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hla

Victor ID 5018
Gene Name hla
Sequence Strain (Species/Organism) Staphylococcus aureus subsp. aureus str. Newman
NCBI Gene ID 5330660
NCBI Protein GI 151221285
Locus Tag NWMN_1073
Genbank Accession AP009351
Protein Accession YP_001332107
Taxonomy ID 426430
Gene Starting Position 1176264
Gene Ending Position 1177223
Gene Strand (Orientation) -
Protein Name alpha-hemolysin precursor
Protein pI 9.19
Protein Weight 33988.38
Protein Length 319
DNA Sequence 
>gi|151220212:1176264-1177223 Staphylococcus aureus subsp. aureus str. Newman chromosome, complete genome
ATTAATTTGTCATTTCTTCTTTTTCCCAATCGATTTTATATCTTTCTGAAGAACGATCTATCCATTTATC
TTTAGTATTGGTACCTTTCCAATTTGTTGAAGTCCAGTGCAATTGGTAGTCATCACGAACTCGTTCGTAT
ATTACATCTATATTTGTTTGTTGTTTGGATGCTTTTCTATCCATAGTAATAACTGTAGCGAAGTCTGGTG
AAAACCCTGAAGATAATAGAGAACTTGCTTTGTTAGGATCAAGGAAGTTATCTGCTGCTTTCATAGAGCC
ATTTCTAGTTTTCATGAAAAGTTGATTGCCATATACCGGGTTCCAAGAATCTCTATCATATGGTCCCCAA
TTTTGATTCACCATATTGTTAAATATCACTTTCCAGCCTACTTTTTTATCAGTTGGGCTCTCTAAAATTG
TTTTGAAATCAGGTTGAACATATTTCAGTGTATGACCAATCGAAACATTTGCACCAATAAGGCCGCCAAT
TTTTCCTGTATCATCACCAGTAACATTACCGTTGAATCCATAAGTTAAAGTACTCATATACTCTTTTGTA
TCAATCGAATTTCTTGGATAGTAATCAGATATTTGAGCTACTTCATTATCAGGTAGTTGCAACTGTACCT
TAAAGGCTGAAGGCCAGGCTAAACCACTTTTGTTAGCACCTTCTTCGCTATAAACTCTATATTGACCAGC
AATGGTACCTTTCGTTCTAATAACTAGCAGTTTTTTATTATGATTTTTATCATCGATAAAACTATAAAAT
ACTTTTTTGTGCATGCCATTTTCTTTATCATAAGTGACTAAATCACCTGTTTTTACTGTAGTATTGCTTC
CAATATCTGTAGTACCGGTTTTAATATTAATATCAGAATCTGCGGCATTAGCGACAGGATTCATTAATAT
GGAACCTAGCAATAGTGTTGTTGTTACTGAGCTGACTATACGTGTTTTCA
Protein Sequence 
>gi|151221285|ref|YP_001332107.1| alpha-hemolysin precursor [Staphylococcus aureus subsp. aureus str. Newman]
MKTRIVSSVTTTLLLGSILMNPVANAADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFID
DKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMS
TLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDR
DSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRD
DYQLHWTSTNWKGTNTKDKWIDRSSERYKIDWEKEEMTN
Molecule Role Virulence factor
Molecule Role Annotation Replacement of hla with the hla:erm allele completely abolished the ability of S. aureus LAC to cause lung infections in C57BL/6J mice (Bubeck Wardenburg et al., 2007).
References
Bubeck Wardenburg et al., 2007: Bubeck Wardenburg J, Bae T, Otto M, Deleo FR, Schneewind O. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nature medicine. 2007; 13(12); 1405-1406. [PubMed: 18064027].