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cydB from Brucella suis 1330

Victor ID 993
Gene Name cydB from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1164949
NCBI Protein GI 23500258
Locus Tag BRA0511
Protein Accession NP_699698.1
Other Database IDs UniProtKB-ID: Q8FWE4_BRUSU
UniRef100: UniRef100_D0B6V5
UniRef90: UniRef90_D0B6V5
UniRef50: UniRef50_P26458
UniParc: UPI00000DD984
EMBL: AE014292
EMBL-CDS: AAN33703.1
RefSeq_NT: NC_004311.2
GenomeReviews: AE014292_GR
KEGG: bms:BRA0511
NMPDR: fig|204722.1.peg.2607
TIGR: BRA0511
HOGENOM: HBG413915
OMA: DLTIYNA
ProtClustDB: CLSK898928
BioCyc: BSUI204722:BR_A0511-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 491456
Gene Ending Position 492610
Gene Strand (Orientation) +
Protein Name cytochrome d ubiquinol oxidase, subunit II
DNA Sequence 
>gi|56968493:491456-492610 Brucella suis 1330 chromosome II, complete genome
CATGATACTCAGCGATTTGTTGGACTATCAAACCCTGCGGATCATCTGGTGGGTGCTGCTCGGCGTGCTG
CTGATCGGCTTTGCCGCCATGGATGGTTTCGACCTCGGCGTCGGCACGCTTCTGCCTTTCGTTGCCAGAA
CCGATGTGGAGCGTCGCGTCGTCATCAATACAATCGGCCCCGTCTGGGAAGGCAATCAGGTCTGGTTGAT
CCTTGGCGGCGGTGCGATCTTCGCCGCCTGGCCGCCGCTTTATGCGGTGTCCTTCTCCGGGTTCTATCTG
GCGATGTTCGTCATCCTGTTCGCGCTCATCCTGCGCCCGGTCGGCTTCAAGTTCCGCTCCAAGCGTGATG
GAGAAACCTGGCGCAACAGTTGGGACTGGGCGCTGTTCATCGGCGGCTTCGTGCCGGCGCTGATCTTCGG
CGTGGCGGTTGGAAATGTGCTTCAGGGGGTTCCCTTCCGGCTCAACGGCGATCTCCAGATCTTCTACGAA
GGCTCATTCTTCGGCCTGCTCAATCCGTTTGCGCTTCTGTGCGGCATCCTGTCCGTCACCATGCTCACCA
TGCATGGCGCGGCATGGCTCGTTTTGAAGACAGATGGCGTGATACAGGCGCGGGCGCGGGCCTATGGCAG
CGTTGCGGCGCTGTTGACCGTCATTCTCTACATCGTCGCCGGTGCCATAAGCTGGCTTTGGGTGTCGGGG
TATCGCATAACCAGTGCGGTGGTGATGGACGGGCCTTCCAACCCGCTGCAAAAGACCGTGGAACTGGATC
ACGGCGCCTGGTTTGCGAACTATGCGAATTATCCGATCCTGCTGATCGCGCCTGCGCTTGGCATTCTCGG
TGCGCTCGCGGTTCTCGCAACGCTACGCGGCGGTCGTGAACTTGCTCCGCTCCTCTTCGGAAAACTCTCG
ATCTTCGGCATCATCTCGTCTGTCGGCGTGTCGATGTTTCCGTTCATCCTGCCGTCTTCCATCGATCCGC
AATCGAGCCTGACGGTCTGGGATTCATCGTCCAGCCATCAGACGCTGTTCATCATGCTGGTGGTAACGGT
CGTCTTCATTCCGATCATCGTCGCCTATACCGCATGGGTCTATAAGGTCCTTTGGGGCAAGGTGGACAAG
AGCATGATCGAGGATGAGAGCAACCACGCTTACTG
Protein Sequence 
>gi|23500258|ref|NP_699698.1| cytochrome d ubiquinol oxidase subunit II [Brucella suis 1330] MILSDLLDYQTLRIIWWVLLGVLLIGFAAMDGFDLGVGTLLPFVARTDVERRVVINTIGPVWEGNQVWLILGGGAIFAAWPPLYAVSFSGFYLAMFVILFALILRPVGFKFRSKRDGETWRNSWDWALFIGGFVPALIFGVAVGNVLQGVPFRLNGDLQIFYEGSFFGLLNPFALLCGILSVTMLTMHGAAWLVLKTDGVIQARARAYGSVAALLTVILYIVAGAISWLWVSGYRITSAVVMDGPSNPLQKTVELDHGAWFANYANYPILLIAPALGILGALAVLATLRGGRELAPLLFGKLSIFGIISSVGVSMFPFILPSSIDPQSSLTVWDSSSSHQTLFIMLVVTVVFIPIIVAYTAWVYKVLWGKVDKSMIEDESNHAY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cydB is a gene that is part of the cydAB operon encoding cytochrome bd oxidase , which catalyzes an alternate terminal electron transport step in bacterial respiration. Transposon (Tn5) mutagenesis of B abortus cydB was severely attenuated for intracellular survival. Unlike the virulent strain 2308, the Brucella cydB::Tn5 mutant was severely compromised for survival in the spleens of inoculated mice (Endley et al., 2001). The cydB and cydD mutants are also defective for the intracellular growth of B abortus and B suis, suggesting that functional cytochrome bd oxidase is required for growth in an intracellular environment (Endley et al., 2001).
COG COG1294C, under C: Energy production and conversion
References
Endley et al., 2001: Endley S, McMurray D, Ficht TA. Interruption of the cydB locus in Brucella abortus attenuates intracellular survival and virulence in the mouse model of infection. Journal of bacteriology. 2001; 183(8); 2454-2462. [PubMed: 11274104].