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norD

Victor ID 982
Gene Name norD
Sequence Strain (Species/Organism) Brucella
NCBI Gene ID 1164688
NCBI Protein GI 23500008
Locus Tag BRA0251
Protein Accession NP_699448.1
Other Database IDs UniProtKB-ID: NORD_BRUSU
UniRef100: UniRef100_Q8FX38
UniRef90: UniRef90_Q2YJT9
UniRef50: UniRef50_Q2YJT9
UniParc: UPI00000DD8AF
EMBL: AE014292
EMBL-CDS: AAN33453.1
RefSeq_NT: NC_004311.2
GenomeReviews: AE014292_GR
KEGG: bms:BRA0251
NMPDR: fig|204722.1.peg.2357
TIGR: BRA0251
HOGENOM: HBG360249
OMA: GYYTRMG
ProtClustDB: CLSK881706
BioCyc: BSUI204722:BR_A0251-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 233792
Gene Ending Position 235693
Gene Strand (Orientation) +
Protein Name norD protein
DNA Sequence 
>gi|56968493:233792-235693 Brucella suis 1330 chromosome II, complete genome
CATGCTGGATTTTCTGGAGCTTGAGGAAACCGTCGGCCGGGCCTGGCATCGCCTTATCGGCAAGACCGGC
TCATGGCCGCAATATCCCGATCATGCCGTGCAGCTTGTCGATATACGCCAGCGGCTTGCCATCTGCTTTC
GCGGTTTCGGCGGCGATATAGCGGTGCAAATTGCGCCAGCGCGCGCACGCACCTCGACCCACCGCCTTGG
CCTGCGCCGGCGGATGGCGCTTGGCGAGGAAAAGCTCGCCCAGCCGCTGCGCGATGAGGCGACCTTGATG
CTGCCGCCGGAAATTGCACTCTTTCCGGATCGCCAGCTCAATTACGATCTCTACGTCTGGCTGGTCGGCT
ATATGGCCGTCATGCCCATGGATGCCGACGCACTGCCGGAAGATGCGCTGCGGCGCGACCTTGCCGCACT
CCAGATCGCCGAGCAGACGGTGGAACGGGCCTGCCGCGCCTTTCCCGGATTGAAACCGCGCTACAAGCGG
CTTTGCGCGGCTATACTGGCAGAGCGCCCGAAGCGCCCGCTGCACCGGCTCGAACAGCAGGTGGAAGCGC
GCATTCTGTCGCTTCTCAAACAGGGTGCGGACCTGCCCGATGACGCCTTGCCCACCATTTTTCCGCATCG
CGGGCCTGCGGGCTATCTGCCGGCCCTGCCGGTGCCGCTATGGCCGGGCCTGATGAAGCGTGAGGAAGTC
GCGCCACGCACTGGCGAGGACGAGCCGGTGCGCAACAGCCAGTCTGAGGGCGCCGAAACCGGACGCCAGA
TCGCCCAGCGTGAGCGGCAGGACCCGCGCCATGCCGACCGCAGCCCGTTCATCCTCAACCGCTTCGAGAA
AATTCTCGCCATGGCGGAAATGGTGAGCGTGGACCGCCCTTCCGATGACAGCGACGAACAGAATGCGAAA
TCGGCGGATGAACTTGACGACCTGACGCTCGGTGAACGCAAAGGCCGGCCAGCGGCACGCTTCCGCTTCG
ATCTTGATCTGCCGCCGGAAGCGGTGGATCGCAGCCTGCTCACCGCCGAACTGACCTATCCCGAATGGGA
TTACCGCAAGGGGGCGTATCTGCCCGACCATTGCGCGGTTCTGGCCGCGCCAGTACAGGAAAAGGAAAAG
CCTCTGGAACTGGATGCCGCGGCACAAAGCCTCGTGCGACGTGTGCGCCGCCAGTTTGAAATCCTGCGTC
CCGGCCGCGAAGTGTTGCGCGCGCAGCTTGACGGTACGGATCTCGACCTTGATGCCGTGGTGCGCTCGCG
CTGCGATCTGGCGGCGGGCGGGCAGGGCAGCGACCGCGTGCATCTGATGAGCCGCCCGCAGGCGAATGAT
CTTGCCGTCACTCTTCTGGTCGATGTTTCGCTCTCCACCGATGCCTGGGTCGACAACCGGCGGGTGCTCG
