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Victors Search
Found 2 gene(s).
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| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
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RRVgp2 |
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1489707
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envelope glycoprotein E2 |
Virulence factor |
In day-old mice, RRV dE2,with a 21-nucleotide deletion in the gene coding for the envelope glycoprotein E2, induced less severe symptoms of hind leg paralysis than did RRV T48. In week-old mice, RRV dE2 induced no detectable symptoms even when injected at high doses. [Ref7427:Vrati et al., 1986] |
3010551
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nsP1 |
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25121492
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nsP1 protein |
Virulence factor |
we identify two nonsynonymous nucleotide changes as sufficient for the attenuated phenotype. RRV T48 carrying the six nonsynonymous DC5692 nucleotide differences (RRV-T48-nsP1(6M)) was attenuated in both wild-type and Rag1(-/-) mice. Despite the attenuated phenotype, RRV T48 and RRV-T48-nsP1(6M) loads in tissues of wild-type and Rag1(-/-) mice were indistinguishable from 1 to 3 days postinoculation. RRV-T48-nsP1(6M) loads in skeletal muscle tissue, but not in other tissues, decreased dramatically by 5 days postinoculation in both wild-type and Rag1(-/-) mice, suggesting that the RRV-T48-nsP1(6M) mutant is more sensitive to innate antiviral effectors than RRV T48 in a tissue-specific manner.
[Ref7488:Stoermer et al., 2014] |
24429363
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