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isdH

Victor ID 4466
Gene Name isdH
Sequence Strain (Species/Organism) Staphylococcus aureus 04-02981
NCBI Protein GI 285817413
Other Database IDs CDD:132697
CDD:164062
CDD:155090
CDD:132993
Taxonomy ID 703339
Gene Strand (Orientation) ?
Protein Name Cell surface receptor IsdH for hemoglobin-haptoglobin complexes
Protein Length 891
Protein Note haptoglobin-binding heme uptake protein HarA; TIGR03658
Protein Sequence 
>gi|285817413|gb|ADC37900.1| Cell surface receptor IsdH for hemoglobin-haptoglobin complexes [Staphylococcus aureus 04-02981]
MNKHHPKLRSFYSIRKSTLGVASVIVSTLFLITSQHQAQAAENTNTSDKISENQNNNATTTQQPKDTNQT
QPATQPVITAKNYPAADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYT
KKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEET
NYDYTKLVFAKPIYNDPSLVKSDTNDAVVTNDQSSSDASNQTNTNTSNQNTSTTNNANNQPQATTNMSQP
AQPKSSANADQASSQPAHETNSNGNTNDKTNESSNQSDVNQQYPPADESLQDAIKNPAIIDKEHTADNWR
PIDFQMKNDKGERQFYHYASTVEPATVIFTKTGPVIELGLKTASTWKKFEVYEGDKKLPVELVSYDSDKD
YAYIRFPVSNGTRDVKIVSSIEYGENIHEDYDYTLMVFAQPITNNPDDYVDEETYNLQKLLAPYHKAKTL
ERQVYELEKLQEKLPEKYKAEYKKKLDQTRVELADQVKSAVTEFENVTPTNDQLTDLQEAHFVVFESEEN
SESVMDGFVEHPFYTATLNGQKYVVMKTKDDSYWKDLIVEGKRVTTVSKDPKNNSRTLIFPYIPDKAVYN
AIVKVVVANIGYEGQYHVRIINQDINTKDDDTSQNNTSEPLNVQTGQEGKVADTDVAENSSTATNPKDAS
DKADVIEPESDVVKDADNNIDKDVQHDVDHLSDMSDNNHFDKYDLKEMDTQIAKDTDRNVDNSVGMSSNV
DTDKDSNKNKDKVIQLAHIVDKNNHTGKAAKLDVVKQNYNNTDKVTDKKTTEHLPSDIHKTVDKTVKTKE
KAGTPSKENKLSQSKMLPKTGETTSSQSWWGLYALLGMLALFIPKFRKESK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Mutant showed attenuated virulence in mouse model (Visai et al., 2009).
.
References
Visai et al., 2009: Visai L, Yanagisawa N, Josefsson E, Tarkowski A, Pezzali I, Rooijakkers SH, Foster TJ, Speziale P. Immune evasion by Staphylococcus aureus conferred by iron-regulated surface determinant protein IsdH. Microbiology (Reading, England). 2009; 155(Pt 3); 667-679. [PubMed: 19246738].