Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 1435 lpg0742 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3078198 52840979 lpg0742 AE017354 YP_094778 hypothetical protein Virulence factor MUTATION: ldsA (lpg0742) mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. 16997951 1436 cpxR from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3078361 52841668 lpg1438 YP_095467.1 transcriptional regulatory protein CpxR Virulence factor MUTATION: cpxR mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 16997951 1437 mip from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3078495 52841028 lpg0791 YP_094827.1 macrophage infectivity potentiator (Mip) Virulence factor MUTATION: mip mutants are approximately 50- to 100-fold less infective for A. castellanii and for human mononuclear phagocytes in vitro compared with their isogenic Mip-positive parental strains [Ref6564:Wintermeyer et al., 1995]. COG0545O, under O: Posttranslational modification, protein turnover, chaperones 7591108 1438 lpg1905 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3078951 52842123 lpg1905 AE017354 YP_095922 ectonucleoside triphosphate diphosphohydrolase I Virulence factor MUTATION: lpg1905 mutant is attenuated in macrophages and human alveolar cells [Ref6565:Sansom et al., 2007]. COG5371GO, under G: Carbohydrate transport and metabolism; O: Posttranslational modification, protein turnover, chaperones 17388784 1439 lpg2155 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3078981 52842369 lpg2155 AE017354 YP_096168 hypothetical protein Virulence factor MUTATION: sidJ (lpg2155) mutant is attenuated in macrophages [Ref6566:Liu and Luo, 2007]. 17101649 1440 icmX from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3079093 52842895 lpg2689 YP_096694.1 IcmX (IcmY) Virulence factor MUTATION: icmX mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. 10393970 1441 enhC Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3079177 52842845 lpg2639 AE017354 YP_096644 enhanced entry protein EnhC Virulence factor MUTATION: enhC mutant is attenuated in mouse macrophages [Ref6568:Liu et al., 2008]. COG0790R, under R: General function prediction only 18549456 1442 dotB from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3079449 52842882 lpg2676 YP_096681.1 DotB Virulence factor MUTATION: dotB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. COG2805NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 10393970 1443 dotA from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3079451 52842892 lpg2686 YP_096691.1 DotA Virulence factor MUTATION: dotA mutant is unable to replicate in mouse macrophages [Ref6563:Vincent et al., 2006]. 16997951 1444 feoB from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3079487 52842863 lpg2657 YP_096662.1 ferrous iron transporter B Virulence factor MUTATION: feoB mutant is attenuated in human macrophages [Ref6569:Robey and Cianciotto, 2002]. COG0370P, under P: Inorganic ion transport and metabolism 12228295 1445 ptsP from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3079830 52843066 lpg2871 YP_096865.1 phosphoenolpyruvate protein phosphotransferase PtsP Virulence factor MUTATION: ptsP mutant is attenuated in guinea pigs [Ref6570:Higa and Edelstein, 2001]. COG3605T, under T: Signal transduction mechanisms 11447151 1446 icmG from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3079958 52840697 lpg0452 YP_094496.1 IcmG (DotF) Virulence factor MUTATION: icmG mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. 10393970 1447 icmB from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3080126 52840701 lpg0456 YP_094500.1 IcmB (DotO) Virulence factor MUTATION: icmB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. 10393970 1448 rpoS from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3080381 52841515 lpg1284 YP_095314.1 stationary phase specific sigma factor RpoS Virulence factor MUTATION: rpoS mutant is defective in intracellular replication in its protozoan host [Ref6571:Hovel-Miner et al., 2009]. COG0568K, under K: Transcription 19218380 1449 djlA from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3080541 52842551 lpg2341 YP_096350.1 Dna-J like membrane chaperone protein Virulence factor MUTATION: djlA mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. 