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US4

Victor ID 5057
Gene Name US4
NCBI Nucleotide GI 291500676
NCBI Protein GI 291500677
Protein Accession ADE08263.1
Taxonomy ID 10320
Gene Strand (Orientation) ?
Protein Name glycoprotein G
DNA Sequence 
>gi|291500676|gb|GU591889.1| Bovine herpesvirus 1 strain NM06 glycoprotein G (US4) gene, complete cds
CTTCGGTGCGGCCTCGGGGTAGCCCCGGGGGTTTCCCGCAAAACTGAGGCATATAAGGCGCGGGCACCGG
CAAGTTTGGCATCCACACTTCGCGCTGTGGACACGAGAGCGAACGCGAGCGAACGCGAGCGCAAGCGCGA
GCACACGACTGCGATCATGCCTGCCGCCCGGACCGGCACCTTGGCCGCCGTCGCCCTAATCCTGCTCTGC
GGGGCCGCCGTTTTGGGGCGCCCCGCGCCCGACGACCTCTGTTTCGCCGACGTGCGCCGCACTGGCATGG
CGCCCTCCCGCCCGCTGGGGCCCGTCCTGAACCTAGCGGCCTCGGATTTGACCTCGCGGGTTTCGGTGCG
CGCGGTGGACGCTTCGCGCGGCTGCGCCCTGGCCCTCTTGGACATGGCGGAGACGGTGGTGCCCGGCGGA
CCGCGAGCCGCCGACGTCGTCGACGTCGGCTGGGCTTACCAAGACGGGGACTGCATGGTGCCTCTGGCAT
ATCGCCAGTACTTTAACTGCACGGGGGGCGCGCTGCCCGGCCAAAACGTCTGCGCCGGGCTCTCTGAGAC
CCGCATCCGCGGTGGCTTTGGAACCTCCGACTACGCGCTCTACGGGACGTCGCTAGTACTGCGCACCGGC
CTGTACGACCGCGGGACCTACATCTACTTCCTTGGATACGGCCCAGACGACATCTACGTGGGCAGCGTCA
CGCTCATGGTGGGCGCCGACATCCACAAATACCCCTGCGGGCTGGACCGAGGGCTCGGTGTGGCCCTGCA
CCACAAGAGCGGACCGGCCCGACCTCTGACAGAGGACGACGCCACCGGCGACTGGGCCTGCGGCTGCTTC
CCCGCCCTTGTTGAGGTTGACGCGGTGTGGGGCAACGTAAGCGCCGCAGAGCTGGGCCTGGCCGACCCGA
TCGACTACGCCGACGAAGGGGGCGAGGTCGAAGTGCTCGAGGACGAAGCCGGGAGCGCCAGCGAAAACCT
GCCGCAGGACGACCCCGACCCCGACCTCGCAGATTGCCGGACCGTCGGGCTCTTTAGCGAAAGCGACATG
TTCCGGACCGCCAGCGGGCCCGAATCGCTGCTGATCGGCGCCGTTGCCAAGGACGTCCTGACGGTGCCCC
TCAATCTGCCGCCCGGCCGCTCTTACGAGGCCCTGCGAAACGCATCGCTGGAGTGCAACTCCCGCCCGCG
CGAGACCGGCGACGCAGCGGTGGTGGTGATGTCTCTCCAGGAGCCCGCTCGCCTCGAGCGCCGCCCCGAT
GCCCGCGCCACCGATCCGGAGTTTGGGCTCTTTGGCCTGCCCGATGACCCCGCCGTGCGGCGCGGCATTC
TCATCGGCCTCGCGATCGCTCTGCTGGTGCTGCTGTTTTCGCTGGTGATCGTGCTCGTCTGCGCCTGCCG
GCTCGCCCGCGCAGCCAAGGCTGCGCGACGCGCCCGCGCCGCCACGTTCGCCAAGAGCAACCCCGCGTAC
GAGCCGATGCTCAGCGTCTGATCGCCGGCACCCCACGCCGCCCCGACCCCGCTGTCCCGCGTTTACAATA
AACAGTTATTCTTACCAACGTTGGTGCGCCTGTCGCGTGTCTATTGCGAGTTAAACCGA
Molecule Role Virulence factor
Molecule Role Annotation Glycoprotein gC, gG, gI and gE single deletion mutants, a gI/gE double deletion mutant and a gE frame-shift mutant were made. The virulence and immunogenicity of these mutants were evaluated in specific-pathogen-free calves. Except for the gC deletion mutant, all mutants were significantly less virulent than the parental wild-type (wt) BHV1 strain Lam. (Kaashoek et al., 1994)
References
Kaashoek et al., 1994: Kaashoek MJ, Moerman A, Madić J, Rijsewijk FA, Quak J, Gielkens AL, van Oirschot JT. A conventionally attenuated glycoprotein E-negative strain of bovine herpesvirus type 1 is an efficacious and safe vaccine. Vaccine. 1994; 12(5); 439-444. [PubMed: 8023552].