Protegen ID	Gene Name	Sequence Strain (Species/Organism)	NCBI Gene ID	NCBI Nucleotide GI	NCBI Protein GI	Locus Tag	Genbank Accession	Protein Accession	Protein Name	Protein Annotation	Molecule Role	Molecule Role Annotation	COG	PMID
5022	RRVgp2		1489707						envelope glycoprotein E2		Virulence factor	In day-old mice, RRV dE2,with a 21-nucleotide deletion in the gene coding for the envelope glycoprotein E2, induced less severe symptoms of hind leg paralysis than did RRV T48. In week-old mice, RRV dE2 induced no detectable symptoms even when injected at high doses.  [Ref7427:Vrati et al., 1986]		3010551
5023	RRVgp2													
5087	nsP1				25121492				nsP1 protein		Virulence factor	we identify two nonsynonymous nucleotide changes as sufficient for the attenuated phenotype. RRV T48 carrying the six nonsynonymous DC5692 nucleotide differences (RRV-T48-nsP1(6M)) was attenuated in both wild-type and Rag1(-/-) mice. Despite the attenuated phenotype, RRV T48 and RRV-T48-nsP1(6M) loads in tissues of wild-type and Rag1(-/-) mice were indistinguishable from 1 to 3 days postinoculation. RRV-T48-nsP1(6M) loads in skeletal muscle tissue, but not in other tissues, decreased dramatically by 5 days postinoculation in both wild-type and Rag1(-/-) mice, suggesting that the RRV-T48-nsP1(6M) mutant is more sensitive to innate antiviral effectors than RRV T48 in a tissue-specific manner. ; [Ref7488:Stoermer et al., 2014]		24429363