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virB2 from Brucella suis 1330

Victor ID 969
Gene Name virB2 from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1164505
NCBI Protein GI 23499835
Locus Tag BRA0068
Protein Accession NP_699275.1
Other Database IDs UniProtKB-ID: VIRB2_BRUSU
UniRef100: UniRef100_Q2YIT6
UniRef90: UniRef90_Q2YIT6
UniRef50: UniRef50_Q2YIT6
UniParc: UPI0000058309
EMBL: AF141604
EMBL: AE014292
EMBL-CDS: AAD56612.1
EMBL-CDS: AAN33280.1
RefSeq_NT: NC_004311.2
GenomeReviews: AE014292_GR
KEGG: bms:BRA0068
TIGR: BRA0068
HOGENOM: HBG683898
OMA: MAFAHAR
ProtClustDB: CLSK898648
BioCyc: BSUI204722:BR_A0068-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 65771
Gene Ending Position 66088
Gene Strand (Orientation) -
Protein Name type IV secretion system protein VirB2
DNA Sequence 
>gi|56968493:65771-66088 Brucella suis 1330 chromosome II, complete genome
TTTACCTAAGCAGGTAAGAGGCAATTTCGGCGGCAGCGCCAACCACCAGGGCGCCGCCCAGCACCGGCAC
TACATCCATGAAGCGGGCGTGCCGGAATGCCATCTTGTAACCGGACCAGATGATGGCTATGGTAACGATG
GTGATCGATACGCCGCTTAGCAAGTCCAGCACTTTTTGCATGCTTGTATTTACCTTATCGAGGCCACCGT
TGGCGTGCGCCAGGTTAGGCTCGATTGCAGCGATGGAGACAATGAGGGCCAGCAGTAGGTGAGGTAGAAT
CCGCGACAGCGACTTCTTGCTGGGGGAAGCGGTTTTCA
Protein Sequence 
>gi|23499835|ref|NP_699275.1| type IV secretion system protein VirB2 [Brucella suis 1330] MKTASPSKKSLSRILPHLLLALIVSIAAIEPNLAHANGGLDKVNTSMQKVLDLLSGVSITIVTIAIIWSGYKMAFRHARFMDVVPVLGGALVVGAAAEIASYLLR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The Brucella abortus virB operon, encoding a type IV secretion system (T4SS), is required for intracellular replication and persistent infection in the mouse model. The products of the first two genes of the virB operon, virB1 and virB2, are predicted to be localized at the bacterial surface. Both mutants were shown to be nonpolar, as demonstrated by their ability to express the downstream gene virB5 during stationary phase of growth in vitro. Both VirB1 and VirB2 were essential for intracellular replication in J774 macrophages. The nonpolar virB2 mutant was unable to cause persistent infection in the mouse model, demonstrating the essential role of VirB2 in the function of the T4SS apparatus during infection (Sun et al., 2005).

Polar mutations in the virB1 to virB2 intergenic region or in virB2 reduced the detection of VirB5 to a greater extent than they did that of VirB12. A virB1 mutation also eliminates the transcription of virB12 in B suis (Sun et al., 2005).
References
Sun et al., 2005: Sun YH, Rolán HG, den Hartigh AB, Sondervan D, Tsolis RM. Brucella abortus virB12 is expressed during infection but is not an essential component of the type IV secretion system. Infection and immunity. 2005; 73(9); 6048-6054. [PubMed: 16113325].