Victors

UL47
Victor ID	5055
Gene Name	UL47
Sequence Strain (Species/Organism)	Bovine herpesvirus 1
NCBI Gene ID	1487395
NCBI Protein GI	9629828
Locus Tag	BoHV1_gp07
Genbank Accession	M84469
Protein Accession	NP_045312
Taxonomy ID	10320
Gene Starting Position	11962
Gene Ending Position	16598
Gene Strand (Orientation)	+
Protein Name	tegument protein VP13/14
Protein pI	8.7
Protein Weight	76389.76
Protein Length	739
DNA Sequence	>gi\|9629818:11962-16598 Bovine herpesvirus 1, complete genome CATGGACGCCGCTAGGGATGGGCGGCCTGAGCGCCGCCGCGCCGTCTCCGGAACGTACCGCACGCACCCG TTCCAGCGCCCCTCTGCCCGGCGGAGCGCTGGACGCCCTGCGCGCTGCGGACGCCGAGGCCGCGGAGCGC CGCGGGTCCGGCGCCCGCGGCCGTACTTCCAGCGGCCCCCGGACGAGGACACCAGTGAGGACGAGAACGT GTATGATTACATCGACGGCGATAGCAGCGACAGCGCCGACGACTACGATAGCGATTATTTTACTGCTAAC CGCGGCCCCAATCACGGCGCCGGCGATGCTATGGACACAGACGCACCACCCGAGCGCGCCCCGGAAGGGG GTGCCCCGCAAGACTACTTGACGGCCCACCTGCGCGCCATCGAGGTCCTGCCCGAGTCAGCGCCCCACCG GAGCCTGCTGGAGCGCACGGCCCGGACCGTGTATGCGCAGCAGTTTCCCCCGCGCGATTTGAGTGCGGGC TCCAAGGCGCCGGCACAGCGCGCGCGGCGGAGCCTCCGCGGCTTCCCGCGTGGCGGCGGGGGCGGCCAAG AACCCGGGCCAGACGACGAAGGCGACGACGCCGCAGACCTGCGCGAGGACCTTGTGCCAGACGAGGCCTA CGCGCACCTAGAGCGCGACGAGCGGCTGTCGGAAGGGCCCCCGCTCCTCAACATGGAGGCGGCCGCTGCG GCTGCGGGGGAGAGGAGCGTGGTGGAGGAGCTGTTTACGTACGCCCCTGCCCAGCCTCAGGTAGAGGTGC CGCTGCCCAGGATTTTGGAGGGCCGGGTGCGGCCCAGCGCCTTCTTCGCGCAGATGTCGCTGGACGCGCT GTGCCGCACGCCGCCCAACGATCAGCGCGTGGCGCGCGAGCGGCGCGCTTGGGAGATGGCCGGTACGCCG CATGGGCTCCTAATAACCACGTGGAGCACGGTGGACCCGGAATTCTCGATCGGCGGCATGTACGTGGGCG CCCCTGAGGGCACCCGGCCCCGGCTAGTGTGGCGGCGCGCGATGAAGCAGGCCATGGCGCTGCAGTACCG GCTGGGGGTGGGGGGCCTGTGCCGAGCAGTAGACGGCGCAGCATGCCGCCCACTGAGGCGCTGCTCTTTT TGGCGTGACGCGCTGCTGCGCGAGTGCGCAACTGCCATTTTTTGTCGCGGCCGGGGCGCGCGGGCGGCGC CGCGCCGCCTGCCGCGGCCGGCGGTTGGGCTGCTGGCAGCCACGCAGTTCACGCCACCGGACGCGTCCCC CCACGCGACGCTCTTTCGCGGCTCAATGGGTTCCCTGATTTACTGGCACGAGCTGCGCGTGATGCTGACT GCGGTGCCGGCCCTGTGCGCGCGCTACGCGGGCGCCGGGCTGCAGTCGGCCGAGCTGTACCTGCTGGCGC TACGGCACTCAGAGGCGCCCGGCTACACGGCAAATGAGCGCTACGCGCTCTCGGCGTACCTGACGCTGTT TGTAGCGCTCGCGGAGCGGGGCCTGCGCTGGCTGTATCTAGCGGGCGCGCACCTGCTCGGGCCGCACCCC ACAGCGGCGGCCTTCCGCGAAGTGCGCGCCAAGATCCCGTACGAGCGGCTGCCGCTAGGCAGCGCGACGC TGCACGACGCCGAAGTGGAGACGGTGGACTCGGCCACCTTCCAAGAGGCCCTGGCTTTTAGCGCGCTGGC ACATGTTTACGGGGAGGCCTACGTAGCGGTGCGAACCGCGACGACGCTGCTGATGGCCGAGTACGCGGTC CACGCTGAGCGCCGGGACGTGCGGCAGATGACAGCGGCCTTCCTGGGCGTGGGGCTGATCGCGCAGCGGC