| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
EhCP5 |
Entamoeba histolytica |
|
|
114796864
|
|
|
|
cysteine proteinase 5 |
Virulence factor |
MUTATION: Parasites with antisense inhibition of EhCP5 were unable to disrupt LS 174T or HT-29F Cl.16 cell monolayers [Ref7038:Moncada et al., 2006].
|
16530514
|
|
|
RabA |
Entamoeba histolytica |
|
2623646
|
2623647
|
|
|
AAB86482.1 |
rab-like GTP-binding protein |
Virulence factor |
MUTATION: EhRabA mutant has reduced adhesion and host cell lysis of CHO monolayers [Ref7039:Welter et al., 2005].
|
15760656
|
|
|
kerp1 |
Entamoeba histolytica HM-1:IMSS |
3407934
|
|
67476017
|
EHI_098210 |
DS571169 |
XP_653629 |
|
Virulence factor |
MUTATION: parasites with blocked expression of kerp1 are attenuated in causing liver abscesses in hamsters [Ref7040:Santi-Rocca et al., 2008].
|
17711481
|
|
|
ehap-a |
Entamoeba histolytica HM-1:IMSS |
3410347
|
|
67481359
|
EHI_118270 |
DS571183 |
XP_656029 |
|
Virulence factor |
MUTATION: Ehap-a gene was silenced resulting in a nonvirulent phenotype in hamsters [Ref7041:Mirelman et al., 2008].
|
18493998
|
|
|
CP5 |
|
|
|
114796866
|
|
|
|
cysteine proteinase 5 |
Virulence factor |
transfection and overexpression of ehcp5 was able to compensate the reduction of in vivo pathogenicity in parasites, which have been silenced for the gene encoding the pore-forming protein amoebapore A. In summary, these results further support the important role of EhCP5 in E. histolytica pathogenicity.[Ref7578:Tillack et al., 2006]
|
16753229
|
|
|
EHI_118270 |
Entamoeba histolytica HM-1:IMSS |
3410347
|
|
67481359
|
EHI_118270 |
DS571183 |
XP_656029 |
|
Virulence factor |
Transfectants of virulent E. histolytica strain HM-1:IMSS, in which the expression of amoebapore was inhibited by approximately 60%, were significantly less pathogenic.
[Ref7615:Bracha et al., 1999] |
10564488
|
|
|
URE3-BP |
|
|
|
10505244
|
|
|
|
URE3-BP sequence specific DNA binding protein |
Virulence factor |
Amebae induced to express a dominant positive mutant form of URE3-BP had an increase in an elongated morphology (30% +/- 6% versus 14% +/- 5%; P = 0.001), a 2-fold competitive advantage at invading the intestinal epithelium (P = 0.017), and a 3-fold increase in liver abscess size (0.1 +/- 0.1 g versus 0.036 +/- 0.1 g; P = 0.03). These results support a role for URE3-BP in virulence regulation.[Ref7579:Gilchrist et al., 2010]
|
20689746
|
|
|
EHI_188210 |
Entamoeba histolytica HM-1:IMSS |
3408004
|
|
67476172
|
EHI_188210 |
DS571206 |
XP_653689 |
|
Virulence factor |
we have confirmed that two genes that are upregulated by ROS confer increased resistance to oxidative stress and have identified an unexpected role of EhSIAF and EhPTPA in host cell adherence and a role of EhSIAF in parasite virulence.[Ref7580:Rastew et al., 2012]
|
23009748
|
|
|
EHI_056680 |
Entamoeba histolytica HM-1:IMSS |
3403382
|
|
67465868
|
EHI_056680 |
DS571423 |
XP_649092 |
|
Virulence factor |
we have confirmed that two genes that are upregulated by ROS confer increased resistance to oxidative stress and have identified an unexpected role of EhSIAF and EhPTPA in host cell adherence and a role of EhSIAF in parasite virulence.[Ref7580:Rastew et al., 2012]
|
23009748
|
|
|
DPD |
Entamoeba histolytica HM-1:IMSS |
3410647
|
|
183231113
|
EHI_012980 |
DS571168 |
XP_656317 |
|
Virulence factor |
dihydropyrimidine dehydrogenase (DPD) is crucial for the parasites growth when the availability of glucose is limited. These data contribute to our understanding of the parasites ability to survive in glucose-poor environments and reveal a new role for the DPD enzyme.
[Ref7581:Baumel-Alterzon et al., 2013] |
23016994
|
|
|
EHI_108720 |
Entamoeba histolytica HM-1:IMSS |
3405630
|
|
67470724
|
EHI_108720 |
DS571346 |
XP_651325 |
|
Virulence factor |
EHI_108720, or HRM-binding protein, represents a new stress-responsive transcription factor in E. histolytica that controls a transcriptional regulatory network associated with oxidative stress. Overexpression of EHI_108720 increased parasite virulence.[Ref7582:Pearson et al., 2013]
|
23250742
|
|
|
rabB |
|
|
|
7144601
|
|
|
|
RabB |
Virulence factor |
we over expressed the wild type EhrabB gene and a mutant gene encoding for a protein (RabBN118I) unable to bind guanine nucleotides and therefore constitutively inactive. The over expression of the mutated protein in E. histolytica trophozoites provoked a dominant negative effect, reflected in a significant decrease of both phagocytosis and cytopathic effect as well as in a failure to produce hepatic abscesses in hamsters. These results confirm that EhRabB is involved in phagocytosis and virulence of E. histolytica.[Ref7583:Juárez-Hernández et al., 2013]
|
23268174
|
|
|
EhCP112 |
Entamoeba histolytica HM-1:IMSS |
6220496
|
|
183236363
|
EHI_010850 |
DS571817 |
XP_001914429 |
|
Virulence factor |
EhCP112 silencing produces a significant reduction in cytolysis and phagocytosis of target cells, indicating the participation of this proteinase in these events. EhCP112 is involved in the in vitro virulence of E. histolytica.[Ref7584:Ocádiz-Ruiz et al., 2013]
|
23981435
|
|
|
igl1 |
|
|
|
15216659
|
|
|
|
Gal/GalNAc lectin Igl1 |
Virulence factor |
Dominant-negative mutations in the Gal/GalNAc lectin affect adhesion and cytolysis. [Ref7618:Gilchrist and Petri, 1999] |
10458982
|
