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BICP0

Victor ID 5056
Gene Name BICP0
Sequence Strain (Species/Organism) Bovine herpesvirus 1
NCBI Gene ID 1487364
NCBI Protein GI 9629879
Locus Tag BoHV1_gp35
Genbank Accession M84465
Protein Accession NP_045363
Taxonomy ID 10320
Gene Starting Position 100474
Gene Ending Position 102699
Gene Strand (Orientation) -
Protein Name ubiquitin E3 ligase ICP0
Protein pI 5.29
Protein Weight 64900.48
Protein Length 676
DNA Sequence 
>gi|9629818:100474-102699 Bovine herpesvirus 1, complete genome
TTTTATTGATTGCGCATGCGCGACCTGGGCCATAAAAGCCCCGCGCATGCGCGAGCAGTTACTTTCGGTT
TGGGGATGACAGCGGCGACTGCGGCTCGAAAGTTAAGTATGCAGGCTGGGGGTCGCAAATACACGGCGGT
GCGGTGTGGTGGGCTGCGGGTCGCGGAGTGGGTGGGCGGGGAGCCGGCCGCGGCGATTATTGCCGCCAGG
CGCTGCCGCCGCTGCAGCGGCCGAGCAGCCCGGCCAGGCTCGGGCCCTGGCGACCGCCTGGCTGCGGCGC
CAGGGCCGCGCTGCTGCGGCGGGGGGTCCCCAGGAGGCTTTCTCGCACCCAGGCGGCCACTTCCATTTCG
GTGCGCCGCCTCTTCTGCGCCGAGCTCTCGGGGCCGGGGTCCAGGTCGCCCCGCGCCATGGCGCTCGCTG
GCCTTCTCTCCCGGCCGGGGTTGCCATTGCGGCCGACCTCGGCCCGGGCGGCTCCGGCCAGGGCCGGAGC
GCCGGCCCGCCGGGGGTCGGCGGCAGGGGCGCGGCCGGCGGGAGACGGGGTCGGGGCTCGGGTGGAAATA
GCCGCGGCGGTGCTGGTAGCCGCCGCGGTAACAGCGGGGCTCGGCGCCGAGCTCCGAGCGACGGAAGGTG
CCGCCGCGGCGGCAGTTACTGCCGCCGCCGCGGCCGGGGTCCCAATTTGCGCACCCGCCGAGGCCGGCCC
CGGGGCCGCCGCGGGGGCCGGGTCGGCGGGGCGGGCGGGCGCGTTCGCCGTCAGGTCTATCACTGTGGAG
ATGGGCGCGGGGGCTGGGGCCGGGGCCGGGGCCGGGGTCGGGGCGCGGTCTAACTCTGTCCTTCTTCTCC
GGCGGGCCTGCACACGGGGAGGCCCAGCCTCCCCGAGCAGCCTGGCCCGGCGCTCCCCTCGTCCCTCCTC
ACTGCCCGCCCCCCAGCCCGCGGTCTCTCCCGCCGCGACTCCCAAGCCCGCTCCCCTCCCCTCTTCTCTG
GGCTCGGGGCTGCATGCGCGCGCTTGCGCCGCGGGGGCTGCCCGCGGCGCCGCCGGCAATCGGGGGTCTC
GTCTCCCGCCGCGGCTCCGAGAGCTGGGGGGCGCGGAAACTGCCGCCGCGCGGCCGCAAGGGCGGCGCGC
TAGCGACCGAGGCGCCGGCTGCACCGCGGGTGTTTGTCGACCTCTAGTGCTGACATACTGTCTTTCCGCA
GGCCGCCGAGCCCGGGCCGCGCCAGACGCCCCCCGCGTGCGCCTCGACTCAACCTCCGCGTCCGTCTCCG
GCTCCGTTTCCGTGTCGTCAATGGCGGTCAGGTCGGAGGTGCTGAGCCCCGACGACGACTCTTCTGACTC
CGACCAAGAGTCGTCCTCCGAGCCCTCCGAGTCCGAGTCCGAGGTGTCGAGAAACACCACCCCACGGCCG
CCAGGAGGCGCAGACTGCTGAGGGATGAGGTGCGAGGGGCCCACCGTCACGCAGCGCGCCGCCACGAACA
ACAGGCTGCGCACAAACGCGGGGGCGTCGTCCTCGCCAATCAGGGGCTCCATCGCGTCGGCCAGCCCGTC
