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nef

Victor ID 1920
Gene Name nef
Sequence Strain (Species/Organism) Human immunodeficiency virus
NCBI Gene ID 156110
NCBI Protein GI 28872818
Locus Tag HIV1gp9
Protein Accession NP_057857.2
Other Database IDs UniProtKB-ID: NEF_HV1H2
UniRef100: UniRef100_P04601
UniRef90: UniRef90_P05854
UniRef50: UniRef50_P05857
UniParc: UPI0000167FEC
EMBL: X03187
EMBL: K03455
EMBL: AF033819
EMBL-CDS: CAA26946.1
EMBL-CDS: AAB50263.1
EMBL-CDS: AAC82597.1
RefSeq_NT: NC_001802.1
Reactome: REACT_6185
Taxonomy ID 11676
Gene Starting Position 8342
Gene Ending Position 8962
Gene Strand (Orientation) +
Protein Name p27
DNA Sequence 
>gi|9629357:8342-8962 Human immunodeficiency virus 1, complete genome
GATGGGTGGCAAGTGGTCAAAAAGTAGTGTGATTGGATGGCCTACTGTAAGGGAAAGAATGAGACGAGCT
GAGCCAGCAGCAGATAGGGTGGGAGCAGCATCTCGAGACCTGGAAAAACATGGAGCAATCACAAGTAGCA
ATACAGCAGCTACCAATGCTGCTTGTGCCTGGCTAGAAGCACAAGAGGAGGAGGAGGTGGGTTTTCCAGT
CACACCTCAGGTACCTTTAAGACCAATGACTTACAAGGCAGCTGTAGATCTTAGCCACTTTTTAAAAGAA
AAGGGGGGACTGGAAGGGCTAATTCACTCCCAAAGAAGACAAGATATCCTTGATCTGTGGATCTACCACA
CACAAGGCTACTTCCCTGATTAGCAGAACTACACACCAGGGCCAGGGGTCAGATATCCACTGACCTTTGG
ATGGTGCTACAAGCTAGTACCAGTTGAGCCAGATAAGATAGAAGAGGCCAATAAAGGAGAGAACACCAGC
TTGTTACACCCTGTGAGCCTGCATGGGATGGATGACCCGGAGAGAGAAGTGTTAGAGTGGAGGTTTGACA
GCCGCCTAGCATTTCATCACGTGGCCCGAGAGCTGCATCCGGAGTACTTCAAGAACTGCTG
Protein Sequence 
>gi|28872818|ref|NP_057857.2| Nef [Human immunodeficiency virus 1] MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: HIV-1 replication in vivo can be separated from its pathogenic activity, in that the HXB/LW virus replicated to high levels in SCID-hu Thy/Liv mice, with no significant thymocyte depletion. Restoration of the nef gene in the recombinant HXB/LW genome restored its pathogenic activity, with no significant effect on HIV-1 replication in the thymus. Implicating nef as a determinant of pathogenicity (Duus et al., 2001).
References
Duus et al., 2001: Duus KM, Miller ED, Smith JA, Kovalev GI, Su L. Separation of human immunodeficiency virus type 1 replication from nef-mediated pathogenesis in the human thymus. Journal of virology. 2001; 75(8); 3916-3924. [PubMed: 11264380].