| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
TS |
Trypanosoma cruzi strain CL Brener |
3533424
|
|
71402314
|
Tc00.1047053504593.1 |
AAHK01002618 |
XP_804086 |
|
Virulence factor |
MUTATION: T. cruzi isolates that express and shed higher amounts of trans-sialidase are more virulent in mice [Ref6999:Risso et al., 2004].
|
15181573
|
|
|
Tc52 |
|
|
|
32395938
|
|
|
|
thiol transferase Tc52 |
Virulence factor |
MUTATION: Tc52 mutant is attenuated in mice [Ref7000:Garzón et al., 2003].
|
12946866
|
|
|
LYT1 |
|
|
|
343407444
|
|
|
|
LYT1 |
Virulence factor |
the deletion of both LYT1 alleles in the CL Brenner strain (the wild type [WT]) resulted in a null mutant T. cruzi clone (L16) that shows an attenuated phenotype in cell culture models. The infection of adult Swiss mice with 10(3) trypomastigotes of both clones revealed a significant reduction in infective behavior of L16, as shown by direct parasitemia, spleen index, and quantitation of tissue parasite burden, suggesting the loss of virulence in the null mutant clone.[Ref7001:Zago et al., 2008]
|
17938222
|
|
|
p85.1 |
Symbiobacterium thermophilum IAM 14863 |
2981057
|
|
51893741
|
STH2603 |
AP006840 |
YP_076432 |
hypothetical protein |
Virulence factor |
p85.1 is expressed as mRNA and the corresponding protein is found on the surface of virulent Trypanosoma cruzi but not attenuated ones. virulent parasites not only gained the ability to cause high parasitemia but also caused higher mortality rates than the attenuated parasites. |
|
|
|
DHFR-TS |
|
|
|
1899001
|
|
|
|
dihydrofolate reductase-thymidylate synthase |
Virulence factor |
The dhfr-ts(+/-) mutant is possible to generate genetically attenuated T. cruzi parasites able to confer protection against further T. cruzi infections.
[Ref7576:Perez et al., 2011][Ref7577:Pérez and BasombrÃo, 2012] |
22180798
22705838
|
|
|
Tc-CRT |
Trypanosoma cruzi strain CL Brener |
3543786
|
|
71423784
|
|
AAHK01000598 |
XP_812571 |
|
Virulence factor |
deletion of one copy of the TcCRT gene in the attenuated TCC strain generated a safe and irreversibly gene-deleted live attenuated parasite with high immunoprotective properties. Our results also contribute to endorse the important role of TcCRT as a T. cruzi virulence factor.
[Ref7614:Sánchez-Valdéz et al., 2014] |
24551259
|
|
|
PLA1 |
|
|
|
372001299
|
|
|
|
phospholipase A1 |
Virulence factor |
T. cruzi PLA1 as a novel virulence factor implicated in parasite invasion.
[Ref7613:Belaunzarán et al., 2013] |
23275096
|
|
|
trans-sialidase |
Trypanosoma cruzi strain CL Brener |
3537653
|
|
71410253
|
|
AAHK01001396 |
XP_807431 |
|
Virulence factor |
The trans-sialidase (TS) is a virulence factor involved in cell invasion and pathogenesis that is differentially expressed in aggressive and less virulent parasite stocks.
[Ref7617:Burgos et al., 2013] |
23536842
|
