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TS

Victor ID 4461
Gene Name TS
Sequence Strain (Species/Organism) Trypanosoma cruzi strain CL Brener
NCBI Gene ID 3533424
NCBI Protein GI 71402314
Locus Tag Tc00.1047053504593.1
Genbank Accession AAHK01002618
Protein Accession XP_804086
Taxonomy ID 353153
Gene Starting Position 2989
Gene Ending Position 5219
Gene Strand (Orientation) -
Protein pI 4.62
Protein Weight 75748.55
Protein Length 742
DNA Sequence 
>gi|71402315:2989-5219 Trypanosoma cruzi strain CL Brener tcruzi_1047053504593, whole genome shotgun sequence
CTCAGCAGAGAGCCGCGGTGCCCCACAGCCCCAGAAGCAGCAGCAACAACACCCGAGACACACACCCATG
CACGGTGCTGTCACCAATTAGAGCCATGGACGCCAAATCGCTCAAATGCCCGTGCTCAAGCAAAATGACA
GGGTCCAAGGGTATTGTGGCGTTGGACTCCGATGGGATCTTGGTTTCCCCAGGCGTTGTGCGCAAATAAT
CCTTTGCGGCATCACCGCCATCCAACACTTCATCATGGCCTTGAGCAGTTGCCGGATCTGTGCTGGGCTC
ATGGGCGGCTGTGGCACCGTCCATGGGCGCCACCTCAGTGCTGTGGGATGAGTCGGGGCCGCTGCTCGCA
CCCACGGCAGTGTGGGGATTTGTGTCCTTCCTCTCCTCGGGTTCAACGGTTTGTTCGTCGCTGGTGAGCG
TGGCGGAATGGGACGACGACTCTTCCATGTCCTCTGAAGCATCAGATAGAGTGCTGTGCTGCGGCCGATC
TTCAGTGGTTTTCCTCTGCGGAGTGGCGACAACCGCCTCTTCAGCCTGCTCCGTCATCGGCCGAACCACG
CTGAGAGACGAGTGCTCCTGTTCACGTTCAAAGTGATCCTCAGTGGCAGGGAAATCGGTTTCAGGTGCTT
TTTGAGGACTGCCTTCTCCCGCTGTTGGAGTCAATGAGGACGCCGAGCCAACACTGCTGGATGCCACTTC
TTCCACTTCCCCCTCGGCGGCTGAGGTGGACGAGCCAGTGAAATCAGCAGAAGTTGTCTGCCCGGAACCT
GCTGAATACTTTTCATTTTTTGATTTTTCCGGTGATAATCCTTGATTTTGTGTTGATGGTGTGGTGTCTT
TTTCAGAAGCTTGTCCCAAATGACTGTTTTGAGGCGCACCTTCCGGGGCCGACACCTCCGCCTCTGAAGC
AGCGACTGCCTTCGTCTTCATTAGTGGGTTGAGCTCATCATCTTGCAATAAGCGGTTGTACAGCAGGACG
TTGCTCACCGTCACATGAATGTTGCCCGAGCTGCTCTTGCCGTCCCCGCCAATGTAAAAGTGCGAGATGC
TGTGGGAGCTCAACAGTTTTCGTAACTTGTGAGAAAAGCTCTTATAGCCCTCGTAATCCTCATCTTCATA
ATCTTCGGTGTCGCATATCCTCTTTCCATTCACGTACACAAACAACCCATCATCACAATCCATTTGCAGT
GCCAAATGGTATTTCTTGTTTGCTTCCCATTCGACATTCTCATAATGCGCCGGCAGCGGCAAGCGACTGC
CGTTGAAGATTATCCTCCACTCTTTGTCGTGGGTGTACGACAGACCAAAAAGCACCGTGCCTTGTGCATC
GTTCATCCTCACACCCATCAAAGGGATGGGGCTGCTGCCTGTCTCCGGAGCCTTATCGATGGACACCGTC
GCCACAAGAGTAAACTTGTCGTTCGCAAAGTGGTACGGCACAGTCTGCCCCATGTCGCCAACAGGCCACT