GTCGTCGAAGCCGCACTCGGCCAGCATCGCCATCACGTAGTCCGTCATGGCCGCGAGCTCGCGGGCCGTC
ACGGCAAAGCTGCCCACCAGAGCGCCCTCGACCCACTCCACCACCCGCCGCAGGTACGGGGCCCCCGGCC
CATGCTCCGGCGTGTTCGGCAGCAAGGGCAGGCGCGGGCCGCGCGCGACCCGGTCAATAAACTCCTGCGC
CGCGTCCGCGCCTCGCCCCGCGCGCCCCCCGGCCGCTCCGGCCGCCCTGCCCGCCCCGGCGCCTCTGGCC
TCCCCGGCCTCCTCCGCCCCCCCGGCCCCGCCGCCGGCCTCGCTCCCGTCCGCGGCCCCGGCTTCCCCGC
CGGCCCCCGAGGCCTCGCCGTCGGCCGCCGTGAGGTCGATGGGCCCGGCGTCGTAGTCCTCGCCCCAGAT
GACGGCCGCGTCCGGCTCCAACGCGCCGTCCGCCCCCGGCCCTCCCCCCACAGGGATCTCCTCGAAGCAC
TCATCCGAGGCGACGCTGTGGATGAGAGACTGCACGGGCGCCTTGCACAGCGGGCAGGTCGGGCGCCCCT
CCAGCCACCGGCGGATGCAGGCCAGGCAGAAGGCGTGCAGGCAGGGCAGAGCGCGCGCCGCGCCGGTGAT
CGCGTCCAGGCAGATGCAGCACGATCCCAGCTCTGGGGCAGCGGCGGGCGGCGCCA
Protein Sequence 
>gi|9629879|ref|NP_045363.1| ubiquitin E3 ligase ICP0 [Bovine herpesvirus 1]
MAPPAAAPELGSCCICLDAITGAARALPCLHAFCLACIRRWLEGRPTCPLCKAPVQSLIHSVASDECFEE
IPVGGGPGADGALEPDAAVIWGEDYDAGPIDLTAADGEASGAGGEAGAADGSEAGGGAGGAEEAGEARGA
GAGRAAGAAGGRAGRGADAAQEFIDRVARGPRLPLLPNTPEHGPGAPYLRRVVEWVEGALVGSFAVTARE
LAAMTDYVMAMLAECGFDDDGLADAMEPLIGEDDAPAFVRSLLFVAARCVTVGPSHLIPQQSAPPGGRGV
VFLDTSDSDSEGSEDDSWSESEESSSGLSTSDLTAIDDTETEPETDAEVESRRTRGASGAARARRPAERQ
YVSTRGRQTPAVQPAPRSLARRPCGRAAAVSAPPSSRSRGGRRDPRLPAAPRAAPAAQARACSPEPREEG
RGAGLGVAAGETAGWGAGSEEGRGERRARLLGEAGPPRVQARRRRRTELDRAPTPAPAPAPAPAPISTVI
DLTANAPARPADPAPAAAPGPASAGAQIGTPAAAAAVTAAAAAPSVARSSAPSPAVTAAATSTAAAISTR
APTPSPAGRAPAADPRRAGAPALAGAARAEVGRNGNPGRERRPASAMARGDLDPGPESSAQKRRRTEMEV
AAWVRESLLGTPRRSSAALAPQPGGRQGPSLAGLLGRCSGGSAWRQ
Molecule Role Virulence factor
Molecule Role Annotation During acute infection of calves, levels of infectious virus were 2 to 3 logs lower in ocular or nasal swabs with 51g than with 51gR. Calves latently infected with the 51g mutant did not reactivate from latency because virus shedding did not occur in ocular or nasal cavities. (Saira et al., 2008)
References
Saira et al., 2008: Saira K, Chowdhury S, Gaudreault N, da Silva L, Henderson G, Doster A, Jones C. The zinc RING finger of bovine herpesvirus 1-encoded bICP0 protein is crucial for viral replication and virulence. Journal of virology. 2008; 82(24); 12060-12068. [PubMed: 18842710].