16997951 1450 lpg2515 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 3080592 52842723 lpg2515 AE017354 YP_096522 structural toxin protein (hemagglutinin/hemolysin) RtxA Virulence factor MUTATION: rtxA mutant is attenuated in mice and does not replicate as well as the wild type in monocytes [Ref6572:Cirillo et al., 2001]. COG3323S, under S: Function unknown 11119544 1452 plaB from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3113555 54294354 lpl1422 YP_126769.1 phospholipase Virulence factor MUTATION: plaB mutant is attenuated in guinea pigs [Ref6574:Schunder et al., 2010]. 20153694 1453 ptsP from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3113668 54295696 lpl2784 YP_128111.1 phosphoenolpyruvate-protein phosphotransferase PtsP Virulence factor MUTATION: ptsP mutant is attenuated in guinea pigs [Ref6570:Higa and Edelstein, 2001]. COG3605T, under T: Signal transduction mechanisms 11447151 1454 dotA from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3113684 54295526 lpl2613 YP_127941.1 defect in organelle trafficking protein DotA Virulence factor MUTATION: dotA mutant is unable to replicate in mouse macrophages [Ref6563:Vincent et al., 2006]. 16997951 1455 djlA from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3113813 54295182 lpl2262 YP_127597.1 Dna-J like membrane chaperone protein Virulence factor MUTATION: djlA mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. COG1076O, under O: Posttranslational modification, protein turnover, chaperones 16997951 1456 icmX from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3114023 54295529 lpl2616 YP_127944.1 Intracellular multiplication protein IcmX Virulence factor MUTATION: icmX mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. 10393970 1457 rtxA-2 Legionella pneumophila str. Lens 3114223 54293628 lpl0681 CR628337 YP_126043 structural toxin protein RtxA Virulence factor MUTATION: rtxA mutant is attenuated in mice and doesn't grow as well in monocytes as the wild type [Ref6572:Cirillo et al., 2001]. 11119544 1458 mip from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3114458 54293773 lpl0829 YP_126188.1 macrophage infectivity potentiator Virulence factor MUTATION: mip mutants are approximately 50- to 100-fold less infective for A. castellanii and for human mononuclear phagocytes in vitro compared with their isogenic Mip-positive parental strains [Ref6564:Wintermeyer et al., 1995]. COG0545O, under O: Posttranslational modification, protein turnover, chaperones 7591108 1459 flaA from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3114487 54294228 lpl1293 YP_126643.1 flagellin Virulence factor MUTATION: flaA mutant is less invasive of HL-60 cells than the wild type [Ref6575:Dietrich et al., 2001]. COG1344N, under N: Cell motility 11254565 1460 fur from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3114575 54293365 lpl0414 YP_125780.1 Ferric uptake regulation protein Virulence factor MUTATION: fur mutant has attenuated intracellular growth within U937 cell monolayers [Ref6569:Robey and Cianciotto, 2002]. COG0735P, under P: Inorganic ion transport and metabolism 12228295 1461 sdhA from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3114696 54293370 lpl0419 YP_125785.1 SdhA, substrate of the Dot/Icm system Virulence factor MUTATION: sdhA mutant is attenuated in mouse macrophages [Ref6576:Laguna et al., 2006]. 17124169 1462 dotB from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3114737 54295516 lpl2603 YP_127931.1 defect in organelle trafficking protein DotB (ATPase) Virulence factor MUTATION: dotB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. COG2805NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 10393970 1463 iraA from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3114746 54293731 lpl0784 YP_126146.1 small-molecule methyltransferase IraA Virulence factor MUTATION: iraA mutant is attenuated in guinea pigs [Ref6577:Viswanathan et al., 2000]. COG2226H, under H: Coenzyme transport and metabolism 10678909 1464 rpoS from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3114978 54294183 lpl1247 YP_126598.1 RNA polymerase sigma factor RpoS Virulence factor MUTATION: rpoS mutant is defective in intracellular replication in its protozoan host [Ref6571:Hovel-Miner et al., 2009]. COG0568K, under K: Transcription 19218380 1465 lvgA from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3115099 54293520 lpl0571 YP_125935.1 hypothetical protein Virulence factor MUTATION: lvgA mutant is attenuated in guinea pigs [Ref6578:Edelstein et al., 2003]. 