TGATGGGCAGCCTGAACCTGCTGCTGAACTGCGTAGCCGGCGCAGCGGTGTACGGGGGCCGGCGTGTGAC GGTGCGCGAGGGCACGCTCGCGCGGTACAGCCTGCTAGCGGACGCGGCACTGCCGCTGGTGCGCCCGGTG TTCCTGGTGGAGTTCCGGGAGGCCCGCGACGGCGTCATGCGCGAGCTGCGGCTGCGGCCCGTGGCGAGCC CGCCCCTGGCCGGCAAGCGGCGGGTCATGGAGCTGTACCTCTCGCTGGACAGCATAGAGGCGCTGGTCGG CCGCGAGCCGCTAGGTTCGCGGCCGGTGCTTGGGCCGCTCGTGGACATCGCGGAGGCGCTGGCGGACCAC CCGCACCTCGTCACGGGCGATGGGCGGGGCCCGCGCCTGGGCGGCCGCTAGGGCGACGGCCGCGCTTACG CGGCGCTGGGTCCGCCCACATCAGCCACCACGCCCGCGCGCCCGCCCCGCCCTCGTATGCCTATATAGCC ATCACGCTTGAATGCCAAGCGCCACTTTCCCGCCGCGGCGAAATGGCGTGGCCGGCCGCCTCTCGGGGCC TCATCGAGCGGCGGGCAGAGAAGGGGTGCCTGCTGCCGACGCTCGCAGATGCCACGGCCGCGGCCGTGGT GGCCTTGCAGGAGGCGACCGAGCCTCTGTGCGGGGCTCCGCTGTTTGGCGCCGAGCGCGCGGCCGCGCTG CTCGGCGTGCGCTCCAACGCCGTCCCGGAGGCGCTGGTTCTGTCGGACTCGGCGAAAGACGCCGACGACG AGTACCGGCTGGAGTATGACCGCGCCGCAGCGCGGGTGCTGGCGGGCGCGCGGCTCTCTAAGGACGCCGT CTGGCGCGCGGTCATCGGCTCGTACTGGAAGTACCTGAAGGCCTCGAGCGGCGCTGACGTGAACATCGAC GGCGCGGCCGGCGGCGCGGCGATGGAGCAGGCGCAGCTGACGAACGTGATGCTCTTTGCGCCCACATACG CGCGCCGGGCCTCGCGCTCGCCGTTCAAGCACAAGCAGGACAACGCGGCGTACAAAACCGCAGCGGCGGA GCTGCGCGGCGCCCTGCGCGCGGTGGAAAAGTATATGTATTACATGCGGCCGGGCGACCCCATGGTCGAA AGCCCCGACACGGAAGCCCGCCTGCAGGAAATTTTGGCGTACGCCGCGACGGCCTACCGCTGGCTGCTGT GGTTCATGGACGCGCTCGATGGCACGGTGCTGCGCAAGCTTGGCAAGCGCCCCTCGGCCGCGGTGGGGCC GCGCGAGCCGCGGCCGCCGGGCGAGCTGTGCGAGCGCCATCTGACCGGCGGCCCGGGGATCGCCTGCGGC AGCGGGGCCGCGCTCATGCTGACGGCCCTGACGGCGGCGGTGCTGGCCTTGCTACTGCGCGTCGGGGCCG CTTGGACGGAATCGTCATGGAAGAGCAATACGCAGGGCGTGACGGGAGCCATCGTCGCCGCGGTCGAGCT GGCGTCGGCCGTACACCACCACCTGCAGTACCTGCTCAACATGGCCTTTGTGGGGTACGCCTGCTGGCTG CGCGCGGGCGTGCGCGACCCGTACATGATCGCGGCCATCCGCGCGCAGTGCCGCTTCGCTCACTTTACGG GGCAGCTGATGCCGACCATGACTTCCGCCAGCTGGGCGGCCCTGGAGCGCGGCACGGCGAGCTGGTTTAA GCTGGCGCTGCTGAAAAGCGTGGCGGCGCACGGCGCGCAGACGCGCTACTACTCCAACATCGTGGAGTCG ATGCGGCTCGGCGGGAGCCGCGGGCTGCTGGCGCCGGTGCGCGCGCGGCCGTCGGGCCGCGGCCGCCGCT GCCCGCAGAGTCTGGCCGCGCGCCCCTTGCCCAGCCTGCCGGCCGCGGCCGCCGCCCCTCCGGGCTCGGG CTCGGGCTCGGGCTCGGGCTCTGACTCTGACTCCGACCTGGATCTCGGCTTTGCCCCCGCCGTCGGCGTC TATGCCTCGATGCGCAACCTGGAGGGCGCCTATGCCGACGCGGGCGGCCCGCTTTCGCCGGCGGCAAGCG CCGCGCGGCGGGAGGCGGCGGTGTACGAAAACGAAGGCGAGGGCGAATTCGCGCCTTTGCCCTCGGCGTT CGCCGAAGACGGCAGCTCCGACAGCGCCGACGAGCTCGCTATCGACGGCCCCATGCCTGCCCCGCCGCCC CGCGGTGGCCGCGGCGCCGACGAGCTCGCCATCGACGGTCCCATGCCTGCCCCGCCGCCCCGCGGCGGCC