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citB

Victor ID 4293
Gene Name citB
Sequence Strain (Species/Organism) Staphylococcus aureus subsp. aureus N315
NCBI Gene ID 1124021
NCBI Protein GI 15926930
Locus Tag SA1184
Protein Accession NP_374463.1
Other Database IDs UniProtKB-ID: ACON_STAAN
UniRef100: UniRef100_Q5HG69
UniRef90: UniRef90_Q5HG69
UniRef50: UniRef50_Q6GH55
UniParc: UPI00000549F4
EMBL: BA000018
EMBL-CDS: BAB42442.1
RefSeq_NT: NC_002745.2
EnsemblGenome: EBSTAG00000001080
EnsemblGenome_TRS: EBSTAT00000001080
EnsemblGenome_PRO: EBSTAP00000001080
GenomeReviews: BA000018_GR
KEGG: sau:SA1184
eggNOG: COG1048
HOGENOM: HBG289738
OMA: YSKAQGM
ProtClustDB: PRK09277
BioCyc: SAUR158879:SA1184-MONOMER
Taxonomy ID 158879
Gene Starting Position 1349288
Gene Ending Position 1351993
Gene Strand (Orientation) +
Protein Name aconitate hydratase
DNA Sequence 
>gi|29165615:1349288-1351993 Staphylococcus aureus subsp. aureus N315, complete genome
AATGGCTGCAAATTTTAAAGAGCAATCAAAAAAACATTTTGACTTGAATGGCCAAAGTTATACTTACTAT
GATTTAAAAGCTGTAGAAGAGCAAGGTATTACTAAAGTTTCCAATTTACCTTATTCAATTCGTGTTTTGT
TAGAATCTTTACTTCGTCAAGAAGATGATTTTGTAATTACAGACGATCATATTAAAGCTTTAAGTCAGTT
TGGAAAAGATGGAAATGAAGGCGAGGTACCATTTAAACCTTCTCGTGTTATTTTACAAGATTTCACAGGT
GTACCAGCCGTAGTTGATTTAGCTTCTTTACGTAAAGCAATGGATGACGTTGGGGGAGATATTACTAAAA
TTAATCCAGAAGTACCGGTGGATTTAGTTATTGACCACTCAGTTCAAGTGGATAGCTATGCAAATCCAGA
AGCTCTTGAACGTAATATGAAATTAGAATTTGAACGTAACTATGAACGTTATCAGTTTTTAAATTGGGCA
ACGAAAGCATTTGATAATTACAATGCAGTTCCTCCTGCAACTGGAATAGTTCACCAAGTTAACTTAGAAT
ATTTAGCAAGTGTTGTACATGTTCGTGATGTAGATGGTGAAAAAACTGCATTTCCAGATACATTAGTTGG
TACTGATTCACATACAACAATGATAAATGGTATTGGCGTACTAGGATGGGGTGTTGGTGGTATTGAAGCT
GAAGCTGGAATGCTTGGACAACCTTCTTATTTCCCAATTCCAGAGGTTATTGGTGTACGACTAGTAAATT
CATTACCACAAGGCGCAACAGCAACTGATTTAGCGTTAAGAGTAACTCAAGAGCTACGTAAAAAAGGTGT
TGTTGGTAAATTTGTGGAGTTCTTTGGTCCAGGTGTACAACATTTACCACTAGCAGACCGTGCTACAATT
GCAAACATGGCACCAGAGTATGGAGCAACTTGCGGATTCTTCCCAGTTGATGATGAATCTCTTAAATATA
TGAAGTTAACTGGTAGATCAGACGAACATATCGCGCTAGTAAAAGAATATTTGAAACAAAACCATATGTT
CTTTGATGTTGAGAAAGAAGATCCTAATTATACAGATGTTATCGAATTGGATTTATCAACAGTTGAAGCA
TCGCTTTCAGGACCAAAACGTCCTCAAGATTTAATTTTCTTAAGTGATATGAAATCATCATTTGAAAATT
CTGTAACAGCTCCAGCAGGCAACCAAGGACACGGTTTAGATAAAAGTGAATTTGATAAGAAAGCTGAAAT
TAACTTTAAAGATGGATCAAAAGCTACAATGAAAACAGGTGATATTGCAATAGCAGCAATTACATCATGT
ACAAATACATCTAACCCTTATGTAATGTTAGGTGCAGGTTTAGTTGCTAAAAAAGCAGTTGAAAAAGGCT
TGAAAGTTCCTGAATACGTTAAAACTTCTCTAGCACCAGGATCAAAAGTTGTTACCGGATATTTAAGAGA
TGCTGGCTTACAACCTTATTTAGATGATTTAGGCTTCAACTTGGTTGGTTATGGATGTACAACTTGTATC