12704109 1466 cpxR from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3115566 54294527 lpl1603 YP_126942.1 transcriptional regulatory protein CpxR Virulence factor MUTATION: cpxR mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 16997951 1467 feoB from Legionella pneumophila str. Lens Legionella pneumophila str. Lens 3115599 54295497 lpl2584 YP_127912.1 ferrous iron transporter B Virulence factor MUTATION: feoB mutant is attenuated in human macrophages [Ref6569:Robey and Cianciotto, 2002]. COG0370P, under P: Inorganic ion transport and metabolism 12228295 1468 plaB from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3116520 54297520 lpp1568 YP_123889.1 phospholipase Virulence factor MUTATION: plaB mutant is attenuated in guinea pigs [Ref6574:Schunder et al., 2010]. 20153694 1469 iraA from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3116645 54296774 lpp0813 YP_123143.1 small-molecule methyltransferase IraA Virulence factor MUTATION: iraA mutant is attenuated in guinea pigs [Ref6577:Viswanathan et al., 2000]. COG2226H, under H: Coenzyme transport and metabolism 10678909 1470 lvgA from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3116728 54296559 lpp0590 YP_122928.1 hypothetical protein Virulence factor MUTATION: lvgA mutant is attenuated in guinea pigs [Ref6578:Edelstein et al., 2003]. 12704109 1471 rpoS from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3117391 54297202 lpp1247 YP_123571.1 RNA polymerase sigma factor RpoS Virulence factor MUTATION: rpoS mutant has defective intracellular replication in its protozoan host [Ref6571:Hovel-Miner et al., 2009]. COG0568K, under K: Transcription 19218380 1472 rtxA-1 Legionella pneumophila str. Paris 3117483 54296668 lpp0699 CR628336 YP_123037 structural toxin protein RtxA Virulence factor MUTATION: rtxA mutant is attenuated in mice and doesn't grow as well in monocytes as the wild type [Ref6572:Cirillo et al., 2001]. COG2931Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 11119544 1473 sdhA from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3117748 54296413 lpp0443 YP_122782.1 SdhA, substrate of the Dot/Icm system Virulence factor MUTATION: sdhA mutant is attenuated in mouse macrophages [Ref6576:Laguna et al., 2006]. 17124169 1474 dotA from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3117985 54298676 lpp2740 YP_125045.1 defect in organelle trafficking protein DotA Virulence factor MUTATION: dotA mutant is unable to replicate in mouse macrophages [Ref6563:Vincent et al., 2006]. 16997951 1475 dotB from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3117986 54298666 lpp2730 YP_125035.1 defect in organelle trafficking protein DotB (ATPase) Virulence factor MUTATION: dotB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. COG2805NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 10393970 1476 icmX from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3118177 54298679 lpp2743 YP_125048.1 Intracellular multiplication protein IcmX Virulence factor MUTATION: icmX mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. 10393970 1477 cpxR from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3118718 54297348 lpp1393 YP_123717.1 transcriptional regulatory protein CpxR Virulence factor MUTATION: cpxR mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 16997951 1478 ptsP from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3118937 54298863 lpp2930 YP_125232.1 phosphoenolpyruvate-protein phosphotransferase PtsP Virulence factor MUTATION: ptsP mutant is attenuated in guinea pigs [Ref6570:Higa and Edelstein, 2001]. COG3605T, under T: Signal transduction mechanisms 11447151 1479 fur from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3119216 