subsp. aureus N315 |
1124032
|
|
15926941
|
SA1194 |
|
NP_374474.1 |
peptide methionine sulfoxide reductase homolog |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
msrR |
Staphylococcus aureus subsp. aureus N315 |
1124033
|
|
15926942
|
SA1195 |
|
NP_374475.1 |
peptide methionine sulfoxide reductase regulator MsrR |
Virulence factor |
MUTATION: mutant displayed reduced ability to colonize and reduced virulence in nematodes and rat endocarditis [Ref6947:Hübscher et al., 2009]. |
19459977
|
|
|
trpD |
Staphylococcus aureus subsp. aureus N315 |
1124040
|
|
15926949
|
SA1201 |
|
NP_374482.1 |
anthranilate phosphoribosyltransferase |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
trpB |
Staphylococcus aureus subsp. aureus N315 |
1124043
|
|
15926952
|
SA1204 |
|
NP_374485.1 |
tryptophan synthase subunit beta |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
trpA |
Staphylococcus aureus subsp. aureus N315 |
1124044
|
|
15926953
|
SA1205 |
|
NP_374486.1 |
tryptophan synthase subunit alpha |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
femA from Staphylococcus aureus subsp. aureus N315 |
Staphylococcus aureus subsp. aureus N315 |
1124045
|
|
15926954
|
SA1206 |
|
NP_374487.1 |
factor essential for expression of methicillin resistance |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
femB |
Staphylococcus aureus subsp. aureus N315 |
1124046
|
|
15926955
|
SA1207 |
|
NP_374488.1 |
FemB protein |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
opp-2C from Staphylococcus aureus subsp. aureus N315 |
Staphylococcus aureus subsp. aureus N315 |
1124052
|
|
15926961
|
SA1213 |
|
NP_374494.1 |
oligopeptide transporter permease |
Virulence factor |
MUTATION: mutant attenuated in murine infection model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
asd |
Staphylococcus aureus subsp. aureus N315 |
1124065
|
|
15926974
|
SA1226 |
|
NP_374507.1 |
aspartate semialdehyde dehydrogenase |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
lysA |
Staphylococcus aureus subsp. aureus N315 |
1124071
|
|
15926980
|
SA1232 |
|
NP_374513.1 |
diaminopimelate decarboxylase |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
braB from Staphylococcus aureus subsp. aureus N315 |
Staphylococcus aureus subsp. aureus N315 |
1124078
|
|
15926987
|
SA1239 |
|
NP_374520.1 |
branched-chain amino acid carrier protein |
Virulence factor |
MUTATION: mutant attenuated in murine infection model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
odhB |
Staphylococcus aureus subsp. aureus N315 |
1124083
|
|
15926992
|
SA1244 |
|
NP_374525.1 |
dihydrolipoamide succinyltransferase |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
SA1262 |
Staphylococcus aureus subsp. aureus N315 |
1124100
|
|
15927010
|
SA1262 |
|
NP_374543.1 |
hypothetical protein |
Virulence factor |
MUTATION: SA1262 (cvfC3) mutant is attenuated in silkworms [Ref6949:Ikuo et al., 2010]. |
20347953
|
|
|
dinG from Staphylococcus aureus subsp. aureus N315 |
Staphylococcus aureus subsp. aureus N315 |
1124126
|
|
15927036
|
SA1288 |
|
NP_374569.1 |
ATP-dependent DNA helicase dinG |
Virulence factor |
MUTATION: attenuated in murine model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
SA1453 |
Staphylococcus aureus subsp. aureus N315 |
1124296
|
|
15927206
|
SA1453 |
|
NP_374739.1 |
hypothetical protein |
Virulence factor |
MUTATION: SA1453 (cymR) mutant is attenuated in mice [Ref6950:Soutourina et al., 2010]. |
20485570
|
|
|
clpX |
Staphylococcus aureus subsp. aureus N315 |
1124343
|
|
15927253
|
SA1498 |
|
NP_374786.1 |
ATP-dependent protease ATP-binding subunit ClpX |
