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NS1

Victor ID 4832
Gene Name NS1
Sequence Strain (Species/Organism) Influenza A virus (A/Puerto Rico/8/34(H1N1))
NCBI Gene ID 956533
NCBI Protein GI 8486133
Locus Tag FLUAVs8gp2
Genbank Accession J02150
Protein Accession NP_040984
Taxonomy ID 211044
Gene Starting Position 26
Gene Ending Position 718
Gene Strand (Orientation) +
Protein Name nonstructural protein NS1
Protein pI 6.56
Protein Weight 24393.15
Protein Length 230
DNA Sequence 
>gi|8486131:26-718 Influenza A virus (A/Puerto Rico/8/34(H1N1)) segment 8, complete sequence
AATGGATCCAAACACTGTGTCAAGCTTTCAGGTAGATTGCTTTCTTTGGCATGTCCGCAAACGAGTTGCA
GACCAAGAACTAGGTGATGCCCCATTCCTTGATCGGCTTCGCCGAGATCAGAAATCCCTAAGAGGAAGGG
GCAGCACTCTTGGTCTGGACATCGAGACAGCCACACGTGCTGGAAAGCAGATAGTGGAGCGGATTCTGAA
AGAAGAATCCGATGAGGCACTTAAAATGACCATGGCCTCTGTACCTGCGTCGCGTTACCTAACCGACATG
ACTCTTGAGGAAATGTCAAGGGAATGGTCCATGCTCATACCCAAGCAGAAAGTGGCAGGCCCTCTTTGTA
TCAGAATGGACCAGGCGATCATGGATAAAAACATCATACTGAAAGCGAACTTCAGTGTGATTTTTGACCG
GCTGGAGACTCTAATATTGCTAAGGGCTTTCACCGAAGAGGGAGCAATTGTTGGCGAAATTTCACCATTG
CCTTCTCTTCCAGGACATACTGCTGAGGATGTCAAAAATGCAGTTGGAGTCCTCATCGGAGGACTTGAAT
GGAATGATAACACAGTTCGAGTCTCTGAAACTCTACAGAGATTCGCTTGGAGAAGCAGTAATGAGAATGG
GAGACCTCCACTCACTCCAAAACAGAAACGAGAAATGGCGGGAACAATTAGGTCAGAAGTTTG
Protein Sequence 
>gi|8486133|ref|NP_040984.1| nonstructural protein NS1 [Influenza A virus (A/Puerto Rico/8/34(H1N1))]
MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILK
EESDEALKMTMASVPASRYLTDMTLEEMSREWSMLIPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDR
LETLILLRAFTEEGAIVGEISPLPSLPGHTAEDVKNAVGVLIGGLEWNDNTVRVSETLQRFAWRSSNENG
RPPLTPKQKREMAGTIRSEV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Influenza virus with a deletion of the NS1 gene were highly attenuated in mice (García-Sastre et al., 1998).
References
García-Sastre et al., 1998: García-Sastre A, Egorov A, Matassov D, Brandt S, Levy DE, Durbin JE, Palese P, Muster T. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology. 1998; 252(2); 324-330. [PubMed: 9878611].