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DPD

Victor ID 5182
Gene Name DPD
Sequence Strain (Species/Organism) Entamoeba histolytica HM-1:IMSS
NCBI Gene ID 3410647
NCBI Protein GI 183231113
Locus Tag EHI_012980
Genbank Accession DS571168
Protein Accession XP_656317
Taxonomy ID 294381
Gene Starting Position 22532
Gene Ending Position 25237
Gene Strand (Orientation) -
Protein pI 6.53
Protein Weight 91736.53
Protein Length 901
Protein Note transcript EHI_012980A
DNA Sequence 
>gi|183231143:22532-25237 Entamoeba histolytica HM-1:IMSS scf_1104750516425, whole genome shotgun sequence
TTTAGAAAGCTGTTGGAACTTTCTTAAGTTCTTCAGGTGTCATTTCATTCAAACCTTTAACTTTCACATA
TTCTATAGCATTAACTGGACATACTGATGAACAAAGAGCACATCCAATACATTTCTCATCATCGACACGA
TATCTGTTTCCATCCTTAACAATAGCAGTAGTTGAGTTATCACGACAAGATAAAGCACATGAACCGCATC
CAATACAATTATTTTTAATGTGAGCATTTACTCTCCATTTTTCTGGTCCTTCAAGGATCTTTCTTTCTCC
AATATGTTTCAAAGCAATACCAGTAACTTCAGCCAATTTTGGAACTGGTTTATCTTGTTTATTATCAAGA
GTCCAGAATGGTGTCTTTTCTCCATATGGCATAAAGCTTTCAACTCCTTGACTATTAAGATAACCTCTAA
GGTCTGGTCTTGACCAGCAGTATAAAATGAATTTAGTTCCTGAAATAATTTCATCAACAATATCATAACT
CCATTTTTGGACTGAAGAACACATTTGAACTACTGAAGCACCTGTATAAATTAATTGCATAGCAGTTTCA
GCAGATCTAACTCCTCCAATTCCAAGAAGATGACCTCTAACATTTTCATTATGGCGTAATACTTGAGCAA
TTTGTCTAATAGCAATTGGTCTAACAAGATCACCAGAAAGTCCACCAGAAATAGTATTTCTTTCAACACC
AACTTGTGGCCATGGATGACCAGAAAGTGTAATTTCAGAGATACCAAAGACAGTATTAATTGTTGAAACT
CCAGAAGCTCCTCCTCTCATAGCAGCTGCAGCAAGTTCTTCAATATTACCAACGTTTGGAGTAAGTTTTG
GATAAACTGGAATATGAACTGATTCAACTACATATCTTGTACATCTTTCAATAGCAGCTGGTGAAACACC
AATTGCCATTGCCATAGCATTATGAGACTTAAATCCACCTTCACATCCACCTTCATTTCCATCATTACCA
TGACATTCATTTGGACATGAGAAATTCAATTCAAGAGCATCAGCACCAGCTTCTTCAGAAAGTTTAGCAA
GAAGATGCCAATCATCTGCATTATCCATACACATAATTGAAGCAATAACAACTTTATTAGGGAATTCAGC
CTTTAATTTTTTAATTGATTCAAGCCAATAATGATGAGAATGTTCAGAAATCATAACAATATTATTATAT
GAAGTAGACTCTTGTGAATCATAAACTTTAACAATTCTGATATGATTATTCTTTTGTATATCTTTTTCTA
ATGGATATGTTTTAGTAAGAGCAAATCCAAAACCAGCTTGGAAACATCTCTTTAAATGATCATATGTACC
TGAAACTGGAGCAGATGAAATACCAAATGGATTTTCATATTTAATTCCATCAACAGTAACTGAAATATCA
ACGTCATCAACTGGAGTATGGAATTTAGGAATCTTATTAACTCCAAATTCTTTAGCAATAGAAGCAACAA
CAACTTCAGCATCATGAACAGCTTCAACAATTGAGAATGATCTTCTATAATCACCTCCAACATAAACTGC
TCCAAGTCCATTTTCAGCTTTCATAACAAGTCCATTAGCATCTGGAGTTCCTTCAACAAATGAAGCATCT
GGTCCAAAACCAAAAGCACAAATAACTATATCAGCTGGAATAAGTCTTTCAATTCCATTTGGATCATAAA
GGTCTTTACAAATAACTCCTTTAGCATCAAGTCTTTGTGGAAGAACTTTTGGAATAATTTCAATATTTCT
