|
|
Victors Search
Found 7 gene(s).
Export as Excel file, text file
| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
US8 |
Bovine herpesvirus 1 |
1487407
|
|
9629888
|
BoHV1_gp42 |
AJ004801 |
NP_045372 |
envelope glycoprotein E |
Virulence factor |
MUTATION: Strain A of the virus has a mutation in the glycoprotein E gene, and is avirulent in calves [Ref7324:Kaashoek et al., 1994].
MUTATION: the Za strain of BHV1 is attenuated by a deletion of the gE gene and is used as a live attenuated vaccine [Ref7325:Kaashoek et al., 1995]. |
8023552
7793128
|
|
|
UL23 |
Bovine herpesvirus 1 |
1487380
|
|
9629852
|
BoHV1_gp21 |
Z78205 |
NP_045336 |
thymidine kinase |
Virulence factor |
MUTATION: A thymidine kinase-deficient mutant (B8-D53) showed no detectable thymidine kinase-inducing activity and was attenuated in calves [Ref7371:Kit et al., 1985]. |
2994602
|
|
|
gE |
|
|
195593051
|
195593052
|
|
|
ACG50670.1 |
truncated glycoprotein E |
Virulence factor |
MUTATION: the gE and gE/TK deletion mutants were avirulent [Ref7458:van et al., 1994]. |
8077929
|
|
|
UL47 |
Bovine herpesvirus 1 |
1487395
|
|
9629828
|
BoHV1_gp07 |
M84469 |
NP_045312 |
tegument protein VP13/14 |
Virulence factor |
The U(L)47 deletion mutant exhibited reduced plaque size and more than 100-fold decrease in intracellular and extracellular viral titers in cultured cells. the U(L)47 gene product was indispensable for BHV-1 replication in vivo, since no clinical manifestations or viral shedding were detected in the U(L)47 deletion mutant-infected calves, and the virus failed to induce significant levels of humoral and cellular immunity. [Ref7461:Lobanov et al., 2010] |
19864376
|
|
|
BICP0 |
Bovine herpesvirus 1 |
1487364
|
|
9629879
|
BoHV1_gp35 |
M84465 |
NP_045363 |
ubiquitin E3 ligase ICP0 |
Virulence factor |
During acute infection of calves, levels of infectious virus were 2 to 3 logs lower in ocular or nasal swabs with 51g than with 51gR. Calves latently infected with the 51g mutant did not reactivate from latency because virus shedding did not occur in ocular or nasal cavities. [Ref7462:Saira et al., 2008] |
18842710
|
|
|
US4 |
|
|
291500676
|
291500677
|
|
|
ADE08263.1 |
glycoprotein G |
Virulence factor |
Glycoprotein gC, gG, gI and gE single deletion mutants, a gI/gE double deletion mutant and a gE frame-shift mutant were made. The virulence and immunogenicity of these mutants were evaluated in specific-pathogen-free calves. Except for the gC deletion mutant, all mutants were significantly less virulent than the parental wild-type (wt) BHV1 strain Lam. [Ref7324:Kaashoek et al., 1994] |
8023552
|
|
|
US7 |
|
|
291500678
|
291500679
|
|
|
ADE08264.1 |
glycoprotein I |
Virulence factor |
Glycoprotein gC, gG, gI and gE single deletion mutants, a gI/gE double deletion mutant and a gE frame-shift mutant were made. The virulence and immunogenicity of these mutants were evaluated in specific-pathogen-free calves. Except for the gC deletion mutant, all mutants were significantly less virulent than the parental wild-type (wt) BHV1 strain Lam. [Ref7324:Kaashoek et al., 1994] |
8023552
|
|
