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spa

Victor ID 5017
Gene Name spa
Sequence Strain (Species/Organism) Staphylococcus aureus subsp. aureus str. Newman
NCBI Gene ID 5332074
NCBI Protein GI 151220267
Locus Tag NWMN_0055
Genbank Accession AP009351
Protein Accession YP_001331090
Taxonomy ID 426430
Gene Starting Position 73427
Gene Ending Position 74989
Gene Strand (Orientation) -
Protein Name immunoglobulin G binding protein A precursor (protein A)
Protein pI 5.49
Protein Weight 55441.75
Protein Length 520
DNA Sequence 
>gi|151220212:73427-74989 Staphylococcus aureus subsp. aureus str. Newman chromosome, complete genome
TTTATAGTTCGCGACGACGTCCAGCTAATAACGCTGCACCTAAGGCTAATGATAATCCACCAAATACAGT
TGTACCGATGAATGGATTTTCTTCACCAGTTTCTGGTAATGCTTGAGCTTTGTTAGCATCTGCATGGTTT
GCTGGTTGCTTCTTATCAACAACAAGTTCTTGACCAGGTTTGATCATGTTTTTATCAGCTAATTTGTTAT
CTGCAGCAATTTTGTCAGCAGTAGTGCCGTTTGCTTTTGCAATGTCATTTACTGTATCACCAGGTTTAAC
GACATGTACTCCGTTACCATCTTCTTTACCAGGTTTGTTGCCATCTTCTTTGCCAGGCTTGTTGCCGTCT
TCTTTACCAGGTTTTTTGTTGTCTTCTTTACCAGGCTTGTTGCCATCTTCTTTACCAGGTTTTTTGTTGT
CTTCTTTACCAGGCTTGTTGCCGTCTTCTTTGCCAGGCTTGTTGTTGTCTTCTTTACCAGGCTTGTTGTT
GTCTTCTTTGCCAGGCTTGTTATTGTCTTCTTTGCCAGGCTTGTTATTGTCTTCCTCTTTTGGTGCTTGA
GCATCGTTTAGCTTTTTAGCTTCTGCTAAAATTTCTTTGCTCACTGAAGGATCGTCTTTAAGGCTTTGGA
TGAAGCCGTTACGTTGTTCTTCAGTTAAGTTAGGTAAATGTAAAATTTCATAGAAAGCATTTTGTTGTTC
TTTGTTGAATTTGTTGTCAGCTTTTGGTGCTTGAGCATCATTTAGCTTTTTAGCTTCTGCTAAAAGGTTA
GCGCTTTGGCTTGGGTCATCTTTTAGGCTTTGGATGAAACCATTGCGTTGTTCTTCGTTTAAGTTAGGTA
AATGTAAGATTTCATAGAAAGCATTTTGTTGTTCTTTGTTGAATTTGTTATCCGCTTTCGGTGCTTGAGA
TTCATTTAACTTTTTAGCTTCTGACAATAGGTTAGCACTTTGGCTTGGGTCATCTTTTAAGCTTTGGATG
AAACCATTGCGTTGTTCTTCGTTTAAGTTAGGCATATTCAAGATTTCATAGAAAGCATTTTGTTGTTCTT
TGTTGAAATTGTTATCAGCTTTCGGTGCTTGAGATTCGTTTAATTTTTTAGCTTCACCTAAAACGTTAGT
GCTTTGGCTTGGGTCGTCTTTAAGACTTTGAATGAAGCCGTTACGTTGCGCTTCGTTTAAGTTAGGCATG
TTCAAGATTTCATAGAAGGCGCTTTGTTGATCTTTGTTGAAGTTATTTTGTTGCGCATCAGCTTTTGGAG
CTTGAGAGTCATTAAGTTTTTGAGCTTCACCTAAAACGTTAGCACTTTGGCTTGGATCATCTTTAAGGCT
TTGGATAAAACCATTGCGTTGATCAGCATTTAAGTTAGGCATATTTAAGACTTGATAAAAAGCATTTTGT
TGAGCTTCATCGTGTTGCGCAGCATTTGCAGCAGGTGTTACGCCACCAGATATAAGTAATGTACCTAAAG
TTACAGATGCAATACCTACACCTAGTTTACGAATTGAATAAATGTTTTTCTTTTTCAAATTAATACCCCC
TGTATGTATTTGTAAAGTCATCA
Protein Sequence 
>gi|151220267|ref|YP_001331090.1| immunoglobulin G binding protein A precursor (protein A) [Staphylococcus aureus subsp. aureus str. Newman]
MMTLQIHTGGINLKKKNIYSIRKLGVGIASVTLGTLLISGGVTPAANAAQHDEAQQNAFYQVLNMPNLNA
DQRNGFIQSLKDDPSQSANVLGEAQKLNDSQAPKADAQQNNFNKDQQSAFYEILNMPNLNEAQRNGFIQS
LKDDPSQSTNVLGEAKKLNESQAPKADNNFNKEQQNAFYEILNMPNLNEEQRNGFIQSLKDDPSQSANLL
SEAKKLNESQAPKADNKFNKEQQNAFYEILHLPNLNEEQRNGFIQSLKDDPSQSANLLAEAKKLNDAQAP
KADNKFNKEQQNAFYEILHLPNLTEEQRNGFIQSLKDDPSVSKEILAEAKKLNDAQAPKEEDNNKPGKED
NNKPGKEDNNKPGKEDNNKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDNKKPGKEDGNKPGKEDGNKPGK
EDGNGVHVVKPGDTVNDIAKANGTTADKIAADNKLADKNMIKPGQELVVDKKQPANHADANKAQALPETG
EENPFIGTTVFGGLSLALGAALLAGRRREL
Molecule Role Virulence factor
Molecule Role Annotation An isogenic spa deletion variant S. aureus Newman ÃŽâ€spa was generated. After intraperitoneal challenge with 2 × 108 CFU of wild-type S. aureus Newman, 60% of animals succumbed to challenge. In contrast, animals infected with the isogenic mutant resulted in only 25% mortality. In addition, the spa mutant displayed a consistent survival defect when examined in naive mouse blood. These results suggest that SpA is a crucial virulence factor for lethal infections of S. aureus in mice (Kim et al., 2010).
COG COG5271R, under R: General function prediction only
References
Kim et al., 2010: Kim HK, Cheng AG, Kim HY, Missiakas DM, Schneewind O. Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice. The Journal of experimental medicine. 2010; 207(9); 1863-1870. [PubMed: 20713595].