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gnd from Brucella suis 1330

Victor ID 973
Gene Name gnd from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1164548
NCBI Protein GI 23499876
Locus Tag BRA0111
Protein Accession NP_699316.1
Other Database IDs UniProtKB-ID: Q8FXG6_BRUSU
UniRef100: UniRef100_A5VTM2
UniRef90: UniRef90_A6X6S9
UniRef50: UniRef50_A6UA87
UniParc: UPI00000DD842
EMBL: AE014292
EMBL-CDS: AAN33321.1
RefSeq_NT: NC_004311.2
HSSP: P00349
GenomeReviews: AE014292_GR
KEGG: bms:BRA0111
TIGR: BRA0111
HOGENOM: HBG286913
OMA: LQGQRDF
ProtClustDB: PRK09287
BioCyc: BSUI204722:BR_A0111-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 108327
Gene Ending Position 109736
Gene Strand (Orientation) +
Protein Name 6-phosphogluconate dehydrogenase
DNA Sequence 
>gi|56968493:108327-109736 Brucella suis 1330 chromosome II, complete genome
AATGGAAAAAGCAGATATCGGAATGGTCGGCCTTGGCGTCATGGGCTCCAACCTGGCGCTGAACATAGCC
GAGAAGGGCTACACCGTGGCCGTCTATGACCGTGATGAGCCTGTGCTGAAAGCTTTCATCGAAAAGGCTG
GCCGGCTGCGCGACAAGATCATTCCCTGCCCGACCTTTGAGGAACTGGCCGCGAATATCCGCAAGCCCCG
TCCGATCATCTTTCTCATCAAGGCCGGTGCGCCAGTCGATACCGAGACCACCCGCCTCAAGGCATTCCTT
GAGAAGGGCGATATCATGATCGATGCAGGCAATTCCGATTATCGCGATACGGTGCGCCGCCTGAAGGCTC
TTGGCCCCAATGATCCGACCTTTGTCGGCATGGGCGTTTCGGGTGGGGCGGAAGGCGCGCGCCATGGTCC
GTCGATGATGGTCGGCGGCACGGAGCAGGCCTATGAGCGCATCGCGCCGATCCTGCTTGCTGTCGCCGCC
AAATATCAGGGCGAGCCCTGCTGTGCGCTGGTCGGCCCGGATGGCGCGGGTCATTTCGTCAAAACCATCC
ATAACGGTATTGAATATGCCGATATGCAGATGATCGCCGAAATTTACGGCATTCTGCGCGATGGCCTTGG
CCTTTCAGCTCCGGCCATCGGCGATGTGTTCGAGAAGTGGAACGAAGGTCCGCTCAATTCCTATCTGATT
GAAATCACCGCCAAGGTTCTCAAGTCCACCGACCCGGAAACCGGCAAGGCGATGGTCGATATGATCCTTG
ATGAAGCCGGCCAGAAGGGTACAGGCCGCTGGGCTGCCATTGAGGCGCAGATACTGGGCGTTCCGGCCAC
GGGCATCGAAGCCGCGGTTGCCGCCCGTTCGCTGTCCTCCATGAAGGGCGAGCGGGAAGAGGCCGCCAAG
GCGTATAAATCCGGTGCACGCACACTTGATATTGCCAACCAGACCCGCTTCCTTTCCGATCTGGAACAGG
GCTTGCTGGCGGGCAAGATCGCCGCTTATGCGCAAGGCTTTGCAGTGATGGAAGCCGCCTCAAGGGAGCA
TGGCTGGAACATTCCGCTTGCCACCACGGCGCGCATCTGGCGCGCGGGCTGCATCATCCGCTCGCAGCTT
CTGGATGATATTGCGCAGGCTTTTGAAGGCAATGAAAGCCGTAACCTGCTCATGGCCCCGGCCTTCGTGC
CGCGCATGGAAACATCTGTGAAAAGCCTTCGCCAGATTGTCGCGCAGGCCGCCCTTGCCAGCCTGCCGCT
GCCCGCGCTCGGCTCTGCGCTCAGCTATTTCGACAGCTATACGCAGGCGCTTGGTACGGCCAATCTCATT
CAGGGCCAGCGCGATTTCTTCGGCTCGCACGGCTTCAAGCGCATTGACAAGGAGGGGGATTTCCACGGCC
CCTGGGGCTG
Protein Sequence 
>gi|23499876|ref|NP_699316.1| 6-phosphogluconate dehydrogenase [Brucella suis 1330] MEKADIGMVGLGVMGSNLALNIAEKGYTVAVYDRDEPVLKAFIEKAGRLRDKIIPCPTFEELAANIRKPRPIIFLIKAGAPVDTETTRLKAFLEKGDIMIDAGNSDYRDTVRRLKALGPNDPTFVGMGVSGGAEGARHGPSMMVGGTEQAYERIAPILLAVAAKYQGEPCCALVGPDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGLSAPAIGDVFEKWNEGPLNSYLIEITAKVLKSTDPETGKAMVDMILDEAGQKGTGRWAAIEAQILGVPATGIEAAVAARSLSSMKGEREEAAKAYKSGARTLDIANQTRFLSDLEQGLLAGKIAAYAQGFAVMEAASREHGWNIPLATTARIWRAGCIIRSQLLDDIAQAFEGNESRNLLMAPAFVPRMETSVKSLRQIVAQAALASLPLPALGSALSYFDSYTQALGTANLIQGQRDFFGSHGFKRIDKEGDFHGPWG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gnd is involved in pentose phosphate pathway. It is essential for intracellular growth inside HeLa cells as shown by its Brucella suis miniTn5Km2 transposon mutation analysis. The mutant is attenuated in the mouse model (Kim et al., 2003).
COG COG0362G, under G: Carbohydrate transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].