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URE3-BP

Victor ID 5179
Gene Name URE3-BP
NCBI Protein GI 10505244
Other Database IDs CDD:238008
CDD:257819
Taxonomy ID 5759
Gene Strand (Orientation) ?
Protein Name URE3-BP sequence specific DNA binding protein
Protein Length 220
Protein Note EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Protein Sequence 
>gi|10505244|gb|AAG18423.1|AF291721_1 URE3-BP sequence specific DNA binding protein [Entamoeba histolytica]
MQPPVANFCLWNLQPIQGSWMGAACIYQMPPSVRNTWWFPLLNTIPLDQYTRIYQWFMGVDRDRSGTLEI
NELMMGQFPGGIRLSPQTALRMMRIFDTDFNGHISFYEFMAMYKFMELAYNLFVMNDRNRSGTLEPHEIL
PALQQLGFYINQRTSLLLHRLFARGMAFCDLNCWIAICAFAAQTRSAYQMIFMNPYYGPMKPFNPMEFGK
FLDVVTSLLE
Molecule Role Virulence factor
Molecule Role Annotation Amebae induced to express a dominant positive mutant form of URE3-BP had an increase in an elongated morphology (30% +/- 6% versus 14% +/- 5%; P = 0.001), a 2-fold competitive advantage at invading the intestinal epithelium (P = 0.017), and a 3-fold increase in liver abscess size (0.1 +/- 0.1 g versus 0.036 +/- 0.1 g; P = 0.03). These results support a role for URE3-BP in virulence regulation.(Gilchrist et al., 2010)
References