Protegen ID	Gene Name	Sequence Strain (Species/Organism)	NCBI Gene ID	NCBI Nucleotide GI	NCBI Protein GI	Locus Tag	Genbank Accession	Protein Accession	Protein Name	Protein Annotation	Molecule Role	Molecule Role Annotation	COG	PMID
4893	US8	Bovine herpesvirus 1	1487407		9629888	BoHV1_gp42	AJ004801	NP_045372	envelope glycoprotein E		Virulence factor	MUTATION: Strain A of the virus has a mutation in the glycoprotein E gene, and is avirulent in calves [Ref7324:Kaashoek et al., 1994].; MUTATION: the Za strain of BHV1 is attenuated by a deletion of the gE gene and is used as a live attenuated vaccine [Ref7325:Kaashoek et al., 1995]. 		8023552, 7793128 
4953	UL23	Bovine herpesvirus 1	1487380		9629852	BoHV1_gp21	Z78205	NP_045336	thymidine kinase		Virulence factor	MUTATION: A thymidine kinase-deficient mutant (B8-D53) showed no detectable thymidine kinase-inducing activity and was attenuated in calves [Ref7371:Kit et al., 1985]. 		2994602
5054	gE			195593051	195593052			ACG50670.1	truncated glycoprotein E		Virulence factor	MUTATION: the gE and gE/TK deletion mutants were avirulent [Ref7458:van et al., 1994].		8077929
5055	UL47	Bovine herpesvirus 1	1487395		9629828	BoHV1_gp07	M84469	NP_045312	tegument protein VP13/14		Virulence factor	The U(L)47 deletion mutant exhibited reduced plaque size and more than 100-fold decrease in intracellular and extracellular viral titers in cultured cells. the U(L)47 gene product was indispensable for BHV-1 replication in vivo, since no clinical manifestations or viral shedding were detected in the U(L)47 deletion mutant-infected calves, and the virus failed to induce significant levels of humoral and cellular immunity.  [Ref7461:Lobanov et al., 2010]		19864376
5056	BICP0	Bovine herpesvirus 1	1487364		9629879	BoHV1_gp35	M84465	NP_045363	ubiquitin E3 ligase ICP0		Virulence factor	During acute infection of calves, levels of infectious virus were 2 to 3 logs lower in ocular or nasal swabs with 51g than with 51gR. Calves latently infected with the 51g mutant did not reactivate from latency because virus shedding did not occur in ocular or nasal cavities.  [Ref7462:Saira et al., 2008]		18842710
5057	US4			291500676	291500677			ADE08263.1	glycoprotein G		Virulence factor	Glycoprotein gC, gG, gI and gE single deletion mutants, a gI/gE double deletion mutant and a gE frame-shift mutant were made. The virulence and immunogenicity of these mutants were evaluated in specific-pathogen-free calves. Except for the gC deletion mutant, all mutants were significantly less virulent than the parental wild-type (wt) BHV1 strain Lam. [Ref7324:Kaashoek et al., 1994]		8023552
5058	US7			291500678	291500679			ADE08264.1	glycoprotein I		Virulence factor	Glycoprotein gC, gG, gI and gE single deletion mutants, a gI/gE double deletion mutant and a gE frame-shift mutant were made. The virulence and immunogenicity of these mutants were evaluated in specific-pathogen-free calves. Except for the gC deletion mutant, all mutants were significantly less virulent than the parental wild-type (wt) BHV1 strain Lam. [Ref7324:Kaashoek et al., 1994]		8023552