54296409 lpp0438 YP_122778.1 Ferric uptake regulation protein Virulence factor MUTATION: fur mutant is attenuated in growth within U937 cell monolayers[Ref6579:Hickey and Cianciotto, 1997]. COG0735P, under P: Inorganic ion transport and metabolism 8975903 1480 mip from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3119248 54296815 lpp0855 YP_123184.1 macrophage infectivity potentiator Virulence factor MUTATION: mip mutants are approximately 50- to 100-fold less infective for A. castellanii and for human mononuclear phagocytes in vitro compared with their isogenic Mip-positive parental strains [Ref6564:Wintermeyer et al., 1995]. COG0545O, under O: Posttranslational modification, protein turnover, chaperones 7591108 1481 feoB from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3119310 54298647 lpp2711 YP_125016.1 ferrous iron transporter B Virulence factor MUTATION: feoB mutant is attenuated in human macrophages [Ref6569:Robey and Cianciotto, 2002]. COG0370P, under P: Inorganic ion transport and metabolism 12228295 1482 flaA from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3119334 54297249 lpp1294 YP_123618.1 flagellin Virulence factor MUTATION: flaA mutant is less invasive of HL-60 cells than the wild type [Ref6575:Dietrich et al., 2001]. COG1344N, under N: Cell motility 11254565 1483 djlA from Legionella pneumophila str. Paris Legionella pneumophila str. Paris 3119498 54298231 lpp2289 YP_124600.1 Dna-J like membrane chaperone protein Virulence factor MUTATION: djlA mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. COG1076O, under O: Posttranslational modification, protein turnover, chaperones 16997951 1827 mip from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5180329 148360557 LPC_2500 YP_001251764.1 macrophage infectivity potentiator (Mip) Virulence factor MUTATION: mip mutants are approximately 50- to 100-fold less infective for A. castellanii and for human mononuclear phagocytes in vitro compared with their isogenic Mip-positive parental strains [Ref6564:Wintermeyer et al., 1995]. COG0545O, under O: Posttranslational modification, protein turnover, chaperones 7591108 1828 iraA from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5180371 148360599 LPC_2545 YP_001251806.1 small-molecule methyltransferase IraA Virulence factor MUTATION: iraA mutant is attenuated in guinea pigs [Ref6577:Viswanathan et al., 2000]. COG2226H, under H: Coenzyme transport and metabolism 10678909 1829 rpoS from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5180541 148358826 LPC_0709 YP_001250033.1 stationary phase specific sigma factor RpoS Virulence factor MUTATION: rpoS mutant has defective intracellular replication in its protozoan host [Ref6571:Hovel-Miner et al., 2009]. COG0568K, under K: Transcription 19218380 1830 cpxR from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5180685 148358969 LPC_0854 YP_001250176.1 transcriptional regulatory protein CpxR Virulence factor MUTATION: cpxR mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 16997951 1831 plaB from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5180855 148359137 LPC_1029 YP_001250344.1 phospholipase Virulence factor MUTATION: plaB mutant is attenuated in guinea pigs [Ref6574:Schunder et al., 2010]. 20153694 1832 djlA from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5181617 148359881 LPC_1809 YP_001251088.1 Dna-J like membrane chaperone protein Virulence factor MUTATION: djlA mutant is attenuated in mouse macrophages [Ref6563:Vincent et al., 2006]. COG1076O, under O: Posttranslational modification, protein turnover, chaperones 16997951 1833 icmX from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5182246 148358575 LPC_0447 YP_001249782.1 Intracellular multiplication protein IcmX Virulence factor MUTATION: icmX mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. 10393970 1834 dotA from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5182249 148358578 LPC_0450 YP_001249785.1 defect in organelle trafficking protein DotA Virulence factor MUTATION: dotA mutant is unable to replicate in mouse macrophages [Ref6563:Vincent et al., 2006]. 