| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
lpg0742 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3078198
|
|
52840979
|
lpg0742 |
AE017354 |
YP_094778 |
hypothetical protein |
Virulence factor |
MUTATION: ldsA (lpg0742) mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
cpxR from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3078361
|
|
52841668
|
lpg1438 |
|
YP_095467.1 |
transcriptional regulatory protein CpxR |
Virulence factor |
MUTATION: cpxR mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
mip from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3078495
|
|
52841028
|
lpg0791 |
|
YP_094827.1 |
macrophage infectivity potentiator (Mip) |
Virulence factor |
MUTATION: mip mutants are approximately 50- to 100-fold less infective for A. castellanii and for human mononuclear phagocytes in vitro compared with their isogenic Mip-positive parental strains [Ref6564:Wintermeyer et al., 1995]. |
7591108
|
|
|
lpg1905 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3078951
|
|
52842123
|
lpg1905 |
AE017354 |
YP_095922 |
ectonucleoside triphosphate diphosphohydrolase I |
Virulence factor |
MUTATION: lpg1905 mutant is attenuated in macrophages and human alveolar cells [Ref6565:Sansom et al., 2007]. |
17388784
|
|
|
lpg2155 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3078981
|
|
52842369
|
lpg2155 |
AE017354 |
YP_096168 |
hypothetical protein |
Virulence factor |
MUTATION: sidJ (lpg2155) mutant is attenuated in macrophages [Ref6566:Liu and Luo, 2007]. |
17101649
|
|
|
icmX from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3079093
|
|
52842895
|
lpg2689 |
|
YP_096694.1 |
IcmX (IcmY) |
Virulence factor |
MUTATION: icmX mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
enhC |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3079177
|
|
52842845
|
lpg2639 |
AE017354 |
YP_096644 |
enhanced entry protein EnhC |
Virulence factor |
MUTATION: enhC mutant is attenuated in mouse macrophages [Ref6568:Liu et al., 2008]. |
18549456
|
|
|
dotB from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3079449
|
|
52842882
|
lpg2676 |
|
YP_096681.1 |
DotB |
Virulence factor |
MUTATION: dotB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
dotA from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3079451
|
|
52842892
|
lpg2686 |
|
YP_096691.1 |
DotA |
Virulence factor |
MUTATION: dotA mutant is unable to replicate in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
feoB from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3079487
|
|
52842863
|
lpg2657 |
|
YP_096662.1 |
ferrous iron transporter B |
Virulence factor |
MUTATION: feoB mutant is attenuated in human macrophages [Ref6569:Robey and Cianciotto, 2002]. |
12228295
|
|
|
ptsP from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3079830
|
|
52843066
|
lpg2871 |
|
YP_096865.1 |
phosphoenolpyruvate protein phosphotransferase PtsP |
Virulence factor |
MUTATION: ptsP mutant is attenuated in guinea pigs [Ref6570:Higa and Edelstein, 2001]. |
11447151
|
|
|
icmG from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3079958
|
|
52840697
|
lpg0452 |
|
YP_094496.1 |
IcmG (DotF) |
Virulence factor |
MUTATION: icmG mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
icmB from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3080126
|
|
52840701
|
lpg0456 |
|
YP_094500.1 |
IcmB (DotO) |
Virulence factor |
MUTATION: icmB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
rpoS from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3080381
|
|
52841515
|
lpg1284 |
|
YP_095314.1 |
stationary phase specific sigma factor RpoS |
Virulence factor |
MUTATION: rpoS mutant is defective in intracellular replication in its protozoan host [Ref6571:Hovel-Miner et al., 2009]. |
19218380
|
|
|
djlA from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3080541
|
|
52842551
|
lpg2341 |
|
YP_096350.1 |
Dna-J like membrane chaperone protein |
Virulence factor |
