Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

pyrB from Brucella suis 1330

Victor ID 997
Gene Name pyrB from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165039
NCBI Protein GI 23500343
Locus Tag BRA0599
Protein Accession NP_699783.1
Other Database IDs UniProtKB-ID: PYRB_BRUSU
UniRef100: UniRef100_B2SB57
UniRef90: UniRef90_B2SB57
UniRef50: UniRef50_A4VRI1
UniParc: UPI000005858D
EMBL: AE014292
EMBL-CDS: AAN33788.1
RefSeq_NT: NC_004311.2
GenomeReviews: AE014292_GR
KEGG: bms:BRA0599
TIGR: BRA0599
HOGENOM: HBG579429
OMA: MNRGLEI
ProtClustDB: PRK00856
BioCyc: BSUI204722:BR_A0599-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 584754
Gene Ending Position 585722
Gene Strand (Orientation) +
Protein Name aspartate carbamoyltransferase catalytic subunit
DNA Sequence 
>gi|56968493:584754-585722 Brucella suis 1330 chromosome II, complete genome
CATGACAAATCAAACGGTCTCTCCGCTTTTCCCTCACCGCCACCTGCTTGGCATCAAGGGGCTATCGCCC
CTGGACATTCTCTGCCTTCTCGATCTTGCCGATCAGGAAATCGCTGTCTCCCGGCAGCCGGAGAAGAAAA
AGTCCGTGCTGCGCGGTCGCACGCAAATCAACCTGTTCTTTGAAGCATCGACACGGACGCAATCTTCGTT
CGAGCTGGCCGGAAAACGGCTGGGCGCGGATGTGATGAATATGTCCGTCGGCAATTCATCGGTCAAGAAA
GGCGAAACGCTCATCGATACGGCGATGACGCTGAACGCCATGCAGCCGGATATTCTCGTCATCCGCCATG
CTTCCGCCGGTGCTGCCGCCCTTCTCGCGCAGAAAGTGGGTTGCTCGGTGGTCAATGCGGGCGACGGCGC
GCATGAACACCCCACACAGGCGCTTCTCGATGCGCTGACAATCCGCCGCGCCAAGGGCCAGATCGAAAAT
CTGATCGTCGCCATCTGCGGTGACGTTCTGCATTCGCGCGTGGCGCGCTCCAACATTCTCCTGCTCAACG
CGCTCGGCGCGCGGGTGCGGGTGGTTGCGCCTTCAACACTCCTGCCCGCCGGCATGGCCGATATGAGCGT
GGAAGTTTTCAACTCCATGGAGGAGGGGCTGAAAGACGCTGATGTCGTCATGATGCTGCGCCTCCAGCGC
GAGCGCATGGCGGGTTCCTTCGTGCCTTCCGTGCGGGAATATTTCCATTTCTATGGCCTGGACCGGGAAA
AACTCAAATTCGCCAAACCTGATGCACTTGTGATGCATCCGGGGCCGATGAACCGGGGCGTCGAGATTGC
CTCCGACGTTGCGGACGGGCCGCAAAGCGTCATCCAGCAACAGGTGGAAATGGGCGTTGCCGTGCGCATG
GCCGTGATGGAGGCTCTGCTCGATCCGCGGCGCAACCCAGGCAACGGAGAACCGGCATG
Protein Sequence 
>gi|23500343|ref|NP_699783.1| aspartate carbamoyltransferase [Brucella suis 1330] MTNQTVSPLFPHRHLLGIKGLSPLDILCLLDLADQEIAVSRQPEKKKSVLRGRTQINLFFEASTRTQSSFELAGKRLGADVMNMSVGNSSVKKGETLIDTAMTLNAMQPDILVIRHASAGAAALLAQKVGCSVVNAGDGAHEHPTQALLDALTIRRAKGQIENLIVAICGDVLHSRVARSNILLLNALGARVRVVAPSTLLPAGMADMSVEVFNSMEEGLKDADVVMMLRLQRERMAGSFVPSVREYFHFYGLDREKLKFAKPDALVMHPGPMNRGVEIASDVADGPQSVIQQQVEMGVAVRMAVMEALLDPRRNPGNGEPA
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate(UniProt: P65612).

PATHWAY: Nucleotide biosynthesis; UMP biosynthesis; UMP from HCO(3)(-): step 2(UniProt: P65612).

PATHWAY: Context: Pyrimidine biosynthesis(UniProt: P65612).

SIMILARITY: Belongs to the ATCase/OTCase family(UniProt: P65612).

MUTATION: B. abortus pyrB (pyrimidines) gene is essential for intracellular growth in HeLa cells as shown from transposon mutagenesis study (Kim et al., 2003).
COG COG0540F, under F: Nucleotide transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].