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DHFR-TS

Victor ID 5176
Gene Name DHFR-TS
NCBI Protein GI 1899001
Other Database IDs CDD:240299
CDD:238127
CDD:238211
Taxonomy ID 5693
Gene Strand (Orientation) ?
Protein Name dihydrofolate reductase-thymidylate synthase
Protein Length 521
Protein Note bifunctional dihydrofolate reductase-thymidylate synthase; Provisional
Protein Sequence 
>gi|1899001|gb|AAB49898.1| dihydrofolate reductase-thymidylate synthase [Trypanosoma cruzi]
MSLFKIRMPETVAEGTRLALRAFSLVVAVDEHGGIGDGRSIPWNVPEDMKFFRDLTTKLRGKNVKPSPAK
RNAVVMGRKTWDSIPPKFRPLPGRLNVVLSSTLTTQHLLDGLPDEEKRNLHADSIVAVNGGLEQALRLLA
SPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFRVPESGTEAAAGIEWQRET
ISEELTSANGNETKYYFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLP
LLTTKRVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHF
GAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVSNGELSCML
YQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFR
REREFLEDYEEGDMEVIDYAPYPPISMKMAV
Molecule Role Virulence factor
Molecule Role Annotation The dhfr-ts(+/-) mutant is possible to generate genetically attenuated T. cruzi parasites able to confer protection against further T. cruzi infections.
(Perez et al., 2011; Pérez and Basombrío, 2012)
References