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Cht1

Victor ID 4831
Gene Name Cht1
Sequence Strain (Species/Organism) Leishmania mexicana M379
NCBI Protein GI 48375060
Other Database IDs CDD:144344
CDD:119349
Taxonomy ID 5665
Gene Strand (Orientation) ?
Protein Name chitinase
Protein Length 457
Protein Note Glycosyl hydrolases family 18; pfam00704
Protein Sequence 
>gi|48375060|gb|AAT42197.1| chitinase [Leishmania mexicana]
MVQRSSLVQLACLVAALYSSCVSTPVSSAIAAAAPAAAGDTAIGSGHNTSITAASPPPLFTVFGYLPEYR
QDSFHYEAFFNAGLTHLIFFSAEVDPATLRLIHVDDRLPSGDEWARIRRLADLHGAQLMLCIGGGGRSAG
FADLVGDTVRRRAFIEEVNAVLLARKLDGIDFNWEYPQTMTEWLNFGRFLMELRSSLGYAAAAGDEHAGK
PAGERRHRLRVRRAVLSMALHPHPSMAAVLQSARVLHSLDYVHLMAYDHAVGTGPHSSVEYAASVLSEGT
IGLFNEGIYNRRLGQMHQRPRIIQDHRRKLTLGIPFYGRHREDRRLQPEAYDRLWLFIQEWASKNHPTWV
EGGAELRALSEYGGYSFTGYDDVKRKMRLARAANLSGIMIWELGQDCPPGTSPMSLMTAVHEQLADWGLL
TDSRHGSGGNVNSGNAYDCPQPLPQDSSPDVADDRDL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Overexpression of Cht1 in L. mexicana increased survival within sandfly vector, and more virulent infections in mice (Rogers et al., 2008).
References
Rogers et al., 2008: Rogers ME, Hajmová M, Joshi MB, Sadlova J, Dwyer DM, Volf P, Bates PA. Leishmania chitinase facilitates colonization of sand fly vectors and enhances transmission to mice. Cellular microbiology. 2008; 10(6); 1363-1372. [PubMed: 18284631].