| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
E(rns) |
Classical swine fever virus - Brescia |
|
|
130457
|
|
|
|
Genome polyprotein |
Virulence factor |
MUTATION: An N269A/Q mutation in the E(rns) protein created an attenuated mutant in swine [Ref7335:Sainz et al., 2008]. |
17904607
|
|
|
E1 |
Classical swine fever virus - Brescia |
|
325460
|
325461
|
|
|
AAA43843.1 |
protein precursor |
Virulence factor |
MUTATION: An N to A amino acid substitution was made in the N594 site of the E1 glycoprotein, resulting in attenuation of the virus in swine [Ref7336:Fernandez-Sainz et al., 2009]. |
19203774
|
|
|
E2 |
Classical swine fever virus |
920146
|
|
12657942
|
PestiV2gp1 |
AF326963 |
NP_075354 |
polyprotein |
Virulence factor |
MUTATION: A E2 mutant in Classical swine fever virus is attenuated in pigs [Ref7377:Maurer et al., 2005]. |
15837238
|
|
|
P7 |
|
|
|
27885149
|
|
|
|
nonstructural protein p7 |
Virulence factor |
Using reverse genetics, partial in-frame deletions of p7 were deleterious for virus growth, demonstrating that CSFV p7 function is critical for virus production in cell cultures. A panel of recombinant mutant CSFVs was created using alanine scanning mutagenesis of the p7 gene harboring sequential three- to six-amino-acid residue substitutions spanning the entire protein. These recombinant viruses allowed the identification of the regions within p7 that are critical for virus production in vitro. In vivo, some of these viruses were partially or completely attenuated in swine relative to the highly virulent parental CSFV Brescia strain, indicating a significant role of p7 in CSFV virulence [Ref7527:Gladue et al., 2012]. |
22496228
|
|
|
N-Pro |
|
|
|
27885143
|
|
|
|
N-Pro |
Virulence factor |
Here, for the moderately virulent CSFV strain Alfort/187 as well as for the highly virulent strain Eystrup we show that the respective N(pro)-deleted viruses are attenuated. Vaccination of pigs with either of the two deletion mutants resulted in the induction of a strong antibody response. Animals were protected against challenge with a lethal dose of highly virulent CSFV indicating that N(pro) deletion mutants are excellent candidates for a modified live virus vaccine. [Ref7496:Mayer et al., 2004]
|
14670312
|
|
|
NS4B |
|
|
|
27885153
|
|
|
|
nonstructural protein NS4B |
Virulence factor |
NS4B.VGIv showed an attenuated phenotype in swine, displaying reduced replication in the oronasal cavity and limited spread from the inoculation site to secondary target organs [Ref7336:Fernandez-Sainz et al., 2009]. |
19203774
|