16997951 1835 dotB from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5182260 148358589 LPC_0461 YP_001249796.1 defect in organelle trafficking protein DotB (ATPase) Virulence factor MUTATION: dotB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. COG2805NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 10393970 1836 feoB from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5182279 148358608 LPC_0482 YP_001249815.1 ferrous iron transporter B Virulence factor MUTATION: feoB mutant is attenuated in human macrophages [Ref6569:Robey and Cianciotto, 2002]. COG0370P, under P: Inorganic ion transport and metabolism 12228295 1837 lvgA from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5182556 148360819 LPC_2777 YP_001252026.1 hypothetical virulence protein Virulence factor MUTATION: lvgA mutant is attenuated in guinea pigs [Ref6578:Edelstein et al., 2003]. 12704109 1838 icmB from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5182665 148360927 LPC_2887 YP_001252134.1 IcmB (DotO) Virulence factor MUTATION: icmB mutant is attenuated in guinea pigs [Ref6567:Edelstein et al., 1999]. 10393970 1839 icmG from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5182669 148360931 LPC_2891 YP_001252138.1 IcmG (DotF) Virulence factor MUTATION: icmG mutant is attenuated in mice [Ref6567:Edelstein et al., 1999]. 10393970 1840 fur from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5182750 148361012 LPC_2972 YP_001252219.1 Ferric uptake regulation protein Virulence factor MUTATION: fur mutant is attenuated in growth within U937 cell monolayers [Ref6579:Hickey and Cianciotto, 1997]. COG0735P, under P: Inorganic ion transport and metabolism 8975903 1841 ptsP from Legionella pneumophila str. Corby Legionella pneumophila str. Corby 5182932 148361183 LPC_3157 YP_001252390.1 phosphoenolpyruvate protein phosphotransferase PtsP Virulence factor MUTATION: ptsP mutant is attenuated in guinea pigs [Ref6570:Higa and Edelstein, 2001]. COG3605T, under T: Signal transduction mechanisms 11447151 4188 lpa_03874 Legionella pneumophila 2300/99 Alcoy 9130593 296108291 lpa_03874 CP001828 YP_003619992 Legionella transmission activator LetA Virulence factor MUTATION: letA mutant is non-motile and is attenuated for infecting murine macrophages [Ref6902:Hammer et al., 2002]. COG2197TK, under T: Signal transduction mechanisms; K: Transcription 11967072 4458 katB Legionella pneumophila 3764089 Virulence factor MUTATION: katB mutant is delayed in the infection and lysis of cultured macrophage-like cell lines ; [Ref6996:Bandyopadhyay and Steinman, 1998]. 9765568 4459 lbtA Legionella pneumophila 130b 71726458 71726459 AAZ39407.1 legiobactin biosynthesis protein A Virulence factor MUTATION: lbtA mutant displayed a reduced ability to infect the lungs of A/J mice after intratracheal inoculation; [Ref6997:Allard et al., 2009]. 19398549 4460 milA Legionella pneumophila AA100 5702298 5702299 AAD47247.1 putative transport protein Virulence factor MUTATION: milA mutant is defective in intracellular replication in macrophages [Ref6998:Harb and Abu, 2000]. 10603410 4867 LPS Legionella pneumophila Virulence factor MUTATION: mutant 811 (an LPS mutant) has reduced ability to replicate in guinea pigs and is not serum resistant [Ref7292:Lüneberg et al., 1998]. 9653083 5194 tolC Legionella pneumophila str. Lens 3114064 54293683 lpl0736 CR628337 YP_126098 hypothetical protein Virulence factor Deletion of tolC by allelic exchange in L. pneumophila caused increased sensitivity to various drugs. The complementation of the tolC mutation in trans restored drug resistance, indicating that TolC is involved in multi-drug efflux machinery. In addition, deletion of tolC caused a significant attenuation of virulence towards both amoebae and macrophages.[Ref7592:Ferhat et al., 2009]; 19888467 5216 iraA Legionella pneumophila str. Paris 3116645 54296774 lpp0813 CR628336 YP_123143 small-molecule methyltransferase IraA Virulence factor NU216R-infected animals yielded 1,000-fold fewer bacteria from their lungs and spleen compared to wild-type-130b-infected animals that had received a 50-fold-lower dose. Moreover, NU216R-infected animals subsequently cleared the bacteria from these sites.[Ref6577:Viswanathan et al., 2000]; 10678909