MUTATION: djlA mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
lpg2515 |
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
3080592
|
|
52842723
|
lpg2515 |
AE017354 |
YP_096522 |
structural toxin protein (hemagglutinin/hemolysin) RtxA |
Virulence factor |
MUTATION: rtxA mutant is attenuated in mice and does not replicate as well as the wild type in monocytes [Ref6572:Cirillo et al., 2001]. |
11119544
|
|
|
plaB from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3113555
|
|
54294354
|
lpl1422 |
|
YP_126769.1 |
phospholipase |
Virulence factor |
MUTATION: plaB mutant is attenuated in guinea pigs [Ref6574:Schunder et al., 2010]. |
20153694
|
|
|
ptsP from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3113668
|
|
54295696
|
lpl2784 |
|
YP_128111.1 |
phosphoenolpyruvate-protein phosphotransferase PtsP |
Virulence factor |
MUTATION: ptsP mutant is attenuated in guinea pigs [Ref6570:Higa and Edelstein, 2001]. |
11447151
|
|
|
dotA from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3113684
|
|
54295526
|
lpl2613 |
|
YP_127941.1 |
defect in organelle trafficking protein DotA |
Virulence factor |
MUTATION: dotA mutant is unable to replicate in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
djlA from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3113813
|
|
54295182
|
lpl2262 |
|
YP_127597.1 |
Dna-J like membrane chaperone protein |
Virulence factor |
MUTATION: djlA mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
icmX from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3114023
|
|
54295529
|
lpl2616 |
|
YP_127944.1 |
Intracellular multiplication protein IcmX |
Virulence factor |
MUTATION: icmX mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
rtxA-2 |
Legionella pneumophila str. Lens |
3114223
|
|
54293628
|
lpl0681 |
CR628337 |
YP_126043 |
structural toxin protein RtxA |
Virulence factor |
MUTATION: rtxA mutant is attenuated in mice and doesn't grow as well in monocytes as the wild type [Ref6572:Cirillo et al., 2001]. |
11119544
|
|
|
mip from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3114458
|
|
54293773
|
lpl0829 |
|
YP_126188.1 |
macrophage infectivity potentiator |
Virulence factor |
MUTATION: mip mutants are approximately 50- to 100-fold less infective for A. castellanii and for human mononuclear phagocytes in vitro compared with their isogenic Mip-positive parental strains [Ref6564:Wintermeyer et al., 1995]. |
7591108
|
|
|
flaA from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3114487
|
|
54294228
|
lpl1293 |
|
YP_126643.1 |
flagellin |
Virulence factor |
MUTATION: flaA mutant is less invasive of HL-60 cells than the wild type [Ref6575:Dietrich et al., 2001]. |
11254565
|
|
|
fur from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3114575
|
|
54293365
|
lpl0414 |
|
YP_125780.1 |
Ferric uptake regulation protein |
Virulence factor |
MUTATION: fur mutant has attenuated intracellular growth within U937 cell monolayers [Ref6569:Robey and Cianciotto, 2002]. |
12228295
|
|
|
sdhA from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3114696
|
|
54293370
|
lpl0419 |
|
YP_125785.1 |
SdhA, substrate of the Dot/Icm system |
Virulence factor |
MUTATION: sdhA mutant is attenuated in mouse macrophages [Ref6576:Laguna et al., 2006]. |
17124169
|
|
|
dotB from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3114737
|
|
54295516
|
lpl2603 |
|
YP_127931.1 |
defect in organelle trafficking protein DotB (ATPase) |
Virulence factor |
MUTATION: dotB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
iraA from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3114746
|
|
54293731
|
lpl0784 |
|
YP_126146.1 |
small-molecule methyltransferase IraA |
Virulence factor |
MUTATION: iraA mutant is attenuated in guinea pigs [Ref6577:Viswanathan et al., 2000]. |
10678909
|
|
|
rpoS from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3114978
|
|
54294183
|
lpl1247 |
|
YP_126598.1 |
RNA polymerase sigma factor RpoS |
Virulence factor |
