Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

ICP

Victor ID 5169
Gene Name ICP
Sequence Strain (Species/Organism) Leishmania mexicana MHOM/GT/2001/U1103
NCBI Gene ID 13448953
NCBI Protein GI 401423014
Locus Tag LMXM_24_1770
Genbank Accession FR799577
Protein Accession XP_003875994
Taxonomy ID 929439
Chromosome No 24
Gene Starting Position 662599
Gene Ending Position 662940
Gene Strand (Orientation) -
Protein pI 9.41
Protein Weight 11245.1
Protein Length 113
DNA Sequence 
>gi|401423131:662599-662940 Leishmania mexicana MHOM/GT/2001/U1103 complete genome, chromosome 24
TCTACTTCACGTTGAGGTGCAACGTGTACCGCTCGTTTTCTGGCTTGATGCCCTCGAAGGGGCGCGTGTA
GACCAGCTCCAGCGTGTGATGGCCCCTTTTCCGCGGTTTCACGAGCACAACGTAGATGCCACCAACTCCC
ACCATAGGAGTCGAGGATGGTGTCGGCGTGTACTTGCAGACAACTTCCAGGATCTCATCGCTGAGCACAT
CTTTGCCCACAAAACCAACGCGCGTCCACATGTATCCAGTGGTCGGGTTGCCCTTCAGGTGGATCTCGGT
CGTTTTGCCGACATGCGTGTCCACCCACTTGTCGTTGTCCTTCACACTGAGCGGGGCGATCA
Protein Sequence 
>gi|401423014|ref|XP_003875994.1| inhibitor of cysteine peptidase [Leishmania mexicana MHOM/GT/2001/U1103]
MIAPLSVKDNDKWVDTHVGKTTEIHLKGNPTTGYMWTRVGFVGKDVLSDEILEVVCKYTPTPSSTPMVGV
GGIYVVLVKPRKRGHHTLELVYTRPFEGIKPENERYTLHLNVK
Molecule Role Virulence factor
Molecule Role Annotation Null mutants grew normally in vitro, were as infective to macrophages in vitro as wild-type parasites, but had reduced infectivity to mice. Mutants re-expressing ICP from a single gene gave partial restoration of virulence in vivo, whereas mutants overexpressing ICP secreted the inhibitor and showed markedly reduced virulence in mice.(Besteiro et al., 2004)
References