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PB2

Victor ID 5116
Gene Name PB2
Sequence Strain (Species/Organism) Influenza A virus (A/goose/Guangdong/1/1996(H5N1))
NCBI Gene ID 3654615
NCBI Protein GI 73852947
Locus Tag FLUAVH5N1_s1gp1
Genbank Accession AF144300
Protein Accession YP_308664
Taxonomy ID 93838
Segment No segment 1
Gene Starting Position 27
Gene Ending Position 2306
Gene Strand (Orientation) +
Protein Name polymerase PB2
Protein pI 9.89
Protein Weight 79721.84
Protein Length 759
DNA Sequence 
>gi|73852946:27-2306 Influenza A virus (A/Goose/Guangdong/1/96(H5N1)), complete genome
TATGGAAAGAATAAAAGAACTAAGAGATCTAATGTCGCAGTCCCGCACTCGCGAGATACTAACAAAAACC
ACTGTGGATCATATGGCCATAATCAAGAAATACACATCAGGAAGACAAGAGAAGAACCCTGCTCTCAGAA
TGAAATGGATGATGGCAATGAAATATCCAATCACAGCAGACAAGAGAATAATGGAGATGATTCCTGAAAG
GAATGAGCAAGGACAAACGCTTTGGAGCAAGACAAATGATGCTGGGTCGGACAGAGTGATGGTGTCTCCC
CTAGCTGTAACTTGGTGGAACAGGAATGGGCCGACAACAAGTACAGTCCATTATCCAAAGGTTTACAAAA
CATACTTTGAGAAGGTTGAAAGGTTAAAACATGGAACCTTCGGTCCCGTTCATTTCCGAAACCAAGTTAA
AATACGTCGCCGGGTGGATATAAACCCGGGCCATGCAGATCTCAGTGCTAAAGAAGCACAAGATGTTATC
ATGGAGGTCGTTTTCCCAAATGAAGTGGGAGCTAGAATATTGACATCAGAGTCGCAATTGACAATAACAA
AAGAGAAGAAAGAAGAGCTCCAGGATTGTAAAATTGCTCCTTTAATGGTGGCATACATGTTGGAAAGAGA
ACTGGTCCGCAAAACCAGATTTCTACCGGTAGCAGGCGGAACAAGCAGTGTGTACATTGAGGTATTGCAT
TTGACTCAAGGGACCTGTTGGGAACAGATGTACACTCCCGGCGGAGAAGTAAGAAATGATGATGTTGACC
AGAGTTTGATCATCGCTGCCAGAAACATTGTTAGGAGAGCAACAGTATCAGCGGACCCACTGGCATCACT
CTTGGAGATGTGTCACAGCACACAAATTGGGGGAATAAGGATGGTGGACATCCTTAGGCAAAACCCAACT
GAGGAGCAAGCTGTGGATATATGCAAAGCAGCAATGGGTTTGAGGATCAGTTCATCCTTTAGCTTTGGAG
GCTTCACTTTCAAAAGAACAAATGGATCATCCGTCAAGAAGGAAGAGGAAGTGCTTACAGGCAACCTCCA
AACATTGAAAATAAAAGTACATGAGGGGTATGAAGAATTCACAATGGTTGGGCGGAGAGCAACAGCTATC
CTGAGGAAAGCAACTAGAAGGCTGATTCAGTTGATAGTAAGTGGAAGAGATGAACAATCAATCGCTGAAG
CGATCATTGTAGCAATGGTGTTCTCACAGGAGGATTGCATGATAAAGGCAGTCCGAGGCGATCTGAATTT
CGTGAACAGAGCAAACCAAAGATTGAACCCCATGCATCAACTCCTGAGGCACTTCCAAAAAGATGCAAAA
GTGCTGTTTCAGAACTGGGGAATTGAACCTATTGACAATGTCATGGGGATGATCGGAATATTACCTGACA
TGACTCCAAGCGCAGAGATGTCACTGAGAGGAGTGAGAGTTAGTAAGATGGGAGTAGATGAATATTCCAG
CACGGAGAGAGTGGTGGTGAGTATTGACCGTTTCTTGAGGGTCCGAGATCAGCAGGGGAACGTACTCTTA
TCTCCTGAAGAGGTTAGTGAAACACAGGGAACAGAGAAGTTGACAATAACATATTCATCCTCAATGATGT
GGGAAATCAACGGTCCTGAGTCAGTGCTTGTTAACACTTATCAATGGATCATCAGGAATTGGGAGACTGT
AAAGATTCAATGGTCTCAAGATCCCACAATGCTGTACAATAAGATGGAGTTTGAATCGTTCCAATCCTTG
GTGCCAAAGGCTGCCAGAAGCCAATATAGTGGATTTGTGAGAACACTATTCCAACAGATGCGTGATGTTT
TGGGGACATTTGATACTGTCCAAATAATCAAGCTGCTACCATTTGCAGCAGCCCCACCGGAGCCGAGCAG
AATGCAGTTTTCTTCTCTAACTGTGAATGTGAGAGGCTCAGGAATGAGAATACTCGTGAGGGGTAACTCC
CCCGTGTTCAACTACAACAAGGCAACCAAAAGGCTTACAGTCCTCGGAAAGGACGCAGGTGCATTAACAG
AAGATCCAGACGAGGGAACAGCCGGGGTGGAATCTGCAGTATTGAGGGGATTCCTAATTCTAGGCAGAGA
GGACAAAAGATATGGACCCGCATTGAGCATCAATGAACTGAGCAATCTTGCAAAAGGGGAGAAGGCTAAT
GTATTGATAATGCAAGGAGACGTGGTGTTGGTAATGAAACGGAAACGGGACTTTAGCATACTTACTGACA
GCCAGACAGCGACCAAAAGAATTCGGATGGCCATCAATTA
Protein Sequence 
>gi|73852947|ref|YP_308664.1| polymerase PB2 [Influenza A virus (A/goose/Guangdong/1/1996(H5N1))]
MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIMEMIPER
NEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVK
IRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKIAPLMVAYMLERE
LVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRATVSADPLASL
LEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTNGSSVKKEEEVLTGNLQ
TLKIKVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNF
VNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMIGILPDMTPSAEMSLRGVRVSKMGVDEYSS
TERVVVSIDRFLRVRDQQGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETV
KIQWSQDPTMLYNKMEFESFQSLVPKAARSQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEPSR
MQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTAGVESAVLRGFLILGRE
DKRYGPALSINELSNLAKGEKANVLIMQGDVVLVMKRKRDFSILTDSQTATKRIRMAIN
Molecule Role Virulence factor
Molecule Role Annotation The recombinant viruses with the PB2 (63T) mutation were less pathogenic to mice. (Li et al., 2011)
References
Li et al., 2011: Li J, Li Y, Hu Y, Chang G, Sun W, Yang Y, Kang X, Wu X, Zhu Q. PB1-mediated virulence attenuation of H5N1 influenza virus in mice is associated with PB2. The Journal of general virology. 2011; 92(Pt 6); 1435-1444. [PubMed: 21367983].