GGTAATTCAGGTCCTTTATTACCAGAAATTGAAAAAGCGATTGCTGATGAGGACCTATTAGTGACATCTG
TATTATCTGGTAACCGTAACTTTGAAGGTCGTATCCATCCTCTTGTTAAAGCCAATTACCTAGCTTCACC
ACAGTTAGTTGTTGCTTATGCATTAGCTGGAACGGTTGATATTGATTTACAGAATGAACCTATTGGTAAA
GGTAATGACGGTGAAGATGTATATTTGAAAGATATTTGGCCATCAATTAAAGAAGTTTCAGATACCGTTG
ATAGTGTTGTAACACCTGAATTATTTATTGAAGAATATAATAACGTATACAATAACAACGAATTATGGAA
TGAGATTGATGTAACTGATCAACCTCTATATGACTTTGATCCTAATTCAACATACATTCAAAATCCATCA
TTCTTCCAAGGATTATCTAAAGAACCGGGTACGATTGTTCCATTAAATGGTTTACGTGTTATGGGTAAAT
TCGGTGATTCTGTGACAACTGACCACATCTCTCCAGCAGGTGCAATTGGTAAAGATACGCCAGCTGGTAA
ATATTTACAAGATCATCAAGTGCCTATTCGTGAATTTAATTCATATGGTTCAAGACGTGGTAATCACGAA
GTAATGGTTCGAGGTACGTTTGCTAATATACGTATTAAAAACCAATTAGCGCCAGGTACTGAAGGTGGTT
TTACAACTTATTGGCCAACAAATGAAGTAATGCCTATCTTTGATGCTGCAATGAAATATAAAGAAGATGG
TACAGGTTTAGTTGTATTAGCTGGTAACGATTATGGTATGGGTTCATCTCGTGACTGGGCAGCAAAAGGT
ACAAACTTATTAGGTGTTAAAACAGTTATTGCACAAAGTTATGAACGTATCCATCGTTCAAATTTAGTTA
TGATGGGTGTATTACCATTAGAGTTTAAAAAAGGTGAATCAGCTGATTCTCTTGGTCTAGATGGTACAGA
AGAAATTTCTGTTAATATTGATGAAAATGTTCAACCACATGACTACGTCAAAGTTACTGCTAAGAAGCAA
GATGGTGATTTGGTAGAATTTGACGCTATGGTTCGTTTTGACTCACTTGTTGAAATGGATTACTATCGTC
ACGGTGGAATTTTACAAATGGTTTTAAGAAATAAATTAGCGCAATA
Protein Sequence 
>gi|15926930|ref|NP_374463.1| aconitate hydratase [Staphylococcus aureus subsp. aureus N315] MAANFKEQSKKHFDLNGQSYTYYDLKAVEEQGITKVSNLPYSIRVLLESLLRQEDDFVITDDHIKALSQFGKDGNEGEVPFKPSRVILQDFTGVPAVVDLASLRKAMDDVGGDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYNAVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPGVQHLPLADRATIANMAPEYGATCGFFPVDDESLKYMKLTGRSDEHIALVKEYLKQNHMFFDVEKEDPNYTDVIELDLSTVEASLSGPKRPQDLIFLSDMKSSFENSVTAPAGNQGHGLDKSEFDKKAEINFKDGSKATMKTGDIAIAAITSCTNTSNPYVMLGAGLVAKKAVEKGLKVPEYVKTSLAPGSKVVTGYLRDAGLQPYLDDLGFNLVGYGCTTCIGNSGPLLPEIEKAIADEDLLVTSVLSGNRNFEGRIHPLVKANYLASPQLVVAYALAGTVDIDLQNEPIGKGNDGEDVYLKDIWPSIKEVSDTVDSVVTPELFIEEYNNVYNNNELWNEIDVTDQPLYDFDPNSTYIQNPSFFQGLSKEPGTIVPLNGLRVMGKFGDSVTTDHISPAGAIGKDTPAGKYLQDHQVPIREFNSYGSRRGNHEVMVRGTFANIRIKNQLAPGTEGGFTTYWPTNEVMPIFDAAMKYKEDGTGLVVLAGNDYGMGSSRDWAAKGTNLLGVKTVIAQSYERIHRSNLVMMGVLPLEFKKGESADSLGLDGTEEISVNIDENVQPHDYVKVTAKKQDGDLVEFDAMVRFDSLVEMDYYRHGGILQMVLRNKLAQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in murine model (Mei et al., 1997).
COG COG1048C, under C: Energy production and conversion
References
Mei et al., 1997: Mei JM, Nourbakhsh F, Ford CW, Holden DW. Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis. Molecular microbiology. 1997; 26(2); 399-407. [PubMed: 9383163].