| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
NS1 |
Influenza A virus (A/Puerto Rico/8/34(H1N1)) |
956533
|
|
8486133
|
FLUAVs8gp2 |
J02150 |
NP_040984 |
nonstructural protein NS1 |
Virulence factor |
MUTATION: Influenza virus with a deletion of the NS1 gene were highly attenuated in mice [Ref7259:GarcÃa-Sastre et al., 1998].
|
9878611
|
|
|
PB1 |
Influenza A virus (A/Puerto Rico/8/34(H1N1)) |
956534
|
|
8486135
|
FLUAVs2gp1 |
J02151 |
NP_040985 |
polymerase 1 |
Virulence factor |
MUTATION: mutations eliminating expression of PB1F2 without afffecting the PB1 open reading frame were attenuating following intranasal inoculation [Ref7260:Zamarin et al., 2006].
|
16873254
|
|
|
M2 |
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
956528
|
|
56583270
|
FLUAVs7gp2 |
V01099 |
NP_040979 |
matrix protein 2 |
Virulence factor |
MUTATION: Mutant influenza virus that lacks the transmembrane and cytoplasmic tail domains of M2 (M2 knockout [M2KO]) from Influenza A virus (A/Puerto Rico/8/34(H1N1)) is attenuated in both cell culture and mice [Ref7399:Watanabe et al., 2009]. |
19321619
|
|
|
HA |
|
|
159144920
|
159144921
|
|
|
ABW90135.1 |
hemagglutinin |
Virulence factor |
Determination of virulence for mice indicated that amino acid substitution in the HA gene of a low-virulent escape mutant produced a decrease of virulence whereas the additional mutation identical to that acquired by the escape mutant in the course of readaptation restored the virulence to initial level. The findings are the first strong evidence for lower H5N1 virus virulence resulting from the amino acid substitution changing the antigenic specificity of HA and for restored virulence arising from compensating mutation in the HA gene.[Ref7490:Krylov et al., 2010] |
21260989
|
|
|
PB2 |
Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) |
3654615
|
|
73852947
|
FLUAVH5N1_s1gp1 |
AF144300 |
YP_308664 |
polymerase PB2 |
Virulence factor |
The recombinant viruses with the PB2 (63T) mutation were less pathogenic to mice. [Ref7506:Li et al., 2011] |
21367983
|
|
|
PA |
Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) |
3654617
|
|
73852951
|
FLUAVH5N1_s3gp1 |
AF144302 |
YP_308666 |
polymerase PA |
Virulence factor |
The virulence of the reassortant bearing the PA gene from DK/49 in the GS/65 background increased 10(5)-fold relative to that of the GS/65 virus. [Ref7507:Song et al., 2011] |
21177821
|
