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glpK from Brucella suis 1330

Victor ID 989
Gene Name glpK from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1164881
NCBI Protein GI 23500192
Locus Tag BRA0443
Protein Accession NP_699632.1
Other Database IDs UniProtKB-ID: GLPK_BRUSU
UniRef100: UniRef100_Q8FWK8
UniRef90: UniRef90_A9MB89
UniRef50: UniRef50_A4J8E6
UniParc: UPI00000DD950
EMBL: AE014292
EMBL-CDS: AAN33637.1
RefSeq_NT: NC_004311.2
GenomeReviews: AE014292_GR
KEGG: bms:BRA0443
NMPDR: fig|204722.1.peg.2541
TIGR: BRA0443
HOGENOM: HBG511469
OMA: GWVEHEP
ProtClustDB: CLSK863056
BioCyc: BSUI204722:BR_A0443-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 430457
Gene Ending Position 431953
Gene Strand (Orientation) -
Protein Name glycerol kinase
DNA Sequence 
>gi|56968493:430457-431953 Brucella suis 1330 chromosome II, complete genome
TCTATTGCGGTCGTGTGAGGCAGCGTGAAACGCTATCCCGCCAGCCCGCAATCGCGCTTTCACGTTCTTT
TTCCGGCATAGCCGGCTCAAACCTGCAATCACGCTGCCAGCGTTCCGAAAAACCCTTGCGATCCGGCCAG
ATGCCTGCGCGGGAGGCGGCCAGCCATGCGGCGCCCAGCACGGTGGTTTCGAGAAAAACCGGGCGATCGA
CGGGTGCGTTCAGAATGTCGGCCAGTCGCTGCATGGTCCAGTCGGAAGCAACCATGCCTCCATCGACGCG
CAGCACCGTGTGATTGGTTGCGCCTTTCCAGTCCCCTTGCATGGCTTCCAGAAGGTCGAAGGTCTGATAG
GCCACGCTTTCAAGTGCTGCGCGGGCAAATTCTGCGCGGCCCGTCCCGCGCGTCAACCCGAAGATTGCGC
CGCGCGCTTCGGCGTCCCAATAGGGTGCGCCAAGCCCGGTGAAGGCTGGAACCAGATAGATGCGCTGGTT
CGGGTCGGCCTTTTCGGCCAGCGCGCTTACTTCCGATACGACCGAAATGAAGCCCATTTCGTCACGAAGC
CATTGTACGGCCGCGCCCGCGATGAATATCGAACCTTCCAGCGCATAGGTCGTAACACCGTCGAGCCGGT
AGGCGATGGTGGTGAGCAGCCGGTTGGAGGAGGTGACGCGATCCGTGCCGGTGTTGAGAAGTGCAAAACA
TCCGGTGCCGTAGGTGGATTTCATCATGCCTGGCTCGAAGCAGGCATTGCCGATCACTGCCGTCTGCTGG
TCGCCCGCTACGCCGAGAATAGGAATGGAAACGCCGAAAAGGGCAGGGTCCGTCATGCCGAAATCCGCCG
CGCAGTCCTTCACTTCCGGCAGCATGGCGGCTGGAATGCCCAATATGTCCAGCAGTTCATCATCCCAACG
GTTTTCGCCGATATGATAGATCAATGTACGCGAGGCATTCGTGGCGTCGGTTACATGCGCCTTGCCGCCG
GTGAGCTTGTAGATCAGCCAGCTATCGATGGTGCCGAAGCAGACTTGACCTTTTTGCGCACGCTCGCGCA
GGCCCGGAACATGGTTCAGCAACCATGCAAGTTTCGTCCCGGAAAAATAGGGGTCGAGCAGCAGCCCGGT
CTTTTCCGTAAAGAGAGGTTCAAGATTGCGGCGCTTCAGTTCGTCGCAAAACTGCGCCGTGCGGCGATCC
TGCCAGACAATGGCGCGGTGTACCGGCTTGCCGCTTATGCGGTCCCATACGACGGTTGTTTCGCGCTGAT
TGGTGATGCCGATCGCCGCGACGTCTGCCGCACTGATGCCAGCTTGTGCAAGTGCTATGCGGATAGTGGA
CTGCACCGATTTCCAGATTTCTTCCGCATCGTGCTCCACCCAGCCGGAGGAAGGAAAATGCTGCGTAAAT
TCCTGCTGCCCCAACCCCACGACCCGCATATTCCTGTCGAACAGCATCGACCTTGTGGAGGTGGTTCCCT
GATCGATAGCCAGAATATATCCGCTCA
Protein Sequence 
>gi|23500192|ref|NP_699632.1| glycerol kinase [Brucella suis 1330] MSGYILAIDQGTTSTRSMLFDRNMRVVGLGQQEFTQHFPSSGWVEHDAEEIWKSVQSTIRIALAQAGISAADVAAIGITNQRETTVVWDRISGKPVHRAIVWQDRRTAQFCDELKRRNLEPLFTEKTGLLLDPYFSGTKLAWLLNHVPGLRERAQKGQVCFGTIDSWLIYKLTGGKAHVTDATNASRTLIYHIGENRWDDELLDILGIPAAMLPEVKDCAADFGMTDPALFGVSIPILGVAGDQQTAVIGNACFEPGMMKSTYGTGCFALLNTGTDRVTSSNRLLTTIAYRLDGVTTYALEGSIFIAGAAVQWLRDEMGFISVVSEVSALAEKADPNQRIYLVPAFTGLGAPYWDAEARGAIFGLTRGTGRAEFARAALESVAYQTFDLLEAMQGDWKGATNHTVLRVDGGMVASDWTMQRLADILNAPVDRPVFLETTVLGAAWLAASRAGIWPDRKGFSERWQRDCRFEPAMPEKERESAIAGWRDSVSRCLTRPQ
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Key enzyme in the regulation of glycerol uptake and metabolism(UniProt: Q8FWK8).

CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-phosphate(UniProt: Q8FWK8).

PATHWAY: Glycerol utilization; first (rate-limiting) step(UniProt: Q8FWK8).

SIMILARITY: Belongs to the FGGY kinase family(UniProt: Q8FWK8).

MUTATION: Attenuated in Mice, Macrophages, HeLa (Delrue et al., 2004).
COG COG0554C, under C: Energy production and conversion
References
Delrue et al., 2004: Delrue RM, Lestrate P, Tibor A, Letesson JJ, De Bolle X. Brucella pathogenesis, genes identified from random large-scale screens. FEMS microbiology letters. 2004; 231(1); 1-12. [PubMed: 14979322].