GCGGCGCCGACGAGCTCGCCATCGACGGCCCCATGCCTGCCCCGCCGCCCCGCGGCGGCCGCGGCGCCTC TGCTGGGCGCCTCCAGTACGCTGATTCGCGCGCCGTCTCGAGTGACGACGACGAGGACGAGGGCAAGGAC GAGGACGAGAACAAGGCCGGGGCGACCGCCCCGTTGGCCGCGGACCCCGAATCGGAACTGGCCCGCGCCA TGCGGCGTTGCAGCCTCCGCGTCCCGGCCTCGGCCCCGGCCCCGGCCCCGGCCCCGTGCACCGAGCGCCC GGGTAATCCAACCCGGTCTTACTCGCGCTCGCGCCCTCGGCTCCGCGCCCTAGACGACCGGCACGGCCTG GAGGCGCTGGCGGCTGCCGGTGCCGCTCACACCGCGCGCCACAACCGCGACGTGTGGCAGCGCTTTTCCC GCGTCTGCGAGGCCGGCGACGACTACGAAAACTACGACGAGGCCCGCGGCGCAGAGCGCGGACACCTCTC TTGCGCCTCCCGCGCGCGGCCTGAGGTGGAGAGGGTAACGTCGCTGTAAAGGCGCCCACCGCAAACGCTG TAACACACACACAATAA
Protein Sequence	>gi\|9629828\|ref\|NP_045312.1\| tegument protein VP13/14 [Bovine herpesvirus 1] MDAARDGRPERRRAVSGTYRTHPFQRPSARRSAGRPARCGRRGRGAPRVRRPRPYFQRPPDEDTSEDENV YDYIDGDSSDSADDYDSDYFTANRGPNHGAGDAMDTDAPPERAPEGGAPQDYLTAHLRAIEVLPESAPHR SLLERTARTVYAQQFPPRDLSAGSKAPAQRARRSLRGFPRGGGGGQEPGPDDEGDDAADLREDLVPDEAY AHLERDERLSEGPPLLNMEAAAAAAGERSVVEELFTYAPAQPQVEVPLPRILEGRVRPSAFFAQMSLDAL CRTPPNDQRVARERRAWEMAGTPHGLLITTWSTVDPEFSIGGMYVGAPEGTRPRLVWRRAMKQAMALQYR LGVGGLCRAVDGAACRPLRRCSFWRDALLRECATAIFCRGRGARAAPRRLPRPAVGLLAATQFTPPDASP HATLFRGSMGSLIYWHELRVMLTAVPALCARYAGAGLQSAELYLLALRHSEAPGYTANERYALSAYLTLF VALAERGLRWLYLAGAHLLGPHPTAAAFREVRAKIPYERLPLGSATLHDAEVETVDSATFQEALAFSALA HVYGEAYVAVRTATTLLMAEYAVHAERRDVRQMTAAFLGVGLIAQRLMGSLNLLLNCVAGAAVYGGRRVT VREGTLARYSLLADAALPLVRPVFLVEFREARDGVMRELRLRPVASPPLAGKRRVMELYLSLDSIEALVG REPLGSRPVLGPLVDIAEALADHPHLVTGDGRGPRLGGR
Molecule Role	Virulence factor
Molecule Role Annotation	The U(L)47 deletion mutant exhibited reduced plaque size and more than 100-fold decrease in intracellular and extracellular viral titers in cultured cells. the U(L)47 gene product was indispensable for BHV-1 replication in vivo, since no clinical manifestations or viral shedding were detected in the U(L)47 deletion mutant-infected calves, and the virus failed to induce significant levels of humoral and cellular immunity. (Lobanov et al., 2010)
References	*Lobanov et al., 2010:* Lobanov VA, Maher-Sturgess SL, Snider MG, Lawman Z, Babiuk LA, van Drunen Littel-van den Hurk S. A UL47 gene deletion mutant of bovine herpesvirus type 1 exhibits impaired growth in cell culture and lack of virulence in cattle. Journal of virology. 2010; 84(1); 445-458. [PubMed: 19864376].


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UL47