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exgmp

Victor ID 4829
Gene Name exgmp
Sequence Strain (Species/Organism) Leishmania mexicana MNYC/BZ/62/M379
NCBI Protein GI 12584592
Other Database IDs CDD:31401
CDD:133047
CDD:107413
CDD:100038
GOA:Q9BLW4
HSSP: P26396
InterPro: IPR001451
InterPro: IPR005835
InterPro: IPR011004
UniProtKB/TrEMBL: Q9BLW4
Taxonomy ID 5665
Gene Strand (Orientation) ?
Protein Name GDP-mannose pyrophosphorylase
Protein Length 379
Protein Note Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; COG1208
Protein Sequence 
>gi|12584592|emb|CAC27419.1| GDP-mannose pyrophosphorylase [Leishmania mexicana]
MSASDGQGMRAVILVGGFGTRLRPLTLTTPKPLVPFCNKPMIIHQIEALKAVGVTEVILAVAYRPEAMKE
QMDEWSRKLGVSFVFSVEEDPLGTAGPLALARDILMQDDKPFFVLNSDVTCMFPLQELLDFHKARGGEGT
IMVSQVTQWEKYGVVVYSQQSYQIERFVEKPSSFLGDRVNAGIYIFNKSILDRIPPCRTSIEKEIFPAMA
AEGELYAFNLEGFWMDVGQPKDYILGMTKFIPSLLDGDRKTEQLHTEATEHQHGGRFTVVGASLIDPSAK
IGDGAVIGPCASIGANCVIGESCRIDNAAILENSKVGKGTMVSRSIVGWNNRIGSWCHIEDISVLGDDVE
VKDGVVLIGTKVLPNKDVGEHHFQAGIIM
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: GDPMP (exgmp) mutant is unable to infect macrophages or mice (Garami and Ilg, 2001).
References
Garami and Ilg, 2001: Garami A, Ilg T. Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability. The EMBO journal. 2001; 20(14); 3657-3666. [PubMed: 11447107].