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Tc52

Victor ID 4462
Gene Name Tc52
NCBI Protein GI 32395938
Other Database IDs CDD:48493
CDD:48103
CDD:185959
Taxonomy ID 5693
Gene Strand (Orientation) ?
Protein Name thiol transferase Tc52
Protein Length 415
Protein Note Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; cd00570
Protein Sequence 
>gi|32395938|gb|AAO63167.1| thiol transferase Tc52 [Trypanosoma cruzi]
ITAKEKRVTLEEVEVPLGDDMPQWYKELNPRETVPTLQVDGKKCMIESDLISRYIDRISSPXNALXGSSP
YQRHRVEFFLXEIGDLVKAYFGLVRDPFNEEKRKSVDXNTAYIEGIIAEHQGDGPYFLDDTFSMAEVMVV
PFLACFRPVLSYYCGYDIFHDAPRLKKMYVTSMQRTTVKETISKPEEYIIGFKSKVPKSHVTWSLAPGYV
LFVNKYSPFSDRPRLACALKNIDLPMLEIDLKQLPSWFRWFNQRETVPTLLTPQGTYVHESQLIVHYLDD
GFPEHGPALLPKDADGSYHVRFVESNVDYFMDAMYSFIKDPKNMNAKEEFDWAAGELEKLLAEHQFGEGP
FFGGATMNAADVSLVPMLVHLKACTPDLTEGQDLLANYKLLAAAAEAGLTSEAGKKVFLSLSEYS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Tc52 mutant is attenuated in mice (Garzón et al., 2003).
References
Garzón et al., 2003: Garzón E, Borges MC, Cordeiro-da-Silva A, Nacife V, Meirelles Mde N, Guilvard E, Bosseno MF, Guevara AG, Brenière SF, Ouaissi A. Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele elicits attenuated Chagas' disease in mice. Immunology letters. 2003; 89(1); 67-80. [PubMed: 12946866].