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Tc-CRT

Victor ID 5200
Gene Name Tc-CRT
Sequence Strain (Species/Organism) Trypanosoma cruzi strain CL Brener
NCBI Gene ID 3543786
NCBI Protein GI 71423784
Genbank Accession AAHK01000598
Protein Accession XP_812571
Taxonomy ID 353153
Gene Starting Position 14778
Gene Ending Position 15983
Gene Strand (Orientation) +
Protein pI 4.5
Protein Weight 44325.45
Protein Length 401
DNA Sequence 
>gi|164450877:14778-15983 Trypanosoma cruzi strain CL Brener 1047053517121 genomic scaffold, whole genome shotgun sequence
GATGCGTGCAGCGATTTTTTTCTGTGCCCTTTTGAGCCTTGCGACACTGTCAGCCGTGCACGGCACGGTG
TACTTCCACGAGGAGTTTAAGAGCATGGAACACTGGACTACCTCAAAGCACCGCGATGACTTTGGAAAGG
TGGAGATTTCAGCGGGTAAATTTTACGCGGATGCGGAGAAGAGCAAAGGTCTCCGTCTGACGGAGGATGC
GCGGTTTTACGCCTTGTCTACTGCCTTCCCAACGCCTATCACCAATGAAAAGAAAAGCCTTGTTGTCTCC
TTCTCCGTGAAGCACGAGCAGGATCTGAAGTGCGGCGGCGGCTACATCAAGCTGCTCCCCTCGATGGATC
CCGAGAAGTTTCACGGTGAAACGAAGTACTGGCTGATGTTTGGCCCGGACCGCTGTGGCTCACAGAACCG
AGTGCACATCATCCTGCACTATAACGGGGAGAACCGCGAGTGGTCAAAGAGAATACGCTTCCCTGAGGAT
AAACTCACGCACGTGTACACGTTGCACATTGCCGCCGACAACTCCTACGAGTTTTTTCTGGACGGCGAGT
CGAAGGCGAAGGGCCAGCTCGACGGTGACTGGACTCTGCTGCCGCCACGCGAGATTGTCGACGAGACGGA
CAAGAAACCAGAGGACTGGGTGGACGAGGAGACGATGGATGACCCGGAGGACAAGAAGCCGGAGGACTGG
GACAACGAACCCGCAATGATCCCGGACGCGGATGCGAAAAAGCCCGATGACTGGGACGATGCGGAGGACG
GTCCGTGGGAGGCTCCGATGATCCCGAACCCGAAGTCGAAGGGCACATGGAAGCCACGTCAGATTCCCAA
CCCGGCGTACAAGGGCGTGTGGGAGCCGCGGAAGATTCCTAATCCAGACTTTGTTGAGGACTCTGAGCTC
CACAAGGTTCCGGAGCCGCTCACACACGTTGGCATTGACGTCTGGCAGGTCGAATCCGGCAGCATTTTTA
AGGACATTATGATTGGCGATGACTTGAAGGAGGTGTTGGAATTGGTGGAGAAGACATATGGCAGCCTGAA
GAAAGCGGAGGCGGATGCTCTTAAGGTCATGGAGGATATGGAGAAGGAGAAGAGGAAGAAGGAGGAAGAG
GAGGAGAAGGAGAAGGAAAAGGCGGAAGAAGAAAAGGATGAAGAAGAGTTGGAAGAAAAGGGTGACGGTG
ATAAGGAGGATTTGTA
Protein Sequence 
>gi|71423784|ref|XP_812571.1| calreticulin [Trypanosoma cruzi strain CL Brener]
MRAAIFFCALLSLATLSAVHGTVYFHEEFKSMEHWTTSKHRDDFGKVEISAGKFYADAEKSKGLRLTEDA
RFYALSTAFPTPITNEKKSLVVSFSVKHEQDLKCGGGYIKLLPSMDPEKFHGETKYWLMFGPDRCGSQNR
VHIILHYNGENREWSKRIRFPEDKLTHVYTLHIAADNSYEFFLDGESKAKGQLDGDWTLLPPREIVDETD
KKPEDWVDEETMDDPEDKKPEDWDNEPAMIPDADAKKPDDWDDAEDGPWEAPMIPNPKSKGTWKPRQIPN
PAYKGVWEPRKIPNPDFVEDSELHKVPEPLTHVGIDVWQVESGSIFKDIMIGDDLKEVLELVEKTYGSLK
KAEADALKVMEDMEKEKRKKEEEEEKEKEKAEEEKDEEELEEKGDGDKEDL
Molecule Role Virulence factor
Molecule Role Annotation deletion of one copy of the TcCRT gene in the attenuated TCC strain generated a safe and irreversibly gene-deleted live attenuated parasite with high immunoprotective properties. Our results also contribute to endorse the important role of TcCRT as a T. cruzi virulence factor.
(Sánchez-Valdéz et al., 2014)
References