TTCAATAACTCCAATCATTGATTTTTTATGGCAAGTTGCAGTTTTAATATCTTCTCTCATTACTAATAAA
ACTTGAGAAGCTCCATGTTCTTGTGCAGCTTCACAACAATCAACAGCTACATCACCAGATCCAAGAATAG
CTACAGTCTTTCCTTTAACATCAATAGTATTATCAGACATACCATAAAGGAAATCACGAGCAAGTGGTGC
ATCACCAAAAGTATATGGTTTTTGTCTTCCACATCCAACAAAAACATAATCATATTGTTTTCTAAGACCA
GCAATATCACTAGCACTAACTGATGAATTTAATTTAAATTCAATATTTGGATATGATTTAATCATTTCAA
TTTCAAAATCTAATTCTTCTTTAGCAAGTCTTTGTTCTTGAATTTCTTTTCTTAAGATTCCTCCTAAATA
AGCATTTCTTTCAAAAACTACAATCTTCTTGAAATTACATCTTGCAAAGAATGAAGCTGCAGCAAGTCCT
GCAGGTCCTGCTCCAATAATAGCAACACTCTTTTCAATAACTGGAACATTACCAATAGTTGGCATAATTC
TATATTCTTTAAATCTTTGAAGAGAGAAAGCTTGAATTGCATTAATATCAATAGCACCAGCATGTGTTTT
GGACAAGTTGCATCCAGCTTTACAACATTCTTCAGCACTACAAAGATGTCCACATGAAAGAGCAAGTGGA
TTAGCAGTAAGTGCAACACGAGCAGCTTCATAGAAATTATGTTCTCCAGCAGCATGAACCATTCTTTTAG
CATCTAATTGAGTTGGACAACATCTCATACAATTTGGTTCAGCACAATATAAACATCTTCTAGCTTCATG
TACAATTTCAGATTCACTATATTGTGGTTTGAAAGTTTTGTTATAATCAGTAATTTCTTTTCTTTGAGCA
CGAAGGCAATCTCTGTTTTGAATGTCAACAAGTTCAATATCACACA
Protein Sequence 
>gi|183231113|ref|XP_656317.2| dihydropyrimidine dehydrogenase [Entamoeba histolytica HM-1:IMSS]
MCDIELVDIQNRDCLRAQRKEITDYNKTFKPQYSESEIVHEARRCLYCAEPNCMRCCPTQLDAKRMVHAA
GEHNFYEAARVALTANPLALSCGHLCSAEECCKAGCNLSKTHAGAIDINAIQAFSLQRFKEYRIMPTIGN
VPVIEKSVAIIGAGPAGLAAASFFARCNFKKIVVFERNAYLGGILRKEIQEQRLAKEELDFEIEMIKSYP
NIEFKLNSSVSASDIAGLRKQYDYVFVGCGRQKPYTFGDAPLARDFLYGMSDNTIDVKGKTVAILGSGDV
AVDCCEAAQEHGASQVLLVMREDIKTATCHKKSMIGVIERNIEIIPKVLPQRLDAKGVICKDLYDPNGIE
RLIPADIVICAFGFGPDASFVEGTPDANGLVMKAENGLGAVYVGGDYRRSFSIVEAVHDAEVVVASIAKE
FGVNKIPKFHTPVDDVDISVTVDGIKYENPFGISSAPVSGTYDHLKRCFQAGFGFALTKTYPLEKDIQKN
NHIRIVKVYDSQESTSYNNIVMISEHSHHYWLESIKKLKAEFPNKVVIASIMCMDNADDWHLLAKLSEEA
GADALELNFSCPNECHGNDGNEGGCEGGFKSHNAMAMAIGVSPAAIERCTRYVVESVHIPVYPKLTPNVG
NIEELAAAAMRGGASGVSTINTVFGISEITLSGHPWPQVGVERNTISGGLSGDLVRPIAIRQIAQVLRHN
ENVRGHLLGIGGVRSAETAMQLIYTGASVVQMCSSVQKWSYDIVDEIISGTKFILYCWSRPDLRGYLNSQ
GVESFMPYGEKTPFWTLDNKQDKPVPKLAEVTGIALKHIGERKILEGPEKWRVNAHIKNNCIGCGSCALS
CRDNSTTAIVKDGNRYRVDDEKCIGCALCSSVCPVNAIEYVKVKGLNEMTPEELKKVPTAF
Molecule Role Virulence factor
Molecule Role Annotation dihydropyrimidine dehydrogenase (DPD) is crucial for the parasites growth when the availability of glucose is limited. These data contribute to our understanding of the parasites ability to survive in glucose-poor environments and reveal a new role for the DPD enzyme.
(Baumel-Alterzon et al., 2013)
References