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LYT1

Victor ID 4463
Gene Name LYT1
NCBI Protein GI 343407444
Other Database IDs CDD:236798
Taxonomy ID 5693
Gene Strand (Orientation) ?
Protein Name LYT1
Protein Length 550
Protein Note putative mechanosensitive channel protein; Provisional
Protein Sequence 
>gi|343407444|gb|AEM23729.1| LYT1, partial [Trypanosoma cruzi]
KKAAALVAPTADSRPTCRGAAIANNFMERAGPREGVGRSTEMPAAGPTGSQRSQTQREVKASQDADAAAI
SSYFQSELETSQSHEGVSPLAKTRANERRNGEQEREKELPAAGGAVPTRKGTDPKKRVLQDLPAMHAEGQ
NQHGREGDKGVSVGMDSPGRIQVLEQMLLHLAALNRQLELELIETRRELTMYKQLLPDVQRQTEAHALSQ
EHHKANSAAPPLMSDERRRQMLFTGQQQQQQQAEDLHGGISGWETAARRMRYGYGEGERDTLSDGEGRPR
CAGRMGSPKRFLSTQPPRSSRNYRNPHAANGTNGNSYVPHLSRQKGHPKRGAAVNSVPLAASATNRRGRS
VRQHTRPRGPSHLFEHLDAEDAIDMLETLKRSLMYRCNHSHHRSTEGDVVRPATKSRKGTRSVPPPPPPP
PMSSSSQRRLAAAVAGAPVCSVSGRHGRNHGVSAAGDPSRGDRVSETAHIAHAPSFGGKNCAPGPTQLHF
SSPSRRATPMKKDTPLSRGQAAGVAAVAEGGDGQLEALQRRYWEQSRAILEQLENMLAAD
Molecule Role Virulence factor
Molecule Role Annotation the deletion of both LYT1 alleles in the CL Brenner strain (the wild type [WT]) resulted in a null mutant T. cruzi clone (L16) that shows an attenuated phenotype in cell culture models. The infection of adult Swiss mice with 10(3) trypomastigotes of both clones revealed a significant reduction in infective behavior of L16, as shown by direct parasitemia, spleen index, and quantitation of tissue parasite burden, suggesting the loss of virulence in the null mutant clone.(Zago et al., 2008)
References
Zago et al., 2008: Zago MP, Barrio AB, Cardozo RM, Duffy T, Schijman AG, Basombrío MA. Impairment of infectivity and immunoprotective effect of a LYT1 null mutant of Trypanosoma cruzi. Infection and immunity. 2008; 76(1); 443-451. [PubMed: 17938222].