TCGCCCCTGCTCCGGGTCCTTTGAACGTCAATCCACCATCAGGAGCACTTTCCACTTCCCCGTGAACGGT
TGCATTCACGCAGAGGTACTCGTCACTCCATGTGTTCTTAGTTGACTTGTTGGATAAGAGGCCAACCAGC
CCCTTGGTGAGTTCACGAGCATCACAGCCACTGCGCCAATTATTCTTTTCATTCCCGCAGCGGTACTCCT
TCGCAATTTGCGCGTCCTTTTCCTTCCATGCAGCCAATACCTTCCTCATATCCTCCAACTTCTCCGTCAA
GCCCACAAAAGCAATGTTGTACTTACCGTCCTCTGCAGCGACCTCGTACGAGCAGTACAGTTTCTTCTCT
TCCTTCGGTTCTTCCTCTTTCAATGGCTGCGCTTCGACCGTGGCGTACAGCAGAGTGCTGGCGGCGACGT
TCTCACCCACAGCGGATATCGGCCCAACATCATAAATTCGCTGCATGTCCGTCAGCCACAAGTGAAGTCG
GCCCGTTTCTTTTTTATCCTTCTCAGAATATACCGGCCGACTGACGAGGATGACTTTCTGTCCATCGATC
ATCGCGCTGACGAAGCCACCCTGCGCGCCGTGCCCCACACGTGTACGTGAGTTGCCCCACACGCGTGAAA
GAGTGTCGTATTCCTCCGTCCACAAATTCCCCATGGTGCTTGACCTGTAAACCCTGCGGCTGCCGTCATC
ACACGACGTCATCATTATAAGCTCTTTTTCCTTCCATTCAAGAACCGCAGGCTGGATGCAT
Protein Sequence 
>gi|71402314|ref|XP_804086.1| trans-sialidase [Trypanosoma cruzi strain CL Brener]
CIQPAVLEWKEKELIMMTSCDDGSRRVYRSSTMGNLWTEEYDTLSRVWGNSRTRVGHGAQGGFVSAMIDG
QKVILVSRPVYSEKDKKETGRLHLWLTDMQRIYDVGPISAVGENVAASTLLYATVEAQPLKEEEPKEEKK
LYCSYEVAAEDGKYNIAFVGLTEKLEDMRKVLAAWKEKDAQIAKEYRCGNEKNNWRSGCDARELTKGLVG
LLSNKSTKNTWSDEYLCVNATVHGEVESAPDGGLTFKGPGAGAKWPVGDMGQTVPYHFANDKFTLVATVS
IDKAPETGSSPIPLMGVRMNDAQGTVLFGLSYTHDKEWRIIFNGSRLPLPAHYENVEWEANKKYHLALQM
DCDDGLFVYVNGKRICDTEDYEDEDYEGYKSFSHKLRKLLSSHSISHFYIGGDGKSSSGNIHVTVSNVLL
YNRLLQDDELNPLMKTKAVAASEAEVSAPEGAPQNSHLGQASEKDTTPSTQNQGLSPEKSKNEKYSAGSG
QTTSADFTGSSTSAAEGEVEEVASSSVGSASSLTPTAGEGSPQKAPETDFPATEDHFEREQEHSSLSVVR
PMTEQAEEAVVATPQRKTTEDRPQHSTLSDASEDMEESSSHSATLTSDEQTVEPEERKDTNPHTAVGASS
GPDSSHSTEVAPMDGATAAHEPSTDPATAQGHDEVLDGGDAAKDYLRTTPGETKIPSESNATIPLDPVIL
LEHGHLSDLASMALIGDSTVHGCVSRVLLLLLLGLWGTAALC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: T. cruzi isolates that express and shed higher amounts of trans-sialidase are more virulent in mice (Risso et al., 2004).
References
Risso et al., 2004: Risso MG, Garbarino GB, Mocetti E, Campetella O, Gonzalez Cappa SM, Buscaglia CA, Leguizamon MS. Differential expression of a virulence factor, the trans-sialidase, by the main Trypanosoma cruzi phylogenetic lineages. The Journal of infectious diseases. 2004; 189(12); 2250-2259. [PubMed: 15181573].