MUTATION: rpoS mutant is defective in intracellular replication in its protozoan host [Ref6571:Hovel-Miner et al., 2009]. |
19218380
|
|
|
lvgA from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3115099
|
|
54293520
|
lpl0571 |
|
YP_125935.1 |
hypothetical protein |
Virulence factor |
MUTATION: lvgA mutant is attenuated in guinea pigs [Ref6578:Edelstein et al., 2003]. |
12704109
|
|
|
cpxR from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3115566
|
|
54294527
|
lpl1603 |
|
YP_126942.1 |
transcriptional regulatory protein CpxR |
Virulence factor |
MUTATION: cpxR mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
feoB from Legionella pneumophila str. Lens |
Legionella pneumophila str. Lens |
3115599
|
|
54295497
|
lpl2584 |
|
YP_127912.1 |
ferrous iron transporter B |
Virulence factor |
MUTATION: feoB mutant is attenuated in human macrophages [Ref6569:Robey and Cianciotto, 2002]. |
12228295
|
|
|
plaB from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3116520
|
|
54297520
|
lpp1568 |
|
YP_123889.1 |
phospholipase |
Virulence factor |
MUTATION: plaB mutant is attenuated in guinea pigs [Ref6574:Schunder et al., 2010]. |
20153694
|
|
|
iraA from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3116645
|
|
54296774
|
lpp0813 |
|
YP_123143.1 |
small-molecule methyltransferase IraA |
Virulence factor |
MUTATION: iraA mutant is attenuated in guinea pigs [Ref6577:Viswanathan et al., 2000]. |
10678909
|
|
|
lvgA from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3116728
|
|
54296559
|
lpp0590 |
|
YP_122928.1 |
hypothetical protein |
Virulence factor |
MUTATION: lvgA mutant is attenuated in guinea pigs [Ref6578:Edelstein et al., 2003]. |
12704109
|
|
|
rpoS from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3117391
|
|
54297202
|
lpp1247 |
|
YP_123571.1 |
RNA polymerase sigma factor RpoS |
Virulence factor |
MUTATION: rpoS mutant has defective intracellular replication in its protozoan host [Ref6571:Hovel-Miner et al., 2009]. |
19218380
|
|
|
rtxA-1 |
Legionella pneumophila str. Paris |
3117483
|
|
54296668
|
lpp0699 |
CR628336 |
YP_123037 |
structural toxin protein RtxA |
Virulence factor |
MUTATION: rtxA mutant is attenuated in mice and doesn't grow as well in monocytes as the wild type [Ref6572:Cirillo et al., 2001]. |
11119544
|
|
|
sdhA from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3117748
|
|
54296413
|
lpp0443 |
|
YP_122782.1 |
SdhA, substrate of the Dot/Icm system |
Virulence factor |
MUTATION: sdhA mutant is attenuated in mouse macrophages [Ref6576:Laguna et al., 2006]. |
17124169
|
|
|
dotA from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3117985
|
|
54298676
|
lpp2740 |
|
YP_125045.1 |
defect in organelle trafficking protein DotA |
Virulence factor |
MUTATION: dotA mutant is unable to replicate in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
dotB from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3117986
|
|
54298666
|
lpp2730 |
|
YP_125035.1 |
defect in organelle trafficking protein DotB (ATPase) |
Virulence factor |
MUTATION: dotB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
icmX from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3118177
|
|
54298679
|
lpp2743 |
|
YP_125048.1 |
Intracellular multiplication protein IcmX |
Virulence factor |
MUTATION: icmX mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
cpxR from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3118718
|
|
54297348
|
lpp1393 |
|
YP_123717.1 |
transcriptional regulatory protein CpxR |
Virulence factor |
MUTATION: cpxR mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
ptsP from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3118937
|
|
54298863
|
lpp2930 |
|
YP_125232.1 |
phosphoenolpyruvate-protein phosphotransferase PtsP |
Virulence factor |
MUTATION: ptsP mutant is attenuated in guinea pigs [Ref6570:Higa and Edelstein, 2001]. |
11447151
|
|
|
fur from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3119216
|
|
54296409
|
lpp0438 |
|