Virulence factor |
MUTATION: attenuated in murine model [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
fbp from Staphylococcus aureus subsp. aureus N315 |
Staphylococcus aureus subsp. aureus N315 |
1125231
|
|
15928095
|
SA2304 |
|
NP_375628.1 |
fructose-bisphosphatase |
Virulence factor |
MUTATION: attenuated in murine model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
braB from Staphylococcus aureus subsp. aureus Mu50 |
Staphylococcus aureus subsp. aureus Mu50 |
1121382
|
|
15924397
|
SAV1407 |
|
NP_371931.1 |
branched-chain amino acid carrier protein |
Virulence factor |
MUTATION: mutant attenuated in murine infection model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
mprF from Staphylococcus aureus subsp. aureus MRSA252 |
Staphylococcus aureus subsp. aureus MRSA252 |
2861306
|
|
49483553
|
SAR1372 |
|
YP_040777.1 |
hypothetical protein |
Virulence factor |
MUTATION: mprF mutant is attenuated in mice [Ref6951:Peschel et al., 2001]. |
11342591
|
|
|
opp-2C from Staphylococcus aureus subsp. aureus MW2 |
Staphylococcus aureus subsp. aureus MW2 |
1003381
|
|
21282998
|
MW1269 |
|
NP_646086.1 |
oligopeptide transporter permease |
Virulence factor |
MUTATION: mutant attenuated in murine infection model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
braB from Staphylococcus aureus subsp. aureus MW2 |
Staphylococcus aureus subsp. aureus MW2 |
1003409
|
|
21283026
|
MW1297 |
|
NP_646114.1 |
branched-chain amino acid carrier protein |
Virulence factor |
MUTATION: mutant attenuated in murine infection model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
dinG from Staphylococcus aureus subsp. aureus MW2 |
Staphylococcus aureus subsp. aureus MW2 |
1003457
|
|
21283074
|
MW1345 |
|
NP_646162.1 |
ATP-dependent DNA helicase dinG |
Virulence factor |
MUTATION: mutant attenuated in murine infection model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
mprF from Staphylococcus aureus RF122 |
Staphylococcus aureus RF122 |
3793454
|
|
82750952
|
SAB1216 |
|
YP_416693.1 |
hypothetical protein |
Virulence factor |
MUTATION: mprF mutant is attenuated in mice [Ref6951:Peschel et al., 2001]. |
11342591
|
|
|
recA from Staphylococcus aureus subsp. aureus NCTC 8325 |
Staphylococcus aureus subsp. aureus NCTC 8325 |
3919993
|
|
228937974
|
SAOUHSC_01262 |
|
YP_499795.2 |
recombinase A |
Virulence factor |
MUTATION: recA mutant is attenuated in mice [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
SAOUHSC_01373 |
Staphylococcus aureus subsp. aureus NCTC 8325 |
3920782
|
|
88195100
|
SAOUHSC_01373 |
|
YP_499900.1 |
methicillin resistance factor, FemA, putative |
Virulence factor |
MUTATION: femA mutant is attenuated in mice [Ref6944:Mei et al., 1997]. |
9383163
|
|
|
tilS |
Staphylococcus aureus subsp. aureus str. Newman |
5330252
|
|
151220683
|
NWMN_0471 |
|
YP_001331505.1 |
hypothetical protein |
Virulence factor |
MUTATION: mutant attenuated in a C. elegans-killing model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
fbp from Staphylococcus aureus subsp. aureus str. Newman |
Staphylococcus aureus subsp. aureus str. Newman |
5331488
|
|
151222626
|
NWMN_2414 |
|
YP_001333448.1 |
fructose-1,6-bisphosphatase |
Virulence factor |
MUTATION: mutant attenuated in a C. elegans-killing model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
ccpA |
Staphylococcus aureus subsp. aureus str. Newman |
5331715
|
|
151221841
|
NWMN_1629 |
|
YP_001332663.1 |
catabolite control protein A |
Virulence factor |
MUTATION: mutant displayed reduced replication and infection in murine model [Ref6986:Li et al., 2010]. |
