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vpr

Victor ID 1919
Gene Name vpr
Sequence Strain (Species/Organism) Human immunodeficiency virus
NCBI Gene ID 155807
NCBI Protein GI 28872817
Locus Tag HIV1gp4
Protein Accession NP_057852.2
Other Database IDs UniProtKB-ID: Q77YF9_9HIV1
UniRef100: UniRef100_P69728
UniRef90: UniRef90_P69728
UniRef50: UniRef50_Q8AII0
UniParc: UPI00000134EE
EMBL: AF033819
EMBL: DQ167216
EMBL-CDS: AAC82595.1
EMBL-CDS: AAZ95230.1
RefSeq_NT: NC_001802.1
HSSP: P12520
Taxonomy ID 11676
Gene Starting Position 5104
Gene Ending Position 5395
Gene Strand (Orientation) +
Protein Name p15
DNA Sequence 
>gi|9629357:5104-5395 Human immunodeficiency virus 1, complete genome
GATGGAACAAGCCCCAGAAGACCAAGGGCCACAGAGGGAGCCACACAATGAATGGACACTAGAGCTTTTA
GAGGAGCTTAAGAATGAAGCTGTTAGACATTTTCCTAGGATTTGGCTCCATGGCTTAGGGCAACATATCT
ATGAAACTTATGGGGATACTTGGGCAGGAGTGGAAGCCATAATAAGAATTCTGCAACAACTGCTGTTTAT
CCATTTTCAGAATTGGGTGTCGACATAGCAGAATAGGCGTTACTCGACAGAGGAGAGCAAGAAATGGAGC
CAGTAGATCCTA
Protein Sequence 
>gi|28872817|ref|NP_057852.2| Vpr [Human immunodeficiency virus 1] MEQAPEDQGPQREPHNEWTLELLEELKNEAVRHFPRIWLHGLGQHIYETYGDTWAGVEAIIRILQQLLFIHFRIGCRHSRIGVTRQRRARNGASRS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: T cell infections using vesicular stomatitis virus G (VSV-G) pseudotyped HIV-1 Vpr R77Q result in less (P = 0.01) T cell death than infections using wild-type Vpr, despite similar levels of viral replication. Wild-type Vpr-associated events, including procaspase-8 and -3 cleavage, loss of mitochondrial transmembrane potential (deltapsi(m)), and DNA fragmentation factor activation are attenuated by R77Q Vpr. There is also a higher frequency of R77Q Vpr mutations in patients with LTNP than in patients with progressive disease (Lum et al., 2003).
References
Lum et al., 2003: Lum JJ, Cohen OJ, Nie Z, Weaver JG, Gomez TS, Yao XJ, Lynch D, Pilon AA, Hawley N, Kim JE, Chen Z, Montpetit M, Sanchez-Dardon J, Cohen EA, Badley AD. Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis. The Journal of clinical investigation. 2003; 111(10); 1547-1554. [PubMed: 12750404].