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Victors Search
Found 3 gene(s).
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| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
vif |
Human immunodeficiency virus |
155459
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9629361
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HIV1gp3 |
|
NP_057851.1 |
p23 |
Virulence factor |
MUTATION: A mutation in the vif gene reduces viral replication and infectivity in nonpermissive cells [Ref6606:Farrow et al., 2005]. |
15989462
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vpr |
Human immunodeficiency virus |
155807
|
|
28872817
|
HIV1gp4 |
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NP_057852.2 |
p15 |
Virulence factor |
MUTATION: T cell infections using vesicular stomatitis virus G (VSV-G) pseudotyped HIV-1 Vpr R77Q result in less (P = 0.01) T cell death than infections using wild-type Vpr, despite similar levels of viral replication. Wild-type Vpr-associated events, including procaspase-8 and -3 cleavage, loss of mitochondrial transmembrane potential (deltapsi(m)), and DNA fragmentation factor activation are attenuated by R77Q Vpr. There is also a higher frequency of R77Q Vpr mutations in patients with LTNP than in patients with progressive disease [Ref6607:Lum et al., 2003]. |
12750404
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nef |
Human immunodeficiency virus |
156110
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28872818
|
HIV1gp9 |
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NP_057857.2 |
p27 |
Virulence factor |
MUTATION: HIV-1 replication in vivo can be separated from its pathogenic activity, in that the HXB/LW virus replicated to high levels in SCID-hu Thy/Liv mice, with no significant thymocyte depletion. Restoration of the nef gene in the recombinant HXB/LW genome restored its pathogenic activity, with no significant effect on HIV-1 replication in the thymus. Implicating nef as a determinant of pathogenicity [Ref6608:Duus et al., 2001]. |
11264380
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