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N-Pro

Victor ID 5096
Gene Name N-Pro
NCBI Protein GI 27885143
Other Database IDs CDD:147625
Taxonomy ID 11096
Gene Strand (Orientation) ?
Protein Name N-Pro
Protein Length 168
Protein Note Pestivirus type 2
Protein Sequence 
>gi|27885143|ref|NP_777494.1| N-Pro [Classical swine fever virus]
MELNHFELLYKTNKQKPMGVEEPVYDATGRPLFGDPSEVHPQSTLKLPHDRGRGNIKTTLKNLPRKGDCR
SGNHLGPVSGIYVKPGPVFYQDYMGPVYHRAPLEFFNEAQFCEVTKRIGRVTGSDGKLYHIYVCIDGCIL
LKLAKRDEPRTLKWIRNFTDCPLWVTSC
Molecule Role Virulence factor
Molecule Role Annotation Here, for the moderately virulent CSFV strain Alfort/187 as well as for the highly virulent strain Eystrup we show that the respective N(pro)-deleted viruses are attenuated. Vaccination of pigs with either of the two deletion mutants resulted in the induction of a strong antibody response. Animals were protected against challenge with a lethal dose of highly virulent CSFV indicating that N(pro) deletion mutants are excellent candidates for a modified live virus vaccine. (Mayer et al., 2004)
References
Mayer et al., 2004: Mayer D, Hofmann MA, Tratschin JD. Attenuation of classical swine fever virus by deletion of the viral N(pro) gene. Vaccine. 2004; 22(3-4); 317-328. [PubMed: 14670312].