YP_122778.1 |
Ferric uptake regulation protein |
Virulence factor |
MUTATION: fur mutant is attenuated in growth within U937 cell monolayers[Ref6579:Hickey and Cianciotto, 1997]. |
8975903
|
|
|
mip from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3119248
|
|
54296815
|
lpp0855 |
|
YP_123184.1 |
macrophage infectivity potentiator |
Virulence factor |
MUTATION: mip mutants are approximately 50- to 100-fold less infective for A. castellanii and for human mononuclear phagocytes in vitro compared with their isogenic Mip-positive parental strains [Ref6564:Wintermeyer et al., 1995]. |
7591108
|
|
|
feoB from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3119310
|
|
54298647
|
lpp2711 |
|
YP_125016.1 |
ferrous iron transporter B |
Virulence factor |
MUTATION: feoB mutant is attenuated in human macrophages [Ref6569:Robey and Cianciotto, 2002]. |
12228295
|
|
|
flaA from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3119334
|
|
54297249
|
lpp1294 |
|
YP_123618.1 |
flagellin |
Virulence factor |
MUTATION: flaA mutant is less invasive of HL-60 cells than the wild type [Ref6575:Dietrich et al., 2001]. |
11254565
|
|
|
djlA from Legionella pneumophila str. Paris |
Legionella pneumophila str. Paris |
3119498
|
|
54298231
|
lpp2289 |
|
YP_124600.1 |
Dna-J like membrane chaperone protein |
Virulence factor |
MUTATION: djlA mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
mip from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5180329
|
|
148360557
|
LPC_2500 |
|
YP_001251764.1 |
macrophage infectivity potentiator (Mip) |
Virulence factor |
MUTATION: mip mutants are approximately 50- to 100-fold less infective for A. castellanii and for human mononuclear phagocytes in vitro compared with their isogenic Mip-positive parental strains [Ref6564:Wintermeyer et al., 1995]. |
7591108
|
|
|
iraA from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5180371
|
|
148360599
|
LPC_2545 |
|
YP_001251806.1 |
small-molecule methyltransferase IraA |
Virulence factor |
MUTATION: iraA mutant is attenuated in guinea pigs [Ref6577:Viswanathan et al., 2000]. |
10678909
|
|
|
rpoS from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5180541
|
|
148358826
|
LPC_0709 |
|
YP_001250033.1 |
stationary phase specific sigma factor RpoS |
Virulence factor |
MUTATION: rpoS mutant has defective intracellular replication in its protozoan host [Ref6571:Hovel-Miner et al., 2009]. |
19218380
|
|
|
cpxR from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5180685
|
|
148358969
|
LPC_0854 |
|
YP_001250176.1 |
transcriptional regulatory protein CpxR |
Virulence factor |
MUTATION: cpxR mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
plaB from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5180855
|
|
148359137
|
LPC_1029 |
|
YP_001250344.1 |
phospholipase |
Virulence factor |
MUTATION: plaB mutant is attenuated in guinea pigs [Ref6574:Schunder et al., 2010]. |
20153694
|
|
|
djlA from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5181617
|
|
148359881
|
LPC_1809 |
|
YP_001251088.1 |
Dna-J like membrane chaperone protein |
Virulence factor |
MUTATION: djlA mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
icmX from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5182246
|
|
148358575
|
LPC_0447 |
|
YP_001249782.1 |
Intracellular multiplication protein IcmX |
Virulence factor |
MUTATION: icmX mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
dotA from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5182249
|
|
148358578
|
LPC_0450 |
|
YP_001249785.1 |
defect in organelle trafficking protein DotA |
Virulence factor |
MUTATION: dotA mutant is unable to replicate in mouse macrophages [Ref6563:Vincent et al., 2006]. |
16997951
|
|
|
dotB from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5182260
|
|
148358589
|
LPC_0461 |
|
YP_001249796.1 |
defect in organelle trafficking protein DotB (ATPase) |
Virulence factor |
MUTATION: dotB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