20525824
|
|
|
pyrAA |
Staphylococcus aureus subsp. aureus str. Newman |
5332320
|
|
151221325
|
NWMN_1113 |
|
YP_001332147.1 |
carbamoyl phosphate synthase small subunit |
Virulence factor |
MUTATION: mutant attenuated in a Caenorhabditis elegans-killing model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
braB from Staphylococcus aureus subsp. aureus Mu3 |
Staphylococcus aureus subsp. aureus Mu3 |
5560751
|
|
156979726
|
SAHV_1395 |
|
YP_001441985.1 |
branched-chain amino acid carrier protein |
Virulence factor |
MUTATION: mutant attenuated in murine infection model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
SAHV_0924 |
Staphylococcus aureus subsp. aureus Mu3 |
5560784
|
|
156979255
|
SAHV_0924 |
|
YP_001441514.1 |
hypothetical protein |
Virulence factor |
MUTATION: NagD mutant attenuated in C. Elegans-killing model [Ref6948:Begun et al., 2005]. |
15664928
|
|
|
mgrA |
Staphylococcus aureus subsp. aureus Mu3 |
5561057
|
|
156979014
|
SAHV_0683 |
|
YP_001441273.1 |
MarR family transcriptional regulator |
Virulence factor |
MUTATION: mutant showed less bacterial persistence in kidneys and attenuated virulence in mice [Ref6987:Jonsson et al., 2008]. |
18692591
|
|
|
isdH |
Staphylococcus aureus 04-02981 |
|
|
285817413
|
|
|
|
Cell surface receptor IsdH for hemoglobin-haptoglobin complexes |
Virulence factor |
MUTATION: Mutant showed attenuated virulence in mouse model [Ref7004:Visai et al., 2009].
. |
19246738
|
|
|
rsh |
Staphylococcus aureus |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: rsh mutant less virulent in animal model [Ref7005:Geiger et al., 2010].
|
20212088
|
|
|
Type 8 capsular polysaccharide (CP8) |
Staphylococcus aureus |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: In a mouse infection model of bacteremia, the CP8-overproducing strain persisted longer in the bloodstream, the liver, and the spleen in mice than the parent strain [Ref7299:Luong and Lee, 2002]. |
12065477
|
|
|
Type 5 capsular polysaccharide (CP5) |
Staphylococcus aureus |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: Wild type S. aureus with a CP5 capsule were more virulent in mice than CP5 mutants [Ref7305:Thakker et al., 1998]. |
9784520
|
|
|
aroA |
Staphylococcus aureus subsp. aureus ED98 |
8614197
|
|
269203089
|
SAAV_1451 |
CP001781 |
YP_003282358 |
3-phosphoshikimate 1-carboxyvinyltransferase |
Virulence factor |
MUTATION: An aroA mutant is attenuated in mice [Ref7355:Buzzola et al., 2006]. |
16714581
|
|
|
spa |
Staphylococcus aureus subsp. aureus str. Newman |
5332074
|
|
151220267
|
NWMN_0055 |
AP009351 |
YP_001331090 |
immunoglobulin G binding protein A precursor (protein A) |
Virulence factor |
An isogenic spa deletion variant S. aureus Newman Δspa was generated. After intraperitoneal challenge with 2 × 10^8 CFU of wild-type S. aureus Newman, 60% of animals succumbed to challenge. In contrast, animals infected with the isogenic mutant resulted in only 25% mortality. In addition, the spa mutant displayed a consistent survival defect when examined in naive mouse blood. These results suggest that SpA is a crucial virulence factor for lethal infections of S. aureus in mice [Ref7423:Kim et al., 2010]. |
20713595
|
|
|
hla |
Staphylococcus aureus subsp. aureus str. Newman |
5330660
|
|
151221285
|
NWMN_1073 |
AP009351 |
YP_001332107 |
alpha-hemolysin precursor |
Virulence factor |
Replacement of hla with the hla:erm allele completely abolished the ability of S. aureus LAC to cause lung infections in C57BL/6J mice [Ref7424:Bubeck Wardenburg et al., 2007]. |
18064027
|