ATGTGGAAAAGGAGGCGCTTCTGGTTCTGGCAAATGGCATTGCCGCCTGCGGTGATCGCTGCTCCATCCT
CACCTTCACTTCCCGCCGCCGTTCATGGGTGCGGGTGGAGACGGTGAAGGATTTCGATGAAAGCTTCGGC
CCGACGGTGGAACATCGCATCGCCGCATTGAAGCCGGGCTTCTATACCCGTATGGGCGCTGCCATGCGGC
ACGCAACGGCAAAGCTTGCCGAACAGCCGAACCGCAAGAAGCTTCTTCTGCTCCTCACCGATGGCAAGCC
CAATGATGTGGACCATTACGAAGGCCGCTTTGCACTGGAAGACAGCCGCCGTGCGGCGGGCGAGGCCCGC
GCCAAAGGGGTCAATGTCTTTGCCGTAACGGTTGACCGTGAGGCAAGCGCCCATCTGCCCGCGCTTTTCG
GGCGTGGCGGTTATGCGCTCGTCGCCAATCTGGCGAAATTGCCGGTCGCACTGCCTGCGATCTATCGCAT
GTTGGCAGGCTG
Protein Sequence 
>gi|23500008|ref|NP_699448.1| norD protein [Brucella suis 1330] MLDFLELEETVGRAWHRLIGKTGSWPQYPDHAVQLVDIRQRLAICFRGFGGDIAVQIAPARARTSTHRLGLRRRMALGEEKLAQPLRDEATLMLPPEIALFPDRQLNYDLYVWLVGYMAVMPMDADALPEDALRRDLAALQIAEQTVERACRAFPGLKPRYKRLCAAILAERPKRPLHRLEQQVEARILSLLKQGADLPDDALPTIFPHRGPAGYLPALPVPLWPGLMKREEVAPRTGEDEPVRNSQSEGAETGRQIAQRERQDPRHADRSPFILNRFEKILAMAEMVSVDRPSDDSDEQNAKSADELDDLTLGERKGRPAARFRFDLDLPPEAVDRSLLTAELTYPEWDYRKGAYLPDHCAVLAAPVQEKEKPLELDAAAQSLVRRVRRQFEILRPGREVLRAQLDGTDLDLDAVVRSRCDLAAGGQGSDRVHLMSRPQANDLAVTLLVDVSLSTDAWVDNRRVLDVEKEALLVLANGIAACGDRCSILTFTSRRRSWVRVETVKDFDESFGPTVEHRIAALKPGFYTRMGAAMRHATAKLAEQPNRKKLLLLLTDGKPNDVDHYEGRFALEDSRRAAGEARAKGVNVFAVTVDREASAHLPALFGRGGYALVANLAKLPVALPAIYRMLAG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A mutant of Brucella suis bearing a Tn5 insertion in norD , the last gene of the operon norEFCBQD, encoding nitric oxide reductase, was unable to survive under anaerobic denitrifying conditions (more-than-5log reduction in viable counts). As a consequence of the norD mutation , NO might not be further reduced to N2O by the NO reductase and it could become toxic for the bacteria. The infection of resting macrophages showed that the norD mutant and the wild-type strain displayed similar rates of multiplication. On the contrary, activation of J774A.1 cells by LPS and IFN was accompanied by a more-thantenfold attenuation of the norD mutant at 48 h p. i. (Loisel-Meyer et al., 2006).
COG COG4548P, under P: Inorganic ion transport and metabolism
References
Loisel-Meyer et al., 2006: Loisel-Meyer S, Jiménez de Bagüés MP, Bassères E, Dornand J, Köhler S, Liautard JP, Jubier-Maurin V. Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection. Infection and immunity. 2006; 74(3); 1973-1976. [PubMed: 16495577].