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EhCP5

Victor ID 4531
Gene Name EhCP5
Sequence Strain (Species/Organism) Entamoeba histolytica
NCBI Protein GI 114796864
Other Database IDs CDD:30292
Taxonomy ID 5759
Gene Strand (Orientation) ?
Protein Name cysteine proteinase 5
Protein Length 284
Protein Note Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences...; cd02248
Protein Sequence 
>gi|114796864|gb|ABI79444.1| cysteine proteinase 5 [Entamoeba histolytica]
NTWVANNNKHFTIVETLRRRAIFNNNARFIAKFNKNNSFQLSVEGPFAAMTEAEYNSMLKPFVIDKQLEE
IVYDSRGDVPESVDWRAKGKVPAIRDQASCGSCYSFASVAAIEGRLLVAGSKKFTVDDLDLSEQQLVDCS
VSVGNKGCNGGSLLLSFRYVKLNGIMQEKDYPYVAAEETCTYDKKKVAVKITGQKLVRPGSEKALMRAAA
EGPVVAAIDASGVKFQLYKSGIYNSKECSSTQLNHGVAVVGYGTQNGTEYWIVRNSCGTIWGDQGYVLMS
RNKN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Parasites with antisense inhibition of EhCP5 were unable to disrupt LS 174T or HT-29F Cl.16 cell monolayers (Moncada et al., 2006).
References
Moncada et al., 2006: Moncada D, Keller K, Ankri S, Mirelman D, Chadee K. Antisense inhibition of Entamoeba histolytica cysteine proteases inhibits colonic mucus degradation. Gastroenterology. 2006; 130(3); 721-730. [PubMed: 16530514].