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rabB

Victor ID 5184
Gene Name rabB
NCBI Protein GI 7144601
Other Database IDs CDD:215587
CDD:206640
Taxonomy ID 5759
Gene Strand (Orientation) ?
Protein Name RabB
Protein Length 192
Protein Note Rab family protein; Provisional
Protein Sequence 
>gi|7144601|gb|AAF37308.1| RabB [Entamoeba histolytica]
MGDVSSLKILLIGDSGVGKTALLRQYCDQKFSEDVSSTIGVDYRTKRVTFGDKTITLQLWDTAGQERFRN
ITTSYYRGSQGILIVYDVSNFDSLKQVTYWIGELKKENVDGIIFLVGNKIDVTNSLTKEHEDIIKTIDLP
HFTVSAKTGEGVQDLFTQLVKSILEKGLVPEPVGNMEEVSLEKEPTESKGCC
Molecule Role Virulence factor
Molecule Role Annotation we over expressed the wild type EhrabB gene and a mutant gene encoding for a protein (RabBN118I) unable to bind guanine nucleotides and therefore constitutively inactive. The over expression of the mutated protein in E. histolytica trophozoites provoked a dominant negative effect, reflected in a significant decrease of both phagocytosis and cytopathic effect as well as in a failure to produce hepatic abscesses in hamsters. These results confirm that EhRabB is involved in phagocytosis and virulence of E. histolytica.(Juárez-Hernández et al., 2013)
References