| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
exgmp |
Leishmania mexicana MNYC/BZ/62/M379 |
|
|
12584592
|
|
|
|
GDP-mannose pyrophosphorylase |
Virulence factor |
MUTATION: GDPMP (exgmp) mutant is unable to infect macrophages or mice [Ref7256:Garami and Ilg, 2001].
|
11447107
|
|
|
pmm |
Leishmania mexicana M379 |
|
|
15387672
|
|
|
|
phosphomannomutase |
Virulence factor |
MUTATION: PMM mutant is attenuated in mice and murine macrophages [Ref7257:Garami et al., 2001].
|
11689705
|
|
|
Cht1 |
Leishmania mexicana M379 |
|
|
48375060
|
|
|
|
chitinase |
Virulence factor |
MUTATION: Overexpression of Cht1 in L. mexicana increased survival within sandfly vector, and more virulent infections in mice [Ref7258:Rogers et al., 2008].
|
18284631
|
|
|
PMI |
Leishmania mexicana MHOM/GT/2001/U1103 |
13453593
|
|
401427037
|
LMXM_31_1580 |
FR799584 |
XP_003878002 |
|
Virulence factor |
The Delta lmexpmi mutant is attenuated in infections of macrophages in vitro and of mice. [Ref7565:Garami and Ilg, 2001] |
11084042
|
|
|
LMCPB |
|
|
|
1730100
|
|
|
|
Cysteine proteinase B |
Virulence factor |
deletion of the entire multicopy cysteine protease B (CPB) gene array in L. mexicana is associated with decreased parasite virulence. [Ref7566:Buxbaum et al., 2003] |
14500670
|
|
|
ICP |
Leishmania mexicana MHOM/GT/2001/U1103 |
13448953
|
|
401423014
|
LMXM_24_1770 |
FR799577 |
XP_003875994 |
|
Virulence factor |
Null mutants grew normally in vitro, were as infective to macrophages in vitro as wild-type parasites, but had reduced infectivity to mice. Mutants re-expressing ICP from a single gene gave partial restoration of virulence in vivo, whereas mutants overexpressing ICP secreted the inhibitor and showed markedly reduced virulence in mice.[Ref7568:Besteiro et al., 2004]
|
15554964
|
|
|
LmexCht1 |
Leishmania mexicana MHOM/GT/2001/U1103 |
13450317
|
|
401418548
|
LMXM_16_0790 |
FR799569 |
XP_003873765 |
|
Virulence factor |
the LmexCht1 transfectants survived significantly better in human macrophages and also produced significantly larger lesions in mice than control parasites.
[Ref7611:Joshi et al., 2005] |
15561707
|
