Protegen ID	Gene Name	Sequence Strain (Species/Organism)	NCBI Gene ID	NCBI Nucleotide GI	NCBI Protein GI	Locus Tag	Genbank Accession	Protein Accession	Protein Name	Protein Annotation	Molecule Role	Molecule Role Annotation	COG	PMID
1918	vif	Human immunodeficiency virus	155459		9629361	HIV1gp3		NP_057851.1	p23		Virulence factor	MUTATION: A mutation in the vif gene reduces viral replication and infectivity in nonpermissive cells [Ref6606:Farrow et al., 2005].		15989462
1919	vpr	Human immunodeficiency virus	155807		28872817	HIV1gp4		NP_057852.2	p15		Virulence factor	MUTATION: T cell infections using vesicular stomatitis virus G (VSV-G) pseudotyped HIV-1 Vpr R77Q result in less (P = 0.01) T cell death than infections using wild-type Vpr, despite similar levels of viral replication. Wild-type Vpr-associated events, including procaspase-8 and -3 cleavage, loss of mitochondrial transmembrane potential (deltapsi(m)), and DNA fragmentation factor activation are attenuated by R77Q Vpr. There is also a higher frequency of R77Q Vpr mutations in patients with LTNP than in patients with progressive disease [Ref6607:Lum et al., 2003].		12750404
1920	nef	Human immunodeficiency virus	156110		28872818	HIV1gp9		NP_057857.2	p27		Virulence factor	MUTATION: HIV-1 replication in vivo can be separated from its pathogenic activity, in that the HXB/LW virus replicated to high levels in SCID-hu Thy/Liv mice, with no significant thymocyte depletion. Restoration of the nef gene in the recombinant HXB/LW genome restored its pathogenic activity, with no significant effect on HIV-1 replication in the thymus. Implicating nef as a determinant of pathogenicity [Ref6608:Duus et al., 2001].		11264380