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PA

Victor ID 5117
Gene Name PA
Sequence Strain (Species/Organism) Influenza A virus (A/goose/Guangdong/1/1996(H5N1))
NCBI Gene ID 3654617
NCBI Protein GI 73852951
Locus Tag FLUAVH5N1_s3gp1
Genbank Accession AF144302
Protein Accession YP_308666
Taxonomy ID 93838
Segment No segment 3
Gene Starting Position 24
Gene Ending Position 2174
Gene Strand (Orientation) +
Protein Name polymerase PA
Protein pI 5.39
Protein Weight 79693.97
Protein Length 716
DNA Sequence 
>gi|73852950:24-2174 Influenza A virus (A/Goose/Guangdong/1/96(H5N1)), complete genome
AATGGAAGACTTTGTGCGACAATGCTTCAATCCAATGATTGTCGAGCTTGCGGAAAAGGCAATGAAAGAA
TATGGGGAAGATCCGAAAATCGAAACGAACAAATTTGCCGCAATATGCACGCACTTAGAAGTCTGTTTCA
TGTATTCAGATTTCCACTTTATTGATGAACGGGGCGAATCAACAATTATAGAATCTGGCGATCCCAATGC
ATTATTGAAACACCGGTTTGAAATAATCGAAGGGAGGGACCGAACAATGGCCTGGACAGTGGTGAATAGT
ATCTGCAACACCACAGGAGTTGAGAAGCCTAAATTTCTCCCAGATTTGTATGACTACAAGGAGAACCGAT
TTATTGAAATTGGAGTGACACGGAGGGAAGTTCACACATACTATCTAGAAAAAGCCAACAAGATAAAATC
TGAGAAGACACACATTCACATATTCTCATTCACTGGAGAGGAAATGGCCACCAAAGCGGACTACACCCTT
GATGAAGAAAGCAGGGCCCGAATCAAAACCAGGCTGTTCACTATAAGGCAGGAAATGGCCAGTAGGGGTT
TATGGGATTCCTTTCGTCAGTCCGAGAGAGGCGAAGAGACAGTTGAAGAAAGATTTGAAATCACAGGGAC
TATGTGCAGGCTTGCCGACCAAAGTCTCCCACCTAATTTCTCCAGCCTTGAAAAATTTAGAGCCTATGTG
GATGGATTCGAACCGAACGGCTGCATTGAGGGCAAGCTTTCTCAAATGTCGAAAGAAGTAAACGCCAGAA
TTGAGCCATTTCTGAAGACAACACCACGCCCTCTTAGATTACCTGATGGGCCTCCCTGCTCTCAGCGGTC
GAAGTTTTTGCTGATGGATGCCCTTAAATTAAGCATCGAAGACCCGAGTCATGAGGGGGAGGGGATACCG
CTATATGATGCAATCAAATGCATGAAAACATTTTTCGGCTGGAAAGAGCCCAACATTGTAAAACCACATG
AAAAAGGCATAAACCCCAATTACCTCCTGGCTTGGAAGCAGGTGCTGGCAGAGCTCCAAGATATTGAAAA
CGAGGAGAAAATTCCAAAGACAAAGAACATGAGGAAAACAAGCCAATTGAAGTGGGCACTTGGTGAGAAT
ATGGCACCAGAGAAAGTAGACTTTGAGGATTGCAAAGATGTTAGCGATCTAAGGCAGTATGACAGTGATG
AACCAAAGCCTAGATCACTAGCAAGCTGGATCCAGAGTGAATTCAACAAGGCATGCGAATTGACAGATTC
AAGTTGGATTGAACTTGATGAAATAGGGGAAGACGTTGCTCCAATTGAGCACATTGCAAGTATGAGAAGG
AACTATTTCACAGCGGAAGTATCCCATTGCAGGGCTACTGAATACATAATGAAGGGAGTGTACATAAACA
CAGCTTTGTTGAATGCATCCTGTGCAGCCATGGATGACTTCCAACTGATCCCAATGATAAGCAAATGCAG
AACCAAAGAAGGAAGACGGAAAACTAACCTGTATGGATTCCTTATAAAAGGAAGATCCCATTTGAGAAAT
GACACCGATGTGGTAAACTTTGTGAGTATGGAATTCTCTCTTACTGATCCGAGGCTGGAGCCACACAGAT
GGGAAAAGTACTGCGTTCTTCGGATAGGAGACATGCTCTTACGGACTGAAATAGGCCAAGTGTCAAGGCC
CATGTTTCTTTATGTGAGAACCAATGGAACCTCCAAGATCAAGATGAAATGGGGCATGGAAATGAGGCGA
TGCCCTTTTCAATCCCTTCAACAGATTGAGAGCATGATTGAGGCCGAGTCTTCTGTCAAAGAAAAAGACA
TGACTAAAGAATTCTTTGAAAACAAATCAGAAACATGGCCAATTGGAGAATCACCCAAGGGAGTGGAGGA
AGGCTCCATCGGGAAGGTGTGCAGAACCTTACTGGCTAAATCTGTTTTCAACAGTCTATATGCATCTCCA
CAACTCGAGGGGTTTTCAGCTGAATCAAGAAAATTGCTTCTCATTGTTCAGGCACTTAGGGACAACCTGG
AACCTGGAACCTTCGATCTTGGGGGGCTATATGAAGCAATTGAGGAGTGCCTGATTAATGATCCCTGGGT
TTTGCTTAATGCATCTTGGTTCAACTCCTTCCTCACACATGCACTAAGATA
Protein Sequence 
>gi|73852951|ref|YP_308666.1| polymerase PA [Influenza A virus (A/goose/Guangdong/1/1996(H5N1))]
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESTIIESGDPNA
LLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKS
EKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETVEERFEITGT
MCRLADQSLPPNFSSLEKFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRS
KFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLLAWKQVLAELQDIEN
EEKIPKTKNMRKTSQLKWALGENMAPEKVDFEDCKDVSDLRQYDSDEPKPRSLASWIQSEFNKACELTDS
SWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCR
TKEGRRKTNLYGFLIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHRWEKYCVLRIGDMLLRTEIGQVSRP
MFLYVRTNGTSKIKMKWGMEMRRCPFQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEE
GSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV
LLNASWFNSFLTHALR
Molecule Role Virulence factor
Molecule Role Annotation The virulence of the reassortant bearing the PA gene from DK/49 in the GS/65 background increased 10(5)-fold relative to that of the GS/65 virus. (Song et al., 2011)
References
Song et al., 2011: Song J, Feng H, Xu J, Zhao D, Shi J, Li Y, Deng G, Jiang Y, Li X, Zhu P, Guan Y, Bu Z, Kawaoka Y, Chen H. The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks. Journal of virology. 2011; 85(5); 2180-2188. [PubMed: 21177821].