feoB from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5182279
|
|
148358608
|
LPC_0482 |
|
YP_001249815.1 |
ferrous iron transporter B |
Virulence factor |
MUTATION: feoB mutant is attenuated in human macrophages [Ref6569:Robey and Cianciotto, 2002]. |
12228295
|
|
|
lvgA from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5182556
|
|
148360819
|
LPC_2777 |
|
YP_001252026.1 |
hypothetical virulence protein |
Virulence factor |
MUTATION: lvgA mutant is attenuated in guinea pigs [Ref6578:Edelstein et al., 2003]. |
12704109
|
|
|
icmB from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5182665
|
|
148360927
|
LPC_2887 |
|
YP_001252134.1 |
IcmB (DotO) |
Virulence factor |
MUTATION: icmB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
icmG from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5182669
|
|
148360931
|
LPC_2891 |
|
YP_001252138.1 |
IcmG (DotF) |
Virulence factor |
MUTATION: icmG mutant is attenuated in mice [Ref6567:Edelstein et al., 1999]. |
10393970
|
|
|
fur from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5182750
|
|
148361012
|
LPC_2972 |
|
YP_001252219.1 |
Ferric uptake regulation protein |
Virulence factor |
MUTATION: fur mutant is attenuated in growth within U937 cell monolayers [Ref6579:Hickey and Cianciotto, 1997]. |
8975903
|
|
|
ptsP from Legionella pneumophila str. Corby |
Legionella pneumophila str. Corby |
5182932
|
|
148361183
|
LPC_3157 |
|
YP_001252390.1 |
phosphoenolpyruvate protein phosphotransferase PtsP |
Virulence factor |
MUTATION: ptsP mutant is attenuated in guinea pigs [Ref6570:Higa and Edelstein, 2001]. |
11447151
|
|
|
lpa_03874 |
Legionella pneumophila 2300/99 Alcoy |
9130593
|
|
296108291
|
lpa_03874 |
CP001828 |
YP_003619992 |
Legionella transmission activator LetA |
Virulence factor |
MUTATION: letA mutant is non-motile and is attenuated for infecting murine macrophages [Ref6902:Hammer et al., 2002]. |
11967072
|
|
|
katB |
Legionella pneumophila |
|
3764089
|
|
|
|
|
|
Virulence factor |
MUTATION: katB mutant is delayed in the infection and lysis of cultured macrophage-like cell lines
[Ref6996:Bandyopadhyay and Steinman, 1998]. |
9765568
|
|
|
lbtA |
Legionella pneumophila 130b |
|
71726458
|
71726459
|
|
|
AAZ39407.1 |
legiobactin biosynthesis protein A |
Virulence factor |
MUTATION: lbtA mutant displayed a reduced ability to infect the lungs of A/J mice after intratracheal inoculation
[Ref6997:Allard et al., 2009]. |
19398549
|
|
|
milA |
Legionella pneumophila AA100 |
|
5702298
|
5702299
|
|
|
AAD47247.1 |
putative transport protein |
Virulence factor |
MUTATION: milA mutant is defective in intracellular replication in macrophages [Ref6998:Harb and Abu, 2000]. |
10603410
|
|
|
LPS |
Legionella pneumophila |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: mutant 811 (an LPS mutant) has reduced ability to replicate in guinea pigs and is not serum resistant [Ref7292:Lüneberg et al., 1998]. |
9653083
|
|
|
tolC |
Legionella pneumophila str. Lens |
3114064
|
|
54293683
|
lpl0736 |
CR628337 |
YP_126098 |
hypothetical protein |
Virulence factor |
Deletion of tolC by allelic exchange in L. pneumophila caused increased sensitivity to various drugs. The complementation of the tolC mutation in trans restored drug resistance, indicating that TolC is involved in multi-drug efflux machinery. In addition, deletion of tolC caused a significant attenuation of virulence towards both amoebae and macrophages.[Ref7592:Ferhat et al., 2009]
|
19888467
|
|
|
iraA |
Legionella pneumophila str. Paris |
3116645
|
|
54296774
|
lpp0813 |
CR628336 |
YP_123143 |
small-molecule methyltransferase IraA |
Virulence factor |
NU216R-infected animals yielded 1,000-fold fewer bacteria from their lungs and spleen compared to wild-type-130b-infected animals that had received a 50-fold-lower dose. Moreover, NU216R-infected animals subsequently cleared the bacteria from these sites.[Ref6577:Viswanathan et al., 2